FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4287377828> ?p ?o ?g. }

• W4287377828 endingPage "591" @default.
• W4287377828 startingPage "585" @default.
• W4287377828 abstract "ABSTRACT. Melioidosis is a fatal infectious disease in the tropics and subtropics. Currently, bacterial culture is the gold standard for diagnosis of the disease, but its sensitivity is relatively low. In this study, we evaluated four ELISAs using sera collected from culture-confirmed cases of melioidosis ( n = 63), cases with other bacterial infections ( n = 62), and healthy donors ( n = 60). Antigens used for ELISAs were the whole-cell (WC) antigens and recombinant proteins of hemolysis co-regulated protein 1 (Hcp1), chaperonin GroEL1, and alkyl hydroperoxide reductase subunit C (AhpC). Using the cutoff values for optical density at 490 nm defined at a specificity of > 95%, the sensitivity of the WC, Hcp1, GroEL1, and AhpC ELISAs was 93.7%, 87.3%, 61.9%, and 57.1%, respectively. The combined WC/Hcp1 ELISA showed the greatest sensitivity and specificity of 98.4% and 95.1%, respectively. Of 511 and 500 sera collected from clinically suspected febrile patients admitted to the General Hospital of Ha Tinh Province and the Hue Central Hospital, respectively, combined WC/Hcp1 ELISAs showed 52 (10.2%) and 41 (8.2%) patients positive for melioidosis, respectively. The assay detected 14 of 14 (100%) and 21 of 23 (91.3%) culture-confirmed cases of melioidosis at Ha Tinh and Hue, respectively. A follow-up study of 38 patients positive for melioidosis by combined WC/Hcp1 ELISAs but negative for Burkholderia pseudomallei by culture method or not assigned to examine for bacterial culture resulted in 2 (5.3%) culture-reconfirmed patients with melioidosis, 9 (23.7%) deaths, 17 (44.7%) unhealthy patients, and 10 (26.3%) healthy persons. Combined WC/Hcp1 ELISA was a reliable serological method to detect underdiagnosed cases of melioidosis. Further investigations are needed to estimate the true sensitivity and specificity of the assay and the true number of cases of melioidosis." @default.
• W4287377828 created "2022-07-25" @default.
• W4287377828 creator A5001217426 @default.
• W4287377828 creator A5008898132 @default.
• W4287377828 creator A5010493075 @default.
• W4287377828 creator A5015386417 @default.
• W4287377828 creator A5027702071 @default.
• W4287377828 creator A5030836355 @default.
• W4287377828 creator A5055802354 @default.
• W4287377828 creator A5064602068 @default.
• W4287377828 creator A5071341246 @default.
• W4287377828 creator A5074179375 @default.
• W4287377828 date "2022-09-14" @default.
• W4287377828 modified "2023-09-26" @default.
• W4287377828 title "Clinical Utility of Combined Whole-cell Antigen and Recombinant Hemolysis Co-regulated Protein 1-Enzyme-linked Immunosorbent Assays Reveals Underdiagnosed Cases of Melioidosis in Vietnam" @default.
• W4287377828 cites W1910217541 @default.
• W4287377828 cites W1972058172 @default.
• W4287377828 cites W2014642246 @default.
• W4287377828 cites W2045384215 @default.
• W4287377828 cites W2055308117 @default.
• W4287377828 cites W2063276338 @default.
• W4287377828 cites W2082380501 @default.
• W4287377828 cites W2097358379 @default.
• W4287377828 cites W2101395506 @default.
• W4287377828 cites W2104112831 @default.
• W4287377828 cites W2107966948 @default.
• W4287377828 cites W2111051291 @default.
• W4287377828 cites W2112760723 @default.
• W4287377828 cites W2118377265 @default.
• W4287377828 cites W2123403764 @default.
• W4287377828 cites W2126115162 @default.
• W4287377828 cites W2127510572 @default.
• W4287377828 cites W2148592979 @default.
• W4287377828 cites W2149156757 @default.
• W4287377828 cites W2149615908 @default.
• W4287377828 cites W2345054393 @default.
• W4287377828 cites W2407415576 @default.
• W4287377828 cites W2484427319 @default.
• W4287377828 cites W2526765238 @default.
• W4287377828 cites W2597754506 @default.
• W4287377828 cites W2735251843 @default.
• W4287377828 cites W2744545809 @default.
• W4287377828 cites W2784995650 @default.
• W4287377828 cites W2806613802 @default.
• W4287377828 cites W2897633471 @default.
• W4287377828 cites W2953569229 @default.
• W4287377828 cites W2975467786 @default.
• W4287377828 cites W3042094534 @default.
• W4287377828 cites W3091461558 @default.
• W4287377828 cites W3107249468 @default.
• W4287377828 cites W39430779 @default.
• W4287377828 doi "https://doi.org/10.4269/ajtmh.21-1143" @default.
• W4287377828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35895334" @default.
• W4287377828 hasPublicationYear "2022" @default.
• W4287377828 type Work @default.
• W4287377828 citedByCount "0" @default.
• W4287377828 crossrefType "journal-article" @default.
• W4287377828 hasAuthorship W4287377828A5001217426 @default.
• W4287377828 hasAuthorship W4287377828A5008898132 @default.
• W4287377828 hasAuthorship W4287377828A5010493075 @default.
• W4287377828 hasAuthorship W4287377828A5015386417 @default.
• W4287377828 hasAuthorship W4287377828A5027702071 @default.
• W4287377828 hasAuthorship W4287377828A5030836355 @default.
• W4287377828 hasAuthorship W4287377828A5055802354 @default.
• W4287377828 hasAuthorship W4287377828A5064602068 @default.
• W4287377828 hasAuthorship W4287377828A5071341246 @default.
• W4287377828 hasAuthorship W4287377828A5074179375 @default.
• W4287377828 hasBestOaLocation W42873778281 @default.
• W4287377828 hasConcept C147483822 @default.
• W4287377828 hasConcept C159047783 @default.
• W4287377828 hasConcept C203014093 @default.
• W4287377828 hasConcept C2779110727 @default.
• W4287377828 hasConcept C2779775996 @default.
• W4287377828 hasConcept C523546767 @default.
• W4287377828 hasConcept C54355233 @default.
• W4287377828 hasConcept C71924100 @default.
• W4287377828 hasConcept C86803240 @default.
• W4287377828 hasConcept C89423630 @default.
• W4287377828 hasConceptScore W4287377828C147483822 @default.
• W4287377828 hasConceptScore W4287377828C159047783 @default.
• W4287377828 hasConceptScore W4287377828C203014093 @default.
• W4287377828 hasConceptScore W4287377828C2779110727 @default.
• W4287377828 hasConceptScore W4287377828C2779775996 @default.
• W4287377828 hasConceptScore W4287377828C523546767 @default.
• W4287377828 hasConceptScore W4287377828C54355233 @default.
• W4287377828 hasConceptScore W4287377828C71924100 @default.
• W4287377828 hasConceptScore W4287377828C86803240 @default.
• W4287377828 hasConceptScore W4287377828C89423630 @default.
• W4287377828 hasIssue "3" @default.
• W4287377828 hasLocation W42873778281 @default.
• W4287377828 hasLocation W42873778282 @default.
• W4287377828 hasOpenAccess W4287377828 @default.
• W4287377828 hasPrimaryLocation W42873778281 @default.
• W4287377828 hasRelatedWork W1741143219 @default.
• W4287377828 hasRelatedWork W2053437171 @default.
• W4287377828 hasRelatedWork W2126115162 @default.
• W4287377828 hasRelatedWork W2139700741 @default.
• W4287377828 hasRelatedWork W2590431735 @default.

• next