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- W4287009872 endingPage "8114" @default.
- W4287009872 startingPage "8114" @default.
- W4287009872 abstract "In recent decades, hyaluronic acid (HA) has attracted great attention as a new treatment option for osteoarthritis. Classical therapies are not able to stop the cartilage degeneration process nor do they favor tissue repair. Nowadays, it is accepted that high molecular weight HA can reduce inflammation by promoting tissue regeneration; therefore, the aim of this study was to verify the efficacy of a new high molecular weight HA of plant origin (called GreenIuronic®) in maintaining joint homeostasis and preventing the harmful processes of osteoarthritis.The bioavailability of GreenIuronic® was investigated in a 3D intestinal barrier model that mimics human oral intake while excluding damage to the intestinal barrier. Furthermore, the chemical significance and biological properties of GreenIuronic® were investigated in conditions that simulate osteoarthritis.Our data demonstrated that GreenIuronic® crosses the intestinal barrier without side effects as it has a chemical-biological profile, which could be responsible for many specific chondrocyte functions. Furthermore, in the osteoarthritis model, GreenIuronic® can modulate the molecular mechanism responsible for preventing and restoring the degradation of cartilage.According to our results, this new form of HA appears to be well absorbed and distributed to chondrocytes, preserving their biological activities. Therefore, the oral administration of GreenIuronic® in humans can be considered a valid strategy to obtain beneficial therapeutic effects during osteoarthritis." @default.
- W4287009872 created "2022-07-25" @default.
- W4287009872 creator A5001533521 @default.
- W4287009872 creator A5003881266 @default.
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- W4287009872 creator A5032650785 @default.
- W4287009872 creator A5033030825 @default.
- W4287009872 creator A5046100788 @default.
- W4287009872 date "2022-07-23" @default.
- W4287009872 modified "2023-10-01" @default.
- W4287009872 title "New Hyaluronic Acid from Plant Origin to Improve Joint Protection—An In Vitro Study" @default.
- W4287009872 cites W1149703769 @default.
- W4287009872 cites W1532119852 @default.
- W4287009872 cites W1574019439 @default.
- W4287009872 cites W1797559164 @default.
- W4287009872 cites W1831989259 @default.
- W4287009872 cites W1898224537 @default.
- W4287009872 cites W1935429961 @default.
- W4287009872 cites W1965665343 @default.
- W4287009872 cites W1966282672 @default.
- W4287009872 cites W1970976508 @default.
- W4287009872 cites W1976356872 @default.
- W4287009872 cites W1977167000 @default.
- W4287009872 cites W1984902510 @default.
- W4287009872 cites W2005289866 @default.
- W4287009872 cites W2006315282 @default.
- W4287009872 cites W2011720064 @default.
- W4287009872 cites W2039693707 @default.
- W4287009872 cites W2051536372 @default.
- W4287009872 cites W2052126510 @default.
- W4287009872 cites W2059544487 @default.
- W4287009872 cites W2059979933 @default.
- W4287009872 cites W2067064292 @default.
- W4287009872 cites W2070522638 @default.
- W4287009872 cites W2072029917 @default.
- W4287009872 cites W2074916551 @default.
- W4287009872 cites W2080541282 @default.
- W4287009872 cites W2103907900 @default.
- W4287009872 cites W2114577347 @default.
- W4287009872 cites W2145307927 @default.
- W4287009872 cites W2146093964 @default.
- W4287009872 cites W2215687845 @default.
- W4287009872 cites W2218241030 @default.
- W4287009872 cites W2245432015 @default.
- W4287009872 cites W2317574006 @default.
- W4287009872 cites W2395467752 @default.
- W4287009872 cites W2412996686 @default.
- W4287009872 cites W2519760004 @default.
- W4287009872 cites W2525285693 @default.
- W4287009872 cites W2528411961 @default.
- W4287009872 cites W2554099103 @default.
- W4287009872 cites W2555470647 @default.
- W4287009872 cites W2752714098 @default.
- W4287009872 cites W2756354197 @default.
- W4287009872 cites W2770509237 @default.
- W4287009872 cites W2782442729 @default.
- W4287009872 cites W2792650217 @default.
- W4287009872 cites W2801455382 @default.
- W4287009872 cites W2809231499 @default.
- W4287009872 cites W2892548826 @default.
- W4287009872 cites W2905204949 @default.
- W4287009872 cites W2906812636 @default.
- W4287009872 cites W2907680369 @default.
- W4287009872 cites W2918686397 @default.
- W4287009872 cites W2932974387 @default.
- W4287009872 cites W2946864560 @default.
- W4287009872 cites W2958611749 @default.
- W4287009872 cites W2990036735 @default.
- W4287009872 cites W3000036091 @default.
- W4287009872 cites W3003263728 @default.
- W4287009872 cites W3004403979 @default.
- W4287009872 cites W3007813936 @default.
- W4287009872 cites W3007994563 @default.
- W4287009872 cites W3012876718 @default.
- W4287009872 cites W3013729112 @default.
- W4287009872 cites W3023154622 @default.
- W4287009872 cites W3031433013 @default.
- W4287009872 cites W3043620206 @default.
- W4287009872 cites W3047136482 @default.
- W4287009872 cites W3081140927 @default.
- W4287009872 cites W3092093479 @default.
- W4287009872 cites W3136637824 @default.
- W4287009872 cites W3156408207 @default.
- W4287009872 cites W3168283803 @default.
- W4287009872 cites W3179150874 @default.
- W4287009872 cites W3180883606 @default.
- W4287009872 cites W3188139486 @default.
- W4287009872 cites W3197560723 @default.
- W4287009872 cites W3205306750 @default.
- W4287009872 cites W3211104107 @default.
- W4287009872 cites W3213133224 @default.
- W4287009872 cites W3215623244 @default.
- W4287009872 cites W4210811756 @default.
- W4287009872 cites W4233138142 @default.
- W4287009872 cites W4200107345 @default.
- W4287009872 doi "https://doi.org/10.3390/ijms23158114" @default.