Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286851992> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4286851992 abstract "The cerebellar external granule layer (EGL) is the site of the largest transit amplification in the developing brain, and an excellent model for studying neuronal proliferation and differentiation. In addition, evolutionary modifications of its proliferative capability have been responsible for the dramatic expansion of cerebellar size in the amniotes, making the cerebellum an excellent model for evo-devo studies of the vertebrate brain. The constituent cells of the EGL, cerebellar granule progenitors, also represent a significant cell of origin for medulloblastoma, the most prevalent paediatric neuronal tumour. Following transit amplification, granule precursors migrate radially into the internal granular layer of the cerebellum where they represent the largest neuronal population in the mature mammalian brain. In chick, the peak of EGL proliferation occurs towards the end of the second week of gestation. In order to target genetic modification to this layer at the peak of proliferation, we have developed a method for genetic manipulation through ex vivo electroporation of cerebellum slices from embryonic Day 14 chick embryos. This method recapitulates several important aspects of in vivo granule neuron development and will be useful in generating a thorough understanding of cerebellar granule cell proliferation and differentiation, and thus of cerebellum development, evolution and disease." @default.
- W4286851992 created "2022-07-25" @default.
- W4286851992 creator A5012803030 @default.
- W4286851992 creator A5014330394 @default.
- W4286851992 creator A5017833617 @default.
- W4286851992 date "2015-12-14" @default.
- W4286851992 modified "2023-09-30" @default.
- W4286851992 title "<em>Ex Vivo</em> Culture of Chick Cerebellar Slices and Spatially Targeted Electroporation of Granule Cell Precursors" @default.
- W4286851992 doi "https://doi.org/10.3791/53421-v" @default.
- W4286851992 hasPublicationYear "2015" @default.
- W4286851992 type Work @default.
- W4286851992 citedByCount "0" @default.
- W4286851992 crossrefType "journal-article" @default.
- W4286851992 hasAuthorship W4286851992A5012803030 @default.
- W4286851992 hasAuthorship W4286851992A5014330394 @default.
- W4286851992 hasAuthorship W4286851992A5017833617 @default.
- W4286851992 hasConcept C104317684 @default.
- W4286851992 hasConcept C151730666 @default.
- W4286851992 hasConcept C169760540 @default.
- W4286851992 hasConcept C186852380 @default.
- W4286851992 hasConcept C201750760 @default.
- W4286851992 hasConcept C207001950 @default.
- W4286851992 hasConcept C26291073 @default.
- W4286851992 hasConcept C2776464000 @default.
- W4286851992 hasConcept C2778888523 @default.
- W4286851992 hasConcept C2779652256 @default.
- W4286851992 hasConcept C2780680797 @default.
- W4286851992 hasConcept C28328180 @default.
- W4286851992 hasConcept C2908647359 @default.
- W4286851992 hasConcept C2992333117 @default.
- W4286851992 hasConcept C4746552 @default.
- W4286851992 hasConcept C49760210 @default.
- W4286851992 hasConcept C529278444 @default.
- W4286851992 hasConcept C54355233 @default.
- W4286851992 hasConcept C71924100 @default.
- W4286851992 hasConcept C86803240 @default.
- W4286851992 hasConcept C95444343 @default.
- W4286851992 hasConcept C99454951 @default.
- W4286851992 hasConceptScore W4286851992C104317684 @default.
- W4286851992 hasConceptScore W4286851992C151730666 @default.
- W4286851992 hasConceptScore W4286851992C169760540 @default.
- W4286851992 hasConceptScore W4286851992C186852380 @default.
- W4286851992 hasConceptScore W4286851992C201750760 @default.
- W4286851992 hasConceptScore W4286851992C207001950 @default.
- W4286851992 hasConceptScore W4286851992C26291073 @default.
- W4286851992 hasConceptScore W4286851992C2776464000 @default.
- W4286851992 hasConceptScore W4286851992C2778888523 @default.
- W4286851992 hasConceptScore W4286851992C2779652256 @default.
- W4286851992 hasConceptScore W4286851992C2780680797 @default.
- W4286851992 hasConceptScore W4286851992C28328180 @default.
- W4286851992 hasConceptScore W4286851992C2908647359 @default.
- W4286851992 hasConceptScore W4286851992C2992333117 @default.
- W4286851992 hasConceptScore W4286851992C4746552 @default.
- W4286851992 hasConceptScore W4286851992C49760210 @default.
- W4286851992 hasConceptScore W4286851992C529278444 @default.
- W4286851992 hasConceptScore W4286851992C54355233 @default.
- W4286851992 hasConceptScore W4286851992C71924100 @default.
- W4286851992 hasConceptScore W4286851992C86803240 @default.
- W4286851992 hasConceptScore W4286851992C95444343 @default.
- W4286851992 hasConceptScore W4286851992C99454951 @default.
- W4286851992 hasIssue "106" @default.
- W4286851992 hasLocation W42868519921 @default.
- W4286851992 hasOpenAccess W4286851992 @default.
- W4286851992 hasPrimaryLocation W42868519921 @default.
- W4286851992 hasRelatedWork W178912716 @default.
- W4286851992 hasRelatedWork W1976217132 @default.
- W4286851992 hasRelatedWork W2002687823 @default.
- W4286851992 hasRelatedWork W2012870647 @default.
- W4286851992 hasRelatedWork W2076376539 @default.
- W4286851992 hasRelatedWork W2148860249 @default.
- W4286851992 hasRelatedWork W2207309163 @default.
- W4286851992 hasRelatedWork W2532259957 @default.
- W4286851992 hasRelatedWork W2790626965 @default.
- W4286851992 hasRelatedWork W4328023284 @default.
- W4286851992 isParatext "false" @default.
- W4286851992 isRetracted "false" @default.
- W4286851992 workType "article" @default.