FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286836746> ?p ?o ?g. }

• W4286836746 endingPage "2330" @default.
• W4286836746 startingPage "2317" @default.
• W4286836746 abstract "TNM staging of gastric cancer (GC) is useful in predicting prognosis, but its definition is only possible after surgery. It is therefore desirable to develop a method that can predict prognosis and assist management options before surgery.This study investigated 110 GC patients after radical gastrectomy and followed-up for 136 months. Patients' complete clinicopathological data were collected and gastroscopically biopsied or surgically resected tissues were examined for the expression of Her-2, nm-23, CEA and phosphorylated Stat3 (p-Stat3) using immunohistochemistry (IHC). Univariate and multivariate ROC curves, Kaplan-Meier survival curves, and SPSS Version 22.0 and R (version 3.6.1) statistical software were used to analyze the data.Three major findings were observed: (1) Tissue levels of p-Stat3, Her-2, CEA and nm-23 were correlated with GC patients' survival probability termed as survival prediction power (SPP). (2) Using 5-year survival as an end-point, the SPP of the p-Stat3+Her-2 combination was stronger (AUC=0.867) than that of TNM staging (AUC=0.755). (3) Using cut-off values derived from ROC curves, Kaplan-Meier analyses showed that the p-Stat3+Her-2 molecular combination could clearly predict overall survival rates between the predictive low-risk patients (69.2%) and the predictive high-risk patients (13.2%) with a discriminative difference as high as 56.0%.We conclude that area under the ROC curve (AUC) can be used to quantify SPP powers for biomarkers, making cross-comparisons possible among different survival predictors. This study has first established a multi-factor survival prediction model by which the p-Stat3+Her-2 combination has the best discriminative capability to differentiate low-risk patients from high-risk patients in terms of survival prognosis." @default.
• W4286836746 created "2022-07-24" @default.
• W4286836746 creator A5001317969 @default.
• W4286836746 creator A5018305128 @default.
• W4286836746 creator A5026568016 @default.
• W4286836746 creator A5027872311 @default.
• W4286836746 creator A5031106081 @default.
• W4286836746 creator A5045614365 @default.
• W4286836746 creator A5057695677 @default.
• W4286836746 creator A5090645567 @default.
• W4286836746 date "2022-01-01" @default.
• W4286836746 modified "2023-10-14" @default.
• W4286836746 title "Active Stat3 and Her-2 as combined survival predictors show superiority to TNM staging system for postoperative patients with gastric cancer." @default.
• W4286836746 cites W10165358 @default.
• W4286836746 cites W1538131039 @default.
• W4286836746 cites W167646857 @default.
• W4286836746 cites W1894977339 @default.
• W4286836746 cites W1964843748 @default.
• W4286836746 cites W2011954587 @default.
• W4286836746 cites W2020375038 @default.
• W4286836746 cites W2021555948 @default.
• W4286836746 cites W2026360250 @default.
• W4286836746 cites W2032841524 @default.
• W4286836746 cites W2053354145 @default.
• W4286836746 cites W2063143301 @default.
• W4286836746 cites W2065492491 @default.
• W4286836746 cites W2069742146 @default.
• W4286836746 cites W2080277228 @default.
• W4286836746 cites W2090182742 @default.
• W4286836746 cites W2098640128 @default.
• W4286836746 cites W2098672118 @default.
• W4286836746 cites W2116287411 @default.
• W4286836746 cites W2130193783 @default.
• W4286836746 cites W2153988832 @default.
• W4286836746 cites W2159730182 @default.
• W4286836746 cites W2164914782 @default.
• W4286836746 cites W2189046511 @default.
• W4286836746 cites W2272984102 @default.
• W4286836746 cites W2276779069 @default.
• W4286836746 cites W2412117414 @default.
• W4286836746 cites W2437897888 @default.
• W4286836746 cites W2787553551 @default.
• W4286836746 cites W2895926103 @default.
• W4286836746 cites W2981465704 @default.
• W4286836746 cites W2990315986 @default.
• W4286836746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35559376" @default.
• W4286836746 hasPublicationYear "2022" @default.
• W4286836746 type Work @default.
• W4286836746 citedByCount "0" @default.
• W4286836746 crossrefType "journal-article" @default.
• W4286836746 hasAuthorship W4286836746A5001317969 @default.
• W4286836746 hasAuthorship W4286836746A5018305128 @default.
• W4286836746 hasAuthorship W4286836746A5026568016 @default.
• W4286836746 hasAuthorship W4286836746A5027872311 @default.
• W4286836746 hasAuthorship W4286836746A5031106081 @default.
• W4286836746 hasAuthorship W4286836746A5045614365 @default.
• W4286836746 hasAuthorship W4286836746A5057695677 @default.
• W4286836746 hasAuthorship W4286836746A5090645567 @default.
• W4286836746 hasConcept C10515644 @default.
• W4286836746 hasConcept C119857082 @default.
• W4286836746 hasConcept C121608353 @default.
• W4286836746 hasConcept C126322002 @default.
• W4286836746 hasConcept C141071460 @default.
• W4286836746 hasConcept C143998085 @default.
• W4286836746 hasConcept C144301174 @default.
• W4286836746 hasConcept C146357865 @default.
• W4286836746 hasConcept C151730666 @default.
• W4286836746 hasConcept C161584116 @default.
• W4286836746 hasConcept C199163554 @default.
• W4286836746 hasConcept C2776808855 @default.
• W4286836746 hasConcept C2780470880 @default.
• W4286836746 hasConcept C2993415550 @default.
• W4286836746 hasConcept C38180746 @default.
• W4286836746 hasConcept C41008148 @default.
• W4286836746 hasConcept C58471807 @default.
• W4286836746 hasConcept C71924100 @default.
• W4286836746 hasConcept C86803240 @default.
• W4286836746 hasConcept C90924648 @default.
• W4286836746 hasConceptScore W4286836746C10515644 @default.
• W4286836746 hasConceptScore W4286836746C119857082 @default.
• W4286836746 hasConceptScore W4286836746C121608353 @default.
• W4286836746 hasConceptScore W4286836746C126322002 @default.
• W4286836746 hasConceptScore W4286836746C141071460 @default.
• W4286836746 hasConceptScore W4286836746C143998085 @default.
• W4286836746 hasConceptScore W4286836746C144301174 @default.
• W4286836746 hasConceptScore W4286836746C146357865 @default.
• W4286836746 hasConceptScore W4286836746C151730666 @default.
• W4286836746 hasConceptScore W4286836746C161584116 @default.
• W4286836746 hasConceptScore W4286836746C199163554 @default.
• W4286836746 hasConceptScore W4286836746C2776808855 @default.
• W4286836746 hasConceptScore W4286836746C2780470880 @default.
• W4286836746 hasConceptScore W4286836746C2993415550 @default.
• W4286836746 hasConceptScore W4286836746C38180746 @default.
• W4286836746 hasConceptScore W4286836746C41008148 @default.
• W4286836746 hasConceptScore W4286836746C58471807 @default.
• W4286836746 hasConceptScore W4286836746C71924100 @default.
• W4286836746 hasConceptScore W4286836746C86803240 @default.
• W4286836746 hasConceptScore W4286836746C90924648 @default.

• next