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• W4287378447 abstract "Abstract The impact of a gluten-free diet (GFD) on screen-detected celiac disease (CD) is currently ambiguous. We aimed to identify the population-based prevalence of undiagnosed adult CD and examine the impact of a GFD on screen-detected CD. In total, 12,981 adults participated in a population-based health study in Tromsø, Norway. Participants with increased levels of anti-tissue transglutaminase-2 IgA or anti-deamidated gliadin peptide IgG were invited to undergo gastroduodenoscopy with both histological and immunohistochemical examination of small-bowel biopsies. The prevalence of previously diagnosed CD was 0.37%. Additionally, the prevalence of previously undiagnosed CD was 1.10%. Thus, 1.47% of the population had CD, of whom 75% were previously undiagnosed. A GFD resulted in significant improvements in overall gastrointestinal symptoms, diarrhea, and health-related quality of life, with reduced abdominal discomfort (76%) and improved levels of energy (58%). The large majority of patients with adult CD were undiagnosed and benefited from a GFD with reduced gastrointestinal symptoms and improved health-related quality of life. In clinical practice, there should be a low threshold for CD testing even in the absence of abdominal complaints because most adult patients appear to consider their symptoms a part of their normal state and therefore remain untested and undiagnosed. Trial registration: Clinical Trials. Gov Identifier: NCT01695681." @default.
• W4287378447 created "2022-07-25" @default.
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• W4287378447 date "2022-07-25" @default.
• W4287378447 modified "2023-10-18" @default.
• W4287378447 title "Population-based screening for celiac disease reveals that the majority of patients are undiagnosed and improve on a gluten-free diet" @default.
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• W4287378447 doi "https://doi.org/10.1038/s41598-022-16705-2" @default.
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