Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286750131> ?p ?o ?g. }
- W4286750131 abstract "Mutations in genes that confer a selective advantage to hematopoietic stem cells (HSCs) drive clonal hematopoiesis (CH). While some CH drivers have been identified, the compendium of all genes able to drive CH upon mutations in HSCs remains incomplete. Exploiting signals of positive selection in blood somatic mutations may be an effective way to identify CH driver genes, analogously to cancer. Using the tumor sample in blood/tumor pairs as reference, we identify blood somatic mutations across more than 12,000 donors from two large cancer genomics cohorts. The application of IntOGen, a driver discovery pipeline, to both cohorts, and more than 24,000 targeted sequenced samples yields a list of close to 70 genes with signals of positive selection in CH, available at http://www.intogen.org/ch . This approach recovers known CH genes, and discovers other candidates." @default.
- W4286750131 created "2022-07-23" @default.
- W4286750131 creator A5009918192 @default.
- W4286750131 creator A5048576516 @default.
- W4286750131 creator A5057300983 @default.
- W4286750131 creator A5074784061 @default.
- W4286750131 date "2022-07-23" @default.
- W4286750131 modified "2023-10-15" @default.
- W4286750131 title "Discovering the drivers of clonal hematopoiesis" @default.
- W4286750131 cites W122645344 @default.
- W4286750131 cites W1956871134 @default.
- W4286750131 cites W1973862547 @default.
- W4286750131 cites W1992826811 @default.
- W4286750131 cites W1998367819 @default.
- W4286750131 cites W2008255210 @default.
- W4286750131 cites W2009720434 @default.
- W4286750131 cites W2041175983 @default.
- W4286750131 cites W2076031927 @default.
- W4286750131 cites W2096460732 @default.
- W4286750131 cites W2119180969 @default.
- W4286750131 cites W2122732537 @default.
- W4286750131 cites W2126816979 @default.
- W4286750131 cites W2127640118 @default.
- W4286750131 cites W2129973040 @default.
- W4286750131 cites W2140952049 @default.
- W4286750131 cites W2149082178 @default.
- W4286750131 cites W2149441684 @default.
- W4286750131 cites W2149858388 @default.
- W4286750131 cites W2158485828 @default.
- W4286750131 cites W2173818354 @default.
- W4286750131 cites W223909586 @default.
- W4286750131 cites W2259938310 @default.
- W4286750131 cites W2344185956 @default.
- W4286750131 cites W2436745791 @default.
- W4286750131 cites W2511116391 @default.
- W4286750131 cites W2521492299 @default.
- W4286750131 cites W2603764892 @default.
- W4286750131 cites W2606675097 @default.
- W4286750131 cites W2611387862 @default.
- W4286750131 cites W2612571615 @default.
- W4286750131 cites W2745259295 @default.
- W4286750131 cites W2759206428 @default.
- W4286750131 cites W2767399544 @default.
- W4286750131 cites W2767749844 @default.
- W4286750131 cites W2770026599 @default.
- W4286750131 cites W2786718111 @default.
- W4286750131 cites W2786854070 @default.
- W4286750131 cites W2787334626 @default.
- W4286750131 cites W2794804602 @default.
- W4286750131 cites W2796408191 @default.
- W4286750131 cites W2801527818 @default.
- W4286750131 cites W2805661432 @default.
- W4286750131 cites W2867868648 @default.
- W4286750131 cites W2894573839 @default.
- W4286750131 cites W2899272142 @default.
- W4286750131 cites W2901512842 @default.
- W4286750131 cites W2902846198 @default.
- W4286750131 cites W2911635110 @default.
- W4286750131 cites W2924903871 @default.
- W4286750131 cites W2950063978 @default.
- W4286750131 cites W2950493549 @default.
- W4286750131 cites W2952094639 @default.
- W4286750131 cites W2963903719 @default.
- W4286750131 cites W2967463001 @default.
- W4286750131 cites W2981548686 @default.
- W4286750131 cites W2982291252 @default.
- W4286750131 cites W2983330893 @default.
- W4286750131 cites W2990857223 @default.
- W4286750131 cites W2990871782 @default.
- W4286750131 cites W2995529700 @default.
- W4286750131 cites W2996805586 @default.
- W4286750131 cites W3004392981 @default.
- W4286750131 cites W3004480399 @default.
- W4286750131 cites W3004570628 @default.
- W4286750131 cites W3004859565 @default.
- W4286750131 cites W3006500278 @default.
- W4286750131 cites W3013784317 @default.
- W4286750131 cites W3029661147 @default.
- W4286750131 cites W3031743685 @default.
- W4286750131 cites W3035594055 @default.
- W4286750131 cites W3046539120 @default.
- W4286750131 cites W3046552632 @default.
- W4286750131 cites W3046666531 @default.
- W4286750131 cites W3046950215 @default.
- W4286750131 cites W3047825284 @default.
- W4286750131 cites W3087350907 @default.
- W4286750131 cites W3093370683 @default.
- W4286750131 cites W3093490071 @default.
- W4286750131 cites W3119440663 @default.
- W4286750131 cites W3184087999 @default.
- W4286750131 cites W3191375198 @default.
- W4286750131 cites W4242239767 @default.
- W4286750131 doi "https://doi.org/10.1038/s41467-022-31878-0" @default.
- W4286750131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35871184" @default.
- W4286750131 hasPublicationYear "2022" @default.
- W4286750131 type Work @default.
- W4286750131 citedByCount "22" @default.
- W4286750131 countsByYear W42867501312022 @default.
- W4286750131 countsByYear W42867501312023 @default.
- W4286750131 crossrefType "journal-article" @default.