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- W4287146768 abstract "Low efficiency has seriously restricted the application of prime editing (PE) systems in plants. In this study, we develop an enhanced plant prime editor 2 system, enpPE2, by stacking various optimization strategies, including updating the PE architecture to PEmax and expressing engineered pegRNA with a structured motif under the control of a composite promoter. In T0 rice plants, enpPE2 exhibits editing frequencies of 64.58% to 77.08%, which are much higher than the frequencies with unmodified pPE2. Our results indicate that the enpPE2 system provides a robust and powerful tool for the precise modification of plant genomes." @default.
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- W4287146768 date "2022-07-25" @default.
- W4287146768 modified "2023-10-17" @default.
- W4287146768 title "Development of a highly efficient prime editor 2 system in plants" @default.
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- W4287146768 doi "https://doi.org/10.1186/s13059-022-02730-x" @default.
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