Matches in SemOpenAlex for { <https://semopenalex.org/work/W4287009944> ?p ?o ?g. }
- W4287009944 endingPage "3595" @default.
- W4287009944 startingPage "3595" @default.
- W4287009944 abstract "Metastatic pancreatic cancer has an invariably fatal outcome, with an estimated median progression-free survival of approximately six months employing our best combination chemotherapeutic regimens. Once drug resistance develops, manifested by increased primary tumor size and new and growing metastases, patients often die rapidly from their disease. Emerging evidence indicates that chemotherapy may contribute to the development of drug resistance through the upregulation of epithelial-mesenchymal transition (EMT) pathways and subsequent cancer stem cell (CSC) enrichment. Neuraminidase-1 (Neu-1) regulates the activation of several receptor tyrosine kinases implicated in EMT induction, angiogenesis, and cellular proliferation. Here, continuous therapeutic targeting of Neu-1 using parenteral perfusion of oseltamivir phosphate (OP) and aspirin (ASA) with gemcitabine (GEM) treatment significantly disrupts tumor progression, critical compensatory signaling mechanisms, EMT program, CSC, and metastases in a preclinical mouse model of human pancreatic cancer. ASA- and OP-treated xenotumors significantly inhibited the metastatic potential when transferred into animals." @default.
- W4287009944 created "2022-07-25" @default.
- W4287009944 creator A5026699953 @default.
- W4287009944 creator A5041261735 @default.
- W4287009944 creator A5053078335 @default.
- W4287009944 creator A5086616644 @default.
- W4287009944 date "2022-07-23" @default.
- W4287009944 modified "2023-09-26" @default.
- W4287009944 title "Repositioning of Old Drugs for Novel Cancer Therapies: Continuous Therapeutic Perfusion of Aspirin and Oseltamivir Phosphate with Gemcitabine Treatment Disables Tumor Progression, Chemoresistance, and Metastases" @default.
- W4287009944 cites W1551102474 @default.
- W4287009944 cites W1967320533 @default.
- W4287009944 cites W1970087902 @default.
- W4287009944 cites W1978536616 @default.
- W4287009944 cites W1989569828 @default.
- W4287009944 cites W1993430254 @default.
- W4287009944 cites W1999132074 @default.
- W4287009944 cites W2007019182 @default.
- W4287009944 cites W2014691022 @default.
- W4287009944 cites W2021880716 @default.
- W4287009944 cites W2026240866 @default.
- W4287009944 cites W2035880310 @default.
- W4287009944 cites W2039210293 @default.
- W4287009944 cites W2039213842 @default.
- W4287009944 cites W2040634521 @default.
- W4287009944 cites W2042380860 @default.
- W4287009944 cites W2043919610 @default.
- W4287009944 cites W2051011074 @default.
- W4287009944 cites W2054735424 @default.
- W4287009944 cites W2066254965 @default.
- W4287009944 cites W2081410358 @default.
- W4287009944 cites W2083172582 @default.
- W4287009944 cites W2086834859 @default.
- W4287009944 cites W2089818916 @default.
- W4287009944 cites W2095483969 @default.
- W4287009944 cites W2118256381 @default.
- W4287009944 cites W2137715553 @default.
- W4287009944 cites W2138240181 @default.
- W4287009944 cites W2139151018 @default.
- W4287009944 cites W2140551998 @default.
- W4287009944 cites W2145254159 @default.
- W4287009944 cites W2151253787 @default.
- W4287009944 cites W2158600471 @default.
- W4287009944 cites W2165480504 @default.
- W4287009944 cites W2168645747 @default.
- W4287009944 cites W2169895148 @default.
- W4287009944 cites W2258531487 @default.
- W4287009944 cites W2337230445 @default.
- W4287009944 cites W2512558866 @default.
- W4287009944 cites W2531275489 @default.
- W4287009944 cites W2560396365 @default.
- W4287009944 cites W2571166948 @default.
- W4287009944 cites W2574854368 @default.
- W4287009944 cites W2576896693 @default.
- W4287009944 cites W2587264845 @default.
- W4287009944 cites W2601982013 @default.
- W4287009944 cites W2606553662 @default.
- W4287009944 cites W2623685580 @default.
- W4287009944 cites W2754912449 @default.
- W4287009944 cites W2766224815 @default.
- W4287009944 cites W2921863883 @default.
- W4287009944 cites W2944503022 @default.
- W4287009944 cites W2953344451 @default.
- W4287009944 cites W2955844551 @default.
- W4287009944 cites W2972292993 @default.
- W4287009944 cites W3047119758 @default.
- W4287009944 cites W3089313321 @default.
- W4287009944 cites W3092098441 @default.
- W4287009944 cites W3106879533 @default.
- W4287009944 cites W3106961467 @default.
- W4287009944 cites W3137803078 @default.
- W4287009944 cites W3150537508 @default.
- W4287009944 cites W3154378828 @default.
- W4287009944 cites W3161782839 @default.
- W4287009944 cites W3170100266 @default.
- W4287009944 cites W3194200616 @default.
- W4287009944 cites W3211117713 @default.
- W4287009944 cites W4200307603 @default.
- W4287009944 cites W4211122150 @default.
- W4287009944 cites W4221077568 @default.
- W4287009944 doi "https://doi.org/10.3390/cancers14153595" @default.
- W4287009944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35892853" @default.
- W4287009944 hasPublicationYear "2022" @default.
- W4287009944 type Work @default.
- W4287009944 citedByCount "1" @default.
- W4287009944 countsByYear W42870099442023 @default.
- W4287009944 crossrefType "journal-article" @default.
- W4287009944 hasAuthorship W4287009944A5026699953 @default.
- W4287009944 hasAuthorship W4287009944A5041261735 @default.
- W4287009944 hasAuthorship W4287009944A5053078335 @default.
- W4287009944 hasAuthorship W4287009944A5086616644 @default.
- W4287009944 hasBestOaLocation W42870099441 @default.
- W4287009944 hasConcept C121608353 @default.
- W4287009944 hasConcept C126322002 @default.
- W4287009944 hasConcept C143998085 @default.
- W4287009944 hasConcept C2779013556 @default.
- W4287009944 hasConcept C2779256057 @default.
- W4287009944 hasConcept C2780210213 @default.
- W4287009944 hasConcept C2780258809 @default.