Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286852019> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4286852019 abstract "Nanoparticle-based delivery vehicles have shown great promise for intracellular targeting applications, providing a mechanism to specifically alter cellular signaling and gene expression. In a previous investigation, the synthesis of ultra-small solid lipid nanoparticles (SLNs) for topical drug delivery and biomarker detection applications was demonstrated. SLNs are a well-studied example of a nanoparticle delivery system that has emerged as a promising drug delivery vehicle. In this study, SLNs were loaded with a fluorescent dye and used as a model to investigate particle-cell interactions. The phase inversion temperature (PIT) method was used for the synthesis of ultra-small populations of biocompatible nanoparticles. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylphenyltetrazolium bromide (MTT) assay was utilized in order to establish appropriate dosing levels prior to the nanoparticle-cell interaction studies. Furthermore, primary human dermal fibroblasts and mouse dendritic cells were exposed to dye-loaded SLN over time and the interactions with respect to toxicity and particle uptake were characterized using fluorescence microscopy and flow cytometry. This study demonstrated that ultra-small SLNs, as a nanoparticle delivery system, are suitable for intracellular targeting of different cell types." @default.
- W4286852019 created "2022-07-25" @default.
- W4286852019 creator A5015132619 @default.
- W4286852019 creator A5016218098 @default.
- W4286852019 creator A5060850895 @default.
- W4286852019 creator A5062666085 @default.
- W4286852019 date "2015-11-17" @default.
- W4286852019 modified "2023-10-01" @default.
- W4286852019 title "Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications" @default.
- W4286852019 doi "https://doi.org/10.3791/53102-v" @default.
- W4286852019 hasPublicationYear "2015" @default.
- W4286852019 type Work @default.
- W4286852019 citedByCount "0" @default.
- W4286852019 crossrefType "journal-article" @default.
- W4286852019 hasAuthorship W4286852019A5015132619 @default.
- W4286852019 hasAuthorship W4286852019A5016218098 @default.
- W4286852019 hasAuthorship W4286852019A5060850895 @default.
- W4286852019 hasAuthorship W4286852019A5062666085 @default.
- W4286852019 hasConcept C121332964 @default.
- W4286852019 hasConcept C12554922 @default.
- W4286852019 hasConcept C153911025 @default.
- W4286852019 hasConcept C155672457 @default.
- W4286852019 hasConcept C169274487 @default.
- W4286852019 hasConcept C171250308 @default.
- W4286852019 hasConcept C185592680 @default.
- W4286852019 hasConcept C192562407 @default.
- W4286852019 hasConcept C199529486 @default.
- W4286852019 hasConcept C2779820397 @default.
- W4286852019 hasConcept C553184892 @default.
- W4286852019 hasConcept C55493867 @default.
- W4286852019 hasConcept C62520636 @default.
- W4286852019 hasConcept C79879829 @default.
- W4286852019 hasConcept C86803240 @default.
- W4286852019 hasConcept C91881484 @default.
- W4286852019 hasConceptScore W4286852019C121332964 @default.
- W4286852019 hasConceptScore W4286852019C12554922 @default.
- W4286852019 hasConceptScore W4286852019C153911025 @default.
- W4286852019 hasConceptScore W4286852019C155672457 @default.
- W4286852019 hasConceptScore W4286852019C169274487 @default.
- W4286852019 hasConceptScore W4286852019C171250308 @default.
- W4286852019 hasConceptScore W4286852019C185592680 @default.
- W4286852019 hasConceptScore W4286852019C192562407 @default.
- W4286852019 hasConceptScore W4286852019C199529486 @default.
- W4286852019 hasConceptScore W4286852019C2779820397 @default.
- W4286852019 hasConceptScore W4286852019C553184892 @default.
- W4286852019 hasConceptScore W4286852019C55493867 @default.
- W4286852019 hasConceptScore W4286852019C62520636 @default.
- W4286852019 hasConceptScore W4286852019C79879829 @default.
- W4286852019 hasConceptScore W4286852019C86803240 @default.
- W4286852019 hasConceptScore W4286852019C91881484 @default.
- W4286852019 hasIssue "105" @default.
- W4286852019 hasLocation W42868520191 @default.
- W4286852019 hasOpenAccess W4286852019 @default.
- W4286852019 hasPrimaryLocation W42868520191 @default.
- W4286852019 hasRelatedWork W1983818829 @default.
- W4286852019 hasRelatedWork W2011155894 @default.
- W4286852019 hasRelatedWork W2020532243 @default.
- W4286852019 hasRelatedWork W2083230873 @default.
- W4286852019 hasRelatedWork W2191999092 @default.
- W4286852019 hasRelatedWork W2316862923 @default.
- W4286852019 hasRelatedWork W2896399282 @default.
- W4286852019 hasRelatedWork W3043599963 @default.
- W4286852019 hasRelatedWork W2168441468 @default.
- W4286852019 hasRelatedWork W2491030969 @default.
- W4286852019 isParatext "false" @default.
- W4286852019 isRetracted "false" @default.
- W4286852019 workType "article" @default.