Matches in SemOpenAlex for { <https://semopenalex.org/work/W4287187510> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4287187510 abstract "To investigate the role of circular RNA MYLK (circMYLK) in colorectal cancer (CRC).Patients with CRC were enrolled and cancerous tissues were collected. CircMYLK expression was measured by quantitative real-time polymerase chain reaction (qRT-PCR). The diagnostic value of circMYLK was determined by ROC curve. In vitro knockdown of circMYLK was carried out to investigate the proliferation, migration and invasion capabilities of CRC cell lines.We first found that circMYLK expression was markedly enhanced in human CRC tissues, serum and cell lines, which was correlated with poor prognosis and some detrimental clinical characteristics. ROC curve showed that circMYLK could be a diagnostic biomarker of CRC. The proliferation ability of CRC cells was markedly inhibited, while higher apoptosis rate was induced after circMYLK deplition. In addition, the migration and invasion abilities of CRC cells were suppressed following circMYLK silencing.Our results implicate that circMYLK functions as oncogenic stimuli in CRC and may be a novel diagnostic and therapeutic targets of CRC." @default.
- W4287187510 created "2022-07-25" @default.
- W4287187510 creator A5020562917 @default.
- W4287187510 creator A5029721738 @default.
- W4287187510 date "2021-05-01" @default.
- W4287187510 modified "2023-09-29" @default.
- W4287187510 title "CircMYLK Promotes Cell Proliferation, Migration, and Invasion in Colorectal Cancer." @default.
- W4287187510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34162563" @default.
- W4287187510 hasPublicationYear "2021" @default.
- W4287187510 type Work @default.
- W4287187510 citedByCount "1" @default.
- W4287187510 countsByYear W42871875102022 @default.
- W4287187510 crossrefType "journal-article" @default.
- W4287187510 hasAuthorship W4287187510A5020562917 @default.
- W4287187510 hasAuthorship W4287187510A5029721738 @default.
- W4287187510 hasConcept C104317684 @default.
- W4287187510 hasConcept C119056186 @default.
- W4287187510 hasConcept C121608353 @default.
- W4287187510 hasConcept C126322002 @default.
- W4287187510 hasConcept C1491633281 @default.
- W4287187510 hasConcept C173396325 @default.
- W4287187510 hasConcept C190283241 @default.
- W4287187510 hasConcept C2781197716 @default.
- W4287187510 hasConcept C48023723 @default.
- W4287187510 hasConcept C502942594 @default.
- W4287187510 hasConcept C526805850 @default.
- W4287187510 hasConcept C54355233 @default.
- W4287187510 hasConcept C62112901 @default.
- W4287187510 hasConcept C71924100 @default.
- W4287187510 hasConcept C81885089 @default.
- W4287187510 hasConcept C86803240 @default.
- W4287187510 hasConceptScore W4287187510C104317684 @default.
- W4287187510 hasConceptScore W4287187510C119056186 @default.
- W4287187510 hasConceptScore W4287187510C121608353 @default.
- W4287187510 hasConceptScore W4287187510C126322002 @default.
- W4287187510 hasConceptScore W4287187510C1491633281 @default.
- W4287187510 hasConceptScore W4287187510C173396325 @default.
- W4287187510 hasConceptScore W4287187510C190283241 @default.
- W4287187510 hasConceptScore W4287187510C2781197716 @default.
- W4287187510 hasConceptScore W4287187510C48023723 @default.
- W4287187510 hasConceptScore W4287187510C502942594 @default.
- W4287187510 hasConceptScore W4287187510C526805850 @default.
- W4287187510 hasConceptScore W4287187510C54355233 @default.
- W4287187510 hasConceptScore W4287187510C62112901 @default.
- W4287187510 hasConceptScore W4287187510C71924100 @default.
- W4287187510 hasConceptScore W4287187510C81885089 @default.
- W4287187510 hasConceptScore W4287187510C86803240 @default.
- W4287187510 hasLocation W42871875101 @default.
- W4287187510 hasOpenAccess W4287187510 @default.
- W4287187510 hasPrimaryLocation W42871875101 @default.
- W4287187510 hasRelatedWork W11877123 @default.
- W4287187510 hasRelatedWork W12539984 @default.
- W4287187510 hasRelatedWork W12585302 @default.
- W4287187510 hasRelatedWork W1994912 @default.
- W4287187510 hasRelatedWork W3422088 @default.
- W4287187510 hasRelatedWork W4952422 @default.
- W4287187510 hasRelatedWork W6346941 @default.
- W4287187510 hasRelatedWork W7190444 @default.
- W4287187510 hasRelatedWork W8099725 @default.
- W4287187510 hasRelatedWork W9873545 @default.
- W4287187510 isParatext "false" @default.
- W4287187510 isRetracted "false" @default.
- W4287187510 workType "article" @default.