Matches in SemOpenAlex for { <https://semopenalex.org/work/W4287447441> ?p ?o ?g. }
- W4287447441 abstract "Extracellular vesicles (EVs) are particles naturally released from cells that are delimited by a lipid bilayer and are unable to replicate. How the EVs cross the Blood-Brain barrier (BBB) in a bidirectional manner between the bloodstream and brain parenchyma remains poorly understood. Most in vitro models that have evaluated this event have relied on monolayer transwell or microfluidic organ-on-a-chip techniques that do not account for the combined effect of all cellular layers that constitute the BBB at different sites of the Central Nervous System. There has not been direct transcytosis visualization through the BBB in mammals in vivo, and evidence comes from in vivo experiments in zebrafish. Literature is scarce on this topic, and techniques describing the mechanisms of EVs motion through the BBB are inconsistent. This review will focus on in vitro and in vivo methodologies used to evaluate EVs transcytosis, how EVs overcome this fundamental structure, and discuss potential methodological approaches for future analyses to clarify these issues. Understanding how EVs cross the BBB will be essential for their future use as vehicles in pharmacology and therapeutics." @default.
- W4287447441 created "2022-07-25" @default.
- W4287447441 creator A5026469451 @default.
- W4287447441 creator A5048599897 @default.
- W4287447441 creator A5054944543 @default.
- W4287447441 creator A5060958131 @default.
- W4287447441 creator A5064574268 @default.
- W4287447441 creator A5089769408 @default.
- W4287447441 creator A5091457383 @default.
- W4287447441 date "2022-07-25" @default.
- W4287447441 modified "2023-10-18" @default.
- W4287447441 title "Extracellular vesicles through the blood–brain barrier: a review" @default.
- W4287447441 cites W1542448731 @default.
- W4287447441 cites W1574663134 @default.
- W4287447441 cites W1587711235 @default.
- W4287447441 cites W1588685142 @default.
- W4287447441 cites W1771394546 @default.
- W4287447441 cites W1965913620 @default.
- W4287447441 cites W1968199365 @default.
- W4287447441 cites W1977413601 @default.
- W4287447441 cites W1978228117 @default.
- W4287447441 cites W1982499150 @default.
- W4287447441 cites W1985458075 @default.
- W4287447441 cites W1989274589 @default.
- W4287447441 cites W1995903088 @default.
- W4287447441 cites W1998099768 @default.
- W4287447441 cites W1999588620 @default.
- W4287447441 cites W1999866221 @default.
- W4287447441 cites W2000034106 @default.
- W4287447441 cites W2003555906 @default.
- W4287447441 cites W2013017425 @default.
- W4287447441 cites W2013540034 @default.
- W4287447441 cites W2015541518 @default.
- W4287447441 cites W2025199750 @default.
- W4287447441 cites W2039568446 @default.
- W4287447441 cites W2044389563 @default.
- W4287447441 cites W2055452454 @default.
- W4287447441 cites W2070307875 @default.
- W4287447441 cites W2074782193 @default.
- W4287447441 cites W2091684966 @default.
- W4287447441 cites W2099161811 @default.
- W4287447441 cites W2104869587 @default.
- W4287447441 cites W2105213856 @default.
- W4287447441 cites W2121354606 @default.
- W4287447441 cites W2123039682 @default.
- W4287447441 cites W2125411036 @default.
- W4287447441 cites W2128620821 @default.
- W4287447441 cites W2134921841 @default.
- W4287447441 cites W2290775492 @default.
- W4287447441 cites W2294317040 @default.
- W4287447441 cites W2324292575 @default.
- W4287447441 cites W2337269107 @default.
- W4287447441 cites W2350344017 @default.
- W4287447441 cites W2352124481 @default.
- W4287447441 cites W2465939084 @default.
- W4287447441 cites W2552202354 @default.
- W4287447441 cites W2554880605 @default.
- W4287447441 cites W2563707948 @default.
- W4287447441 cites W2587367660 @default.
- W4287447441 cites W2601584926 @default.
- W4287447441 cites W2616981115 @default.
- W4287447441 cites W2624368609 @default.
- W4287447441 cites W2708242294 @default.
- W4287447441 cites W2754129305 @default.
- W4287447441 cites W2756085402 @default.
- W4287447441 cites W2761229854 @default.
- W4287447441 cites W2761598264 @default.
- W4287447441 cites W2766786165 @default.
- W4287447441 cites W2771557629 @default.
- W4287447441 cites W2792111677 @default.
- W4287447441 cites W2800781066 @default.
- W4287447441 cites W2803997637 @default.
- W4287447441 cites W2898415565 @default.
- W4287447441 cites W2898829113 @default.
- W4287447441 cites W2900532810 @default.
- W4287447441 cites W2900756811 @default.
- W4287447441 cites W2904651621 @default.
- W4287447441 cites W2906563695 @default.
- W4287447441 cites W2909275177 @default.
- W4287447441 cites W2924762180 @default.
- W4287447441 cites W2931418311 @default.
- W4287447441 cites W2953383090 @default.
- W4287447441 cites W2956865263 @default.
- W4287447441 cites W2962176767 @default.
- W4287447441 cites W2969620539 @default.
- W4287447441 cites W2972005444 @default.
- W4287447441 cites W2990475843 @default.
- W4287447441 cites W3011689356 @default.
- W4287447441 cites W3036596408 @default.
- W4287447441 cites W3080613967 @default.
- W4287447441 cites W3105982350 @default.
- W4287447441 cites W3113313210 @default.
- W4287447441 cites W3126130796 @default.
- W4287447441 cites W3129277418 @default.
- W4287447441 cites W3151307822 @default.
- W4287447441 cites W3170543539 @default.
- W4287447441 cites W3194903444 @default.
- W4287447441 cites W4248881988 @default.
- W4287447441 cites W57587113 @default.
- W4287447441 doi "https://doi.org/10.1186/s12987-022-00359-3" @default.