Matches in SemOpenAlex for { <https://semopenalex.org/work/W4287415511> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4287415511 endingPage "13673" @default.
- W4287415511 startingPage "13665" @default.
- W4287415511 abstract "The aim of this study was to elucidate the role of miR-200c-3p in cochlear hair cells injured by oxidative stress (OS) and the underlying mechanisms.The OS injury model of HEI-OC1 cells was induced by 100 μmol/L tert-butyl hydroperoxide (t-BHP). The expression of miR-200c-3p in HEI-OC1 was detected by RT-PCR, the levels of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), Catalase (CAT), and malondialdehyde (MDA) were determined with ELISA, and the expression levels of Taok1 and apoptosis-related proteins were measured by Western Blot. Flow cytometry was used to detect cell apoptosis.Real-time polymerase chain reaction (RT-qPCR) analysis identified down-regulated miR-200c-3p and up-regulated Taok1 in HEI-OC1 cells damaged by OS, as well as an inverse association between miR-200c-3p and Taok1. Cell tests confirmed that miR-200c-3p overexpression could effectively inhibit the OS response and apoptosis of HEI-OC1 cells. Bioinformatics prediction and dual luciferase reporter assay revealed that Taok1 was a direct target of miR-200c-3p. Taok1 overexpression could reverse the protective action of miR-200c-3p overexpression on the OS injury of HEI-OC1 cells.Given the capacity of miR-200c-3p to suppress the OS and apoptosis of HEI-OC1 cells via targeting Taok1, it can be a novel and potential therapeutic target for cochlear hair cell injury." @default.
- W4287415511 created "2022-07-25" @default.
- W4287415511 creator A5059210458 @default.
- W4287415511 creator A5060177975 @default.
- W4287415511 creator A5068754189 @default.
- W4287415511 creator A5073740272 @default.
- W4287415511 creator A5085142351 @default.
- W4287415511 date "2021-01-01" @default.
- W4287415511 modified "2023-09-26" @default.
- W4287415511 title "MiR-200c-3p affects cochlear hair cells damaged by oxidative stress via modulating Taok1 expression." @default.
- W4287415511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35035705" @default.
- W4287415511 hasPublicationYear "2021" @default.
- W4287415511 type Work @default.
- W4287415511 citedByCount "0" @default.
- W4287415511 crossrefType "journal-article" @default.
- W4287415511 hasAuthorship W4287415511A5059210458 @default.
- W4287415511 hasAuthorship W4287415511A5060177975 @default.
- W4287415511 hasAuthorship W4287415511A5068754189 @default.
- W4287415511 hasAuthorship W4287415511A5073740272 @default.
- W4287415511 hasAuthorship W4287415511A5085142351 @default.
- W4287415511 hasConcept C104317684 @default.
- W4287415511 hasConcept C105702510 @default.
- W4287415511 hasConcept C153911025 @default.
- W4287415511 hasConcept C185592680 @default.
- W4287415511 hasConcept C190283241 @default.
- W4287415511 hasConcept C2775838275 @default.
- W4287415511 hasConcept C2776151105 @default.
- W4287415511 hasConcept C2776415932 @default.
- W4287415511 hasConcept C2778401633 @default.
- W4287415511 hasConcept C2778585322 @default.
- W4287415511 hasConcept C2778979269 @default.
- W4287415511 hasConcept C2780130748 @default.
- W4287415511 hasConcept C553184892 @default.
- W4287415511 hasConcept C55493867 @default.
- W4287415511 hasConcept C86803240 @default.
- W4287415511 hasConcept C95444343 @default.
- W4287415511 hasConceptScore W4287415511C104317684 @default.
- W4287415511 hasConceptScore W4287415511C105702510 @default.
- W4287415511 hasConceptScore W4287415511C153911025 @default.
- W4287415511 hasConceptScore W4287415511C185592680 @default.
- W4287415511 hasConceptScore W4287415511C190283241 @default.
- W4287415511 hasConceptScore W4287415511C2775838275 @default.
- W4287415511 hasConceptScore W4287415511C2776151105 @default.
- W4287415511 hasConceptScore W4287415511C2776415932 @default.
- W4287415511 hasConceptScore W4287415511C2778401633 @default.
- W4287415511 hasConceptScore W4287415511C2778585322 @default.
- W4287415511 hasConceptScore W4287415511C2778979269 @default.
- W4287415511 hasConceptScore W4287415511C2780130748 @default.
- W4287415511 hasConceptScore W4287415511C553184892 @default.
- W4287415511 hasConceptScore W4287415511C55493867 @default.
- W4287415511 hasConceptScore W4287415511C86803240 @default.
- W4287415511 hasConceptScore W4287415511C95444343 @default.
- W4287415511 hasIssue "12" @default.
- W4287415511 hasLocation W42874155111 @default.
- W4287415511 hasOpenAccess W4287415511 @default.
- W4287415511 hasPrimaryLocation W42874155111 @default.
- W4287415511 hasRelatedWork W11983721 @default.
- W4287415511 hasRelatedWork W12708080 @default.
- W4287415511 hasRelatedWork W14182041 @default.
- W4287415511 hasRelatedWork W19113225 @default.
- W4287415511 hasRelatedWork W19899870 @default.
- W4287415511 hasRelatedWork W22419451 @default.
- W4287415511 hasRelatedWork W23088233 @default.
- W4287415511 hasRelatedWork W27061035 @default.
- W4287415511 hasRelatedWork W5291502 @default.
- W4287415511 hasRelatedWork W8610565 @default.
- W4287415511 hasVolume "13" @default.
- W4287415511 isParatext "false" @default.
- W4287415511 isRetracted "false" @default.
- W4287415511 workType "article" @default.