Matches in SemOpenAlex for { <https://semopenalex.org/work/W4287377532> ?p ?o ?g. }
- W4287377532 abstract "Abstract In biology, evolutionary conserved protein sequences show homologous physiological phenotypes in their structures and functions. If the protein has a vital function, its sequence is usually conserved across the species. However, in highly conserved protein there still remains small differences across the species. Upon protein–protein interaction (PPI), it is observed that the conserved proteins can have different binding partners that are considered to be caused by the small sequence variations in a specific domain. Thyroglobulin (TG) is the most commonly found protein in the thyroid gland of vertebrates and serves as the precursor of the thyroid hormones, tetraiodothyronine and triiodothyronine that are critical for growth, development and metabolism in vertebrates. In this study, we comparatively analyzed the sequences and structures of the highly conserved regions of TG from two different species in relation to their PPIs. In order to do so, we employed SIM for sequence alignment, STRING for PPI analysis and cryo-electron microscopy for 3D structural analysis. Our Cryo-EM model for TG of Bos taurus determined at 7.1 Å resolution fitted well with the previously published Cryo-EM model for Homo sapiens TG. By demonstrating overall structural homology between TGs from different species, we address that local amino acid sequence variation is sufficient to alter PPIs specific for the organism. We predict that our result will contribute to a deeper understanding in the evolutionary pattern applicable to many other proteins." @default.
- W4287377532 created "2022-07-25" @default.
- W4287377532 creator A5003753354 @default.
- W4287377532 creator A5011729658 @default.
- W4287377532 creator A5027876191 @default.
- W4287377532 creator A5050008313 @default.
- W4287377532 creator A5067392576 @default.
- W4287377532 creator A5059685809 @default.
- W4287377532 date "2022-07-25" @default.
- W4287377532 modified "2023-09-25" @default.
- W4287377532 title "Comparative analysis of human and bovine thyroglobulin structures" @default.
- W4287377532 cites W1527267184 @default.
- W4287377532 cites W1964662783 @default.
- W4287377532 cites W1976937534 @default.
- W4287377532 cites W1978408031 @default.
- W4287377532 cites W1978968409 @default.
- W4287377532 cites W1990995713 @default.
- W4287377532 cites W2021520922 @default.
- W4287377532 cites W2048947602 @default.
- W4287377532 cites W2060809301 @default.
- W4287377532 cites W2084465370 @default.
- W4287377532 cites W2097789207 @default.
- W4287377532 cites W2108013176 @default.
- W4287377532 cites W211528354 @default.
- W4287377532 cites W2121272213 @default.
- W4287377532 cites W2124631677 @default.
- W4287377532 cites W2130329013 @default.
- W4287377532 cites W2132629607 @default.
- W4287377532 cites W2138024120 @default.
- W4287377532 cites W2160426811 @default.
- W4287377532 cites W2167255222 @default.
- W4287377532 cites W2169909065 @default.
- W4287377532 cites W2432427150 @default.
- W4287377532 cites W2443984374 @default.
- W4287377532 cites W2786436455 @default.
- W4287377532 cites W2900569176 @default.
- W4287377532 cites W2912598745 @default.
- W4287377532 cites W2949301320 @default.
- W4287377532 cites W2950967305 @default.
- W4287377532 cites W2952828040 @default.
- W4287377532 cites W2969865035 @default.
- W4287377532 cites W2994619903 @default.
- W4287377532 cites W2995946509 @default.
- W4287377532 cites W3004797639 @default.
- W4287377532 cites W3112376646 @default.
- W4287377532 cites W4211128678 @default.
- W4287377532 doi "https://doi.org/10.1186/s40543-022-00330-9" @default.
- W4287377532 hasPublicationYear "2022" @default.
- W4287377532 type Work @default.
- W4287377532 citedByCount "1" @default.
- W4287377532 countsByYear W42873775322023 @default.
- W4287377532 crossrefType "journal-article" @default.
- W4287377532 hasAuthorship W4287377532A5003753354 @default.
- W4287377532 hasAuthorship W4287377532A5011729658 @default.
- W4287377532 hasAuthorship W4287377532A5027876191 @default.
- W4287377532 hasAuthorship W4287377532A5050008313 @default.
- W4287377532 hasAuthorship W4287377532A5059685809 @default.
- W4287377532 hasAuthorship W4287377532A5067392576 @default.
- W4287377532 hasBestOaLocation W42873775321 @default.
- W4287377532 hasConcept C104317684 @default.
- W4287377532 hasConcept C144024400 @default.
- W4287377532 hasConcept C165525559 @default.
- W4287377532 hasConcept C167625842 @default.
- W4287377532 hasConcept C169627665 @default.
- W4287377532 hasConcept C178180057 @default.
- W4287377532 hasConcept C181199279 @default.
- W4287377532 hasConcept C19165224 @default.
- W4287377532 hasConcept C199216141 @default.
- W4287377532 hasConcept C2777938546 @default.
- W4287377532 hasConcept C2778112365 @default.
- W4287377532 hasConcept C2778835679 @default.
- W4287377532 hasConcept C515207424 @default.
- W4287377532 hasConcept C526584372 @default.
- W4287377532 hasConcept C54355233 @default.
- W4287377532 hasConcept C55493867 @default.
- W4287377532 hasConcept C70721500 @default.
- W4287377532 hasConcept C78458016 @default.
- W4287377532 hasConcept C86803240 @default.
- W4287377532 hasConceptScore W4287377532C104317684 @default.
- W4287377532 hasConceptScore W4287377532C144024400 @default.
- W4287377532 hasConceptScore W4287377532C165525559 @default.
- W4287377532 hasConceptScore W4287377532C167625842 @default.
- W4287377532 hasConceptScore W4287377532C169627665 @default.
- W4287377532 hasConceptScore W4287377532C178180057 @default.
- W4287377532 hasConceptScore W4287377532C181199279 @default.
- W4287377532 hasConceptScore W4287377532C19165224 @default.
- W4287377532 hasConceptScore W4287377532C199216141 @default.
- W4287377532 hasConceptScore W4287377532C2777938546 @default.
- W4287377532 hasConceptScore W4287377532C2778112365 @default.
- W4287377532 hasConceptScore W4287377532C2778835679 @default.
- W4287377532 hasConceptScore W4287377532C515207424 @default.
- W4287377532 hasConceptScore W4287377532C526584372 @default.
- W4287377532 hasConceptScore W4287377532C54355233 @default.
- W4287377532 hasConceptScore W4287377532C55493867 @default.
- W4287377532 hasConceptScore W4287377532C70721500 @default.
- W4287377532 hasConceptScore W4287377532C78458016 @default.
- W4287377532 hasConceptScore W4287377532C86803240 @default.
- W4287377532 hasFunder F4320321408 @default.
- W4287377532 hasFunder F4320322107 @default.
- W4287377532 hasFunder F4320322349 @default.