Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286716841> ?p ?o ?g. }
- W4286716841 abstract "Biomarker development for clinical checkpoint inhibition is still in its early stages. It is critical to determine the cause of the lack of a long-term response in patients after immune checkpoint blockade (ICB) treatment and to develop composite biomarkers or signatures to improve personalized approaches. Three modules that were significantly correlated with the immunotherapeutic response were identified. Stimulatory pathways of cellular immunity, extracellular matrix formation-related pathways, and ATP metabolism-related pathways were enriched. Two distinct transcriptional subtypes were determined. Tumor microenvironment (TME) characteristics were highly correlated with hot and cold tumors. The ICB score was significantly correlated with clinical characteristics including age, Breslow depth, Clerk level, AJCC stage, and T stage. Meanwhile, a low ICB score is characterized by increased activation of immunity, a higher level of immune infiltration, and immune molecule expression. The ICB score showed a robust ability to predict melanoma prognosis in the discovery, internal validation, and external validation cohorts. In addition, a low ICB score was linked to a higher CR/PR rate in the immunotherapeutic cohort. The ICB score could reflect the pre-existing immune features and the expression pattern of Cold versus Hot tumors in melanoma patients. Thus, it has the potential to serve as a reliable predictor of melanoma prognosis and response to ICB therapy." @default.
- W4286716841 created "2022-07-23" @default.
- W4286716841 creator A5000548162 @default.
- W4286716841 creator A5002673921 @default.
- W4286716841 creator A5046597133 @default.
- W4286716841 creator A5070085914 @default.
- W4286716841 creator A5084694246 @default.
- W4286716841 creator A5085331622 @default.
- W4286716841 date "2022-07-22" @default.
- W4286716841 modified "2023-09-30" @default.
- W4286716841 title "Identification of Crucial Gene Modules Related to the Efficiency of Anti-PD-1/PD-L1 Therapy and Comprehensive Analyses of a Novel Signature Based on These Modules" @default.
- W4286716841 cites W1680818974 @default.
- W4286716841 cites W1950829641 @default.
- W4286716841 cites W1966327575 @default.
- W4286716841 cites W1985987855 @default.
- W4286716841 cites W2004630197 @default.
- W4286716841 cites W2009252736 @default.
- W4286716841 cites W2035618305 @default.
- W4286716841 cites W2049553585 @default.
- W4286716841 cites W2060705109 @default.
- W4286716841 cites W2060749303 @default.
- W4286716841 cites W2076948707 @default.
- W4286716841 cites W2100039832 @default.
- W4286716841 cites W2115462905 @default.
- W4286716841 cites W2117692326 @default.
- W4286716841 cites W2123879591 @default.
- W4286716841 cites W2130430382 @default.
- W4286716841 cites W2158497151 @default.
- W4286716841 cites W2159707944 @default.
- W4286716841 cites W2160834915 @default.
- W4286716841 cites W2173456459 @default.
- W4286716841 cites W2179438025 @default.
- W4286716841 cites W2206451428 @default.
- W4286716841 cites W2234115940 @default.
- W4286716841 cites W2302088846 @default.
- W4286716841 cites W2340636398 @default.
- W4286716841 cites W2353075771 @default.
- W4286716841 cites W2507880739 @default.
- W4286716841 cites W2533508881 @default.
- W4286716841 cites W2551911481 @default.
- W4286716841 cites W2559804019 @default.
- W4286716841 cites W2560367415 @default.
- W4286716841 cites W2578528809 @default.
- W4286716841 cites W2593030814 @default.
- W4286716841 cites W2600132724 @default.
- W4286716841 cites W2761575992 @default.
- W4286716841 cites W2785803176 @default.
- W4286716841 cites W2788431960 @default.
- W4286716841 cites W2792656817 @default.
- W4286716841 cites W2796207838 @default.
- W4286716841 cites W2801309958 @default.
- W4286716841 cites W2886498337 @default.
- W4286716841 cites W2897815318 @default.
- W4286716841 cites W2907564726 @default.
- W4286716841 cites W2911909558 @default.
- W4286716841 cites W2947554843 @default.
- W4286716841 cites W2949273159 @default.
- W4286716841 cites W2952001873 @default.
- W4286716841 cites W2961686530 @default.
- W4286716841 cites W2963936065 @default.
- W4286716841 cites W2968872417 @default.
- W4286716841 cites W3000339487 @default.
- W4286716841 cites W3006500278 @default.
- W4286716841 cites W3010538789 @default.
- W4286716841 cites W3012668557 @default.
- W4286716841 cites W3013239365 @default.
- W4286716841 cites W3014183601 @default.
- W4286716841 cites W3026582856 @default.
- W4286716841 cites W3034982015 @default.
- W4286716841 cites W3082221098 @default.
- W4286716841 cites W3088005314 @default.
- W4286716841 cites W3091811425 @default.
- W4286716841 cites W3092902205 @default.
- W4286716841 cites W3100272746 @default.
- W4286716841 cites W3125697683 @default.
- W4286716841 cites W3136653115 @default.
- W4286716841 cites W3174293739 @default.
- W4286716841 cites W3177386775 @default.
- W4286716841 cites W3180291998 @default.
- W4286716841 cites W4224020790 @default.
- W4286716841 cites W4237107236 @default.
- W4286716841 cites W4244068819 @default.
- W4286716841 doi "https://doi.org/10.3389/fgene.2022.893380" @default.
- W4286716841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35937997" @default.
- W4286716841 hasPublicationYear "2022" @default.
- W4286716841 type Work @default.
- W4286716841 citedByCount "0" @default.
- W4286716841 crossrefType "journal-article" @default.
- W4286716841 hasAuthorship W4286716841A5000548162 @default.
- W4286716841 hasAuthorship W4286716841A5002673921 @default.
- W4286716841 hasAuthorship W4286716841A5046597133 @default.
- W4286716841 hasAuthorship W4286716841A5070085914 @default.
- W4286716841 hasAuthorship W4286716841A5084694246 @default.
- W4286716841 hasAuthorship W4286716841A5085331622 @default.
- W4286716841 hasBestOaLocation W42867168411 @default.
- W4286716841 hasConcept C121608353 @default.
- W4286716841 hasConcept C126322002 @default.
- W4286716841 hasConcept C143998085 @default.
- W4286716841 hasConcept C203014093 @default.
- W4286716841 hasConcept C2776107976 @default.