Matches in SemOpenAlex for { <https://semopenalex.org/work/W4287307730> ?p ?o ?g. }
- W4287307730 endingPage "2113" @default.
- W4287307730 startingPage "2095" @default.
- W4287307730 abstract "Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently prescribed drug classes with wide therapeutic applications over the centuries. Starting from the use of salicylate-containing willow leaves to the recent rise and fall of highly selective cyclooxygenase-2 (COX-2) inhibitors and the latest dual-acting anti-inflammatory molecules, they have displayed a rapid and ongoing evolution. Despite the enormous advances in the last twenty years, investigators are still in search of the design and development of more potent and safer therapy against inflammatory conditions. This challenge has been increasingly attractive as the emergence of inflammation as a common seed and unifying mechanism for most chronic diseases. Indeed, this fact put the NSAIDs in the spotlight for repurposing against inflammation-related disorders. This review attempts to present a historical perspective on the evolution of NSAIDs, regarding their COX-dependent/independent mode of actions, structural and mechanism-based classifications, and adverse effects. Additionally, a systematic review of previous studies was carried out to show the current situation in drug repurposing, particularly in cancers associated with the GI tract such as gastric and colorectal carcinoma. In the case of non-GI-related cancers, preclinical studies elucidating the effects and modes of action were collected and summarized." @default.
- W4287307730 created "2022-07-25" @default.
- W4287307730 creator A5029949964 @default.
- W4287307730 creator A5036123775 @default.
- W4287307730 creator A5039986210 @default.
- W4287307730 creator A5050112324 @default.
- W4287307730 creator A5084098164 @default.
- W4287307730 creator A5089903560 @default.
- W4287307730 date "2022-07-25" @default.
- W4287307730 modified "2023-10-06" @default.
- W4287307730 title "Looking at NSAIDs from a historical perspective and their current status in drug repurposing for cancer treatment and prevention" @default.
- W4287307730 cites W129031804 @default.
- W4287307730 cites W1480874656 @default.
- W4287307730 cites W1485442945 @default.
- W4287307730 cites W1534796888 @default.
- W4287307730 cites W1558367558 @default.
- W4287307730 cites W1582834232 @default.
- W4287307730 cites W1740416844 @default.
- W4287307730 cites W1966183396 @default.
- W4287307730 cites W1968246103 @default.
- W4287307730 cites W1974235572 @default.
- W4287307730 cites W1976654542 @default.
- W4287307730 cites W1980014160 @default.
- W4287307730 cites W1982512584 @default.
- W4287307730 cites W1984233793 @default.
- W4287307730 cites W1984368960 @default.
- W4287307730 cites W1986936335 @default.
- W4287307730 cites W1988564036 @default.
- W4287307730 cites W1995425192 @default.
- W4287307730 cites W1998238028 @default.
- W4287307730 cites W2002569735 @default.
- W4287307730 cites W2006551872 @default.
- W4287307730 cites W2008574207 @default.
- W4287307730 cites W2009944894 @default.
- W4287307730 cites W2021512036 @default.
- W4287307730 cites W2024835957 @default.
- W4287307730 cites W2027915229 @default.
- W4287307730 cites W2028052683 @default.
- W4287307730 cites W2037107042 @default.
- W4287307730 cites W2046293893 @default.
- W4287307730 cites W2050945556 @default.
- W4287307730 cites W2062267481 @default.
- W4287307730 cites W2062774943 @default.
- W4287307730 cites W2065188145 @default.
- W4287307730 cites W2065861460 @default.
- W4287307730 cites W2074203890 @default.
- W4287307730 cites W2080504447 @default.
- W4287307730 cites W2082906650 @default.
- W4287307730 cites W2087102885 @default.
- W4287307730 cites W2094584843 @default.
- W4287307730 cites W2104634899 @default.
- W4287307730 cites W2108777528 @default.
- W4287307730 cites W2115899272 @default.
- W4287307730 cites W2118910625 @default.
- W4287307730 cites W2121482161 @default.
- W4287307730 cites W2125376440 @default.
- W4287307730 cites W2129935236 @default.
- W4287307730 cites W2132988098 @default.
- W4287307730 cites W2140044845 @default.
- W4287307730 cites W2146478455 @default.
- W4287307730 cites W2157304020 @default.
- W4287307730 cites W2162392926 @default.
- W4287307730 cites W2162663926 @default.
- W4287307730 cites W2197093416 @default.
- W4287307730 cites W2509391596 @default.
- W4287307730 cites W2572596693 @default.
- W4287307730 cites W2772755903 @default.
- W4287307730 cites W2780816526 @default.
- W4287307730 cites W2790982868 @default.
- W4287307730 cites W2802764230 @default.
- W4287307730 cites W2803746414 @default.
- W4287307730 cites W2807749647 @default.
- W4287307730 cites W2883867769 @default.
- W4287307730 cites W2888246635 @default.
- W4287307730 cites W2888644660 @default.
- W4287307730 cites W2890017731 @default.
- W4287307730 cites W2899349918 @default.
- W4287307730 cites W2912067439 @default.
- W4287307730 cites W2943111330 @default.
- W4287307730 cites W2945874291 @default.
- W4287307730 cites W2956263305 @default.
- W4287307730 cites W2967586142 @default.
- W4287307730 cites W2968671948 @default.
- W4287307730 cites W2971991049 @default.
- W4287307730 cites W2972655306 @default.
- W4287307730 cites W2978493661 @default.
- W4287307730 cites W2981758101 @default.
- W4287307730 cites W2989091742 @default.
- W4287307730 cites W2997993130 @default.
- W4287307730 cites W3000488011 @default.
- W4287307730 cites W3009507530 @default.
- W4287307730 cites W3013498471 @default.
- W4287307730 cites W3016280519 @default.
- W4287307730 cites W3019074378 @default.
- W4287307730 cites W3023762347 @default.
- W4287307730 cites W3027764773 @default.
- W4287307730 cites W3033374128 @default.
- W4287307730 cites W3034333201 @default.