FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286751277> ?p ?o ?g. }

• W4286751277 endingPage "47" @default.
• W4286751277 startingPage "38" @default.
• W4286751277 abstract "Little is known about the difference of myocardial gene transcription in young and adult cats and how transcription is further modified in cats with hypertrophic cardiomyopathy (HCM) and with left atrial (LA) thrombus formation. We hypothesized that selected factors for coagulation, endothelial activation, inflammation, and remodelling are modified with age and are activated in the hearts of cats with HCM. Left atrial and ventricular (LV) samples from 12 cats with HCM (seven without (HCMwoAT] and five with LA thrombi [HCMwAT]), and six young (YC) and six adult (AC) control cats without cardiac disease were investigated for relative expression of the following genes using quantitative polymerase chain reaction: von Willebrand factor, a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13, platelet activating factor, E- and P-selectin, intercellular and vascular adhesion molecules-1, ß2-integrin, vascular endothelial growth factor, interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), heat shock protein-70, and myocyte-specific enhancer factor 2C. Significant differences in gene activation were found between YC and AC, and YC and cats with HCM. Compared to AC, MCP-1 and IL-6 were significantly higher in cats with HCM. The presence of an LA thrombus was associated with higher IL-6 expression. These results illustrate the relevance of age and/or lifestyle on gene expression in the feline heart. The gene transcription pattern found in AC hearts might predispose cats to their characteristic cardiac remodelling processes and thrombus formation if disease occurs. It further supports the involvement of inflammation, but not coagulation and endothelial activation, in HCM." @default.
• W4286751277 created "2022-07-23" @default.
• W4286751277 creator A5001265052 @default.
• W4286751277 creator A5007911068 @default.
• W4286751277 creator A5012915569 @default.
• W4286751277 creator A5015797872 @default.
• W4286751277 creator A5040153609 @default.
• W4286751277 creator A5046854343 @default.
• W4286751277 creator A5056905897 @default.
• W4286751277 date "2022-12-01" @default.
• W4286751277 modified "2023-09-26" @default.
• W4286751277 title "Cardiac gene activation varies between young and adult cats and in the presence of hypertrophic cardiomyopathy" @default.
• W4286751277 cites W1580154739 @default.
• W4286751277 cites W1777934328 @default.
• W4286751277 cites W1973268693 @default.
• W4286751277 cites W1978221784 @default.
• W4286751277 cites W1979321667 @default.
• W4286751277 cites W2002127213 @default.
• W4286751277 cites W2016692907 @default.
• W4286751277 cites W2020377054 @default.
• W4286751277 cites W2020803445 @default.
• W4286751277 cites W2027787704 @default.
• W4286751277 cites W2046208657 @default.
• W4286751277 cites W2047587237 @default.
• W4286751277 cites W2055617920 @default.
• W4286751277 cites W2067255121 @default.
• W4286751277 cites W2070419185 @default.
• W4286751277 cites W2071710704 @default.
• W4286751277 cites W2073383011 @default.
• W4286751277 cites W2087783787 @default.
• W4286751277 cites W2093330684 @default.
• W4286751277 cites W2094019580 @default.
• W4286751277 cites W2104179458 @default.
• W4286751277 cites W2117543737 @default.
• W4286751277 cites W2125582128 @default.
• W4286751277 cites W2131257423 @default.
• W4286751277 cites W2134992907 @default.
• W4286751277 cites W2162297869 @default.
• W4286751277 cites W2251226408 @default.
• W4286751277 cites W2334641720 @default.
• W4286751277 cites W2340761255 @default.
• W4286751277 cites W2496800291 @default.
• W4286751277 cites W2522665294 @default.
• W4286751277 cites W2738019036 @default.
• W4286751277 cites W2774870330 @default.
• W4286751277 cites W2799694745 @default.
• W4286751277 cites W2805098025 @default.
• W4286751277 cites W2807995500 @default.
• W4286751277 cites W2922540015 @default.
• W4286751277 cites W2989861270 @default.
• W4286751277 cites W3015790912 @default.
• W4286751277 cites W3045067389 @default.
• W4286751277 cites W3140285727 @default.
• W4286751277 cites W3158722251 @default.
• W4286751277 cites W4200118312 @default.
• W4286751277 cites W4241234432 @default.
• W4286751277 doi "https://doi.org/10.1016/j.rvsc.2022.07.007" @default.
• W4286751277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35917592" @default.
• W4286751277 hasPublicationYear "2022" @default.
• W4286751277 type Work @default.
• W4286751277 citedByCount "2" @default.
• W4286751277 countsByYear W42867512772023 @default.
• W4286751277 crossrefType "journal-article" @default.
• W4286751277 hasAuthorship W4286751277A5001265052 @default.
• W4286751277 hasAuthorship W4286751277A5007911068 @default.
• W4286751277 hasAuthorship W4286751277A5012915569 @default.
• W4286751277 hasAuthorship W4286751277A5015797872 @default.
• W4286751277 hasAuthorship W4286751277A5040153609 @default.
• W4286751277 hasAuthorship W4286751277A5046854343 @default.
• W4286751277 hasAuthorship W4286751277A5056905897 @default.
• W4286751277 hasConcept C126322002 @default.
• W4286751277 hasConcept C134018914 @default.
• W4286751277 hasConcept C203014093 @default.
• W4286751277 hasConcept C2776914184 @default.
• W4286751277 hasConcept C2779394231 @default.
• W4286751277 hasConcept C2779904517 @default.
• W4286751277 hasConcept C2780185194 @default.
• W4286751277 hasConcept C2781362458 @default.
• W4286751277 hasConcept C3018697912 @default.
• W4286751277 hasConcept C71924100 @default.
• W4286751277 hasConcept C86803240 @default.
• W4286751277 hasConcept C89560881 @default.
• W4286751277 hasConceptScore W4286751277C126322002 @default.
• W4286751277 hasConceptScore W4286751277C134018914 @default.
• W4286751277 hasConceptScore W4286751277C203014093 @default.
• W4286751277 hasConceptScore W4286751277C2776914184 @default.
• W4286751277 hasConceptScore W4286751277C2779394231 @default.
• W4286751277 hasConceptScore W4286751277C2779904517 @default.
• W4286751277 hasConceptScore W4286751277C2780185194 @default.
• W4286751277 hasConceptScore W4286751277C2781362458 @default.
• W4286751277 hasConceptScore W4286751277C3018697912 @default.
• W4286751277 hasConceptScore W4286751277C71924100 @default.
• W4286751277 hasConceptScore W4286751277C86803240 @default.
• W4286751277 hasConceptScore W4286751277C89560881 @default.
• W4286751277 hasFunder F4320310921 @default.
• W4286751277 hasFunder F4320334593 @default.
• W4286751277 hasFunder F4320337859 @default.
• W4286751277 hasLocation W42867512771 @default.

• next