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- W4287077812 abstract "Biochemical circadian rhythm oscillations play an important role in many signalling mechanisms. In this work, we explore some of the biophysical mechanisms responsible for sustaining robust oscillations by constructing a minimal but analytically tractable model of the circadian oscillations in the KaiABC protein system found in the cyanobacteria $S. elongatus$. In particular, our minimal model explicitly accounts for two experimentally characterized biophysical features of the KaiABC protein system, namely, a differential binding affinity and an ultrasensitive response. Our analytical work shows how these mechanisms might be crucial for promoting robust oscillations even in sub optimal nutrient conditions. Our analytical and numerical work also identifies mechanisms by which biological clocks can stably maintain a constant time period under a variety of nutrient conditions. Finally, our work also explores the thermodynamic costs associated with the generation of robust sustained oscillations and shows that the net rate of entropy production alone might not be a good figure of merit to asses the quality of oscillations." @default.
- W4287077812 created "2022-07-25" @default.
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- W4287077812 date "2021-07-14" @default.
- W4287077812 modified "2023-09-27" @default.
- W4287077812 title "A mechanism for the generation of robust circadian oscillations through ultransensitivity and differential binding affinity" @default.
- W4287077812 doi "https://doi.org/10.48550/arxiv.2107.06954" @default.
- W4287077812 hasPublicationYear "2021" @default.
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