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- W4287025246 abstract "Spiral waves of excitation in cardiac tissue are associated with life-threatening cardiac arrhythmias. It is, therefore, important to study the electrophysiological factors that affect the dynamics of these spiral waves. By using an electrophysiologically detailed mathematical model of a myocyte (cardiac cell), we study the effects of cellular parameters, such as membrane-ion-channel conductances, on the properties of the action-potential (AP) of a myocyte. We then investigate how changes in these properties, specifically the upstroke velocity and the AP duration (APD), affect the frequency $omega$ of a spiral wave in the mathematical model that we use for human-ventricular tissue. We find that an increase (decrease) in this upstroke-velocity or a decrease (increase) in the AP duration increases (decreases) $omega$. We also study how other intercellular factors, such as the fibroblast-myocyte coupling, diffusive coupling strength, and the effective number of neighboring myocytes, modulate $omega$. Finally, we demonstrate how a spiral wave can drift to a region with a high density of fibroblasts. Our results provide a natural explanation for the anchoring of spiral waves in highly fibrotic regions in fibrotic hearts." @default.
- W4287025246 created "2022-07-25" @default.
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- W4287025246 date "2021-08-14" @default.
- W4287025246 modified "2023-10-16" @default.
- W4287025246 title "An in silico study of electrophysiological parameters that affect the spiral-wave frequency in mathematical models for cardiac tissue" @default.
- W4287025246 doi "https://doi.org/10.48550/arxiv.2108.06531" @default.
- W4287025246 hasPublicationYear "2021" @default.
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