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• W4287448281 startingPage "1" @default.
• W4287448281 abstract "Cartilage repair strategies are evolving at a fast pace with technology development. Matrices that offer multifaceted functions and a full adaption to the cartilage defect are of pivotal interest. Current cartilage repair strategies face numerous challenges, mostly related to the development of highly biomimetic materials, non-invasive injectable solutions, and adequate degradation rates. These strategies often fail due to feeble mechanical properties, the inability to sustain cell adhesion, growth, and differentiation or by underestimating other players of cartilage degeneration, such as the installed pro-inflammatory microenvironment. The integration of nanomaterials (NMs) into 3D scaffolds, hydrogels and bioinks hold great potential in the improvement of key features of materials that are currently applied in cartilage tissue engineering. NMs offer a high surface to volume ratio and their multiple applications can be explored to enhance cartilage mechanical properties, biocompatibility, cell differentiation, inflammation modulation, infection prevention and even to function as diagnostic tools or as stimuli-responsive cues in these 3D structures. In this review, we have critically reviewed the latest advances in the development of nanoenabled 3D matrices - enhanced by means of NMs - in the context of cartilage regeneration. We have provided a wide perspective of the synergistic effect of combining 3D strategies with NMs, with emphasis on the benefits brought by NMs in achieving functional and enhanced therapeutic outcomes. STATEMENT OF SIGNIFICANCE: Cartilage is one of the most challenging tissues to treat owing to its limited self-regeneration potential. Novel strategies using nanoenabled 3D matrices have emerged from the need to design more efficient solutions for cartilage repair, that take into consideration its unique mechanical properties and can direct specific cell behaviours. Here we aim to provide a comprehensive review on the synergistic effects of 3D matrices nanoenrichment in the context of cartilage regeneration, with emphasis on the heightening brought by nanomaterials in achieving functional and enhanced therapeutic outcomes. We anticipate this review to provide a wide perspective on the past years' research on the field, demonstrating the great potential of these approaches in the treatment and diagnosis of cartilage-related disorders." @default.
• W4287448281 created "2022-07-25" @default.
• W4287448281 creator A5010618743 @default.
• W4287448281 creator A5041458969 @default.
• W4287448281 creator A5078520359 @default.
• W4287448281 date "2022-09-01" @default.
• W4287448281 modified "2023-09-30" @default.
• W4287448281 title "Advances in nanoenabled 3D matrices for cartilage repair" @default.
• W4287448281 cites W1226304484 @default.
• W4287448281 cites W1528604920 @default.
• W4287448281 cites W1608451876 @default.
• W4287448281 cites W1727854595 @default.
• W4287448281 cites W1830318073 @default.
• W4287448281 cites W1965338671 @default.
• W4287448281 cites W1972969791 @default.
• W4287448281 cites W1974193257 @default.
• W4287448281 cites W1976046838 @default.
• W4287448281 cites W1980800152 @default.
• W4287448281 cites W1982414211 @default.
• W4287448281 cites W1982769493 @default.
• W4287448281 cites W1983565614 @default.
• W4287448281 cites W1985508401 @default.
• W4287448281 cites W1994903148 @default.
• W4287448281 cites W1995747866 @default.
• W4287448281 cites W2000163264 @default.
• W4287448281 cites W2008092117 @default.
• W4287448281 cites W2011038175 @default.
• W4287448281 cites W2016140679 @default.
• W4287448281 cites W2026630459 @default.
• W4287448281 cites W2029702180 @default.
• W4287448281 cites W2031844423 @default.
• W4287448281 cites W2032362610 @default.
• W4287448281 cites W2038987199 @default.
• W4287448281 cites W2042553094 @default.
• W4287448281 cites W2042709468 @default.
• W4287448281 cites W2048227994 @default.
• W4287448281 cites W2054250836 @default.
• W4287448281 cites W2057324851 @default.
• W4287448281 cites W2060958484 @default.
• W4287448281 cites W2073294682 @default.
• W4287448281 cites W2077607728 @default.
• W4287448281 cites W2078639867 @default.
• W4287448281 cites W2080516615 @default.
• W4287448281 cites W2084610464 @default.
• W4287448281 cites W2086457671 @default.
• W4287448281 cites W2095056299 @default.
• W4287448281 cites W2095090773 @default.
• W4287448281 cites W2104183860 @default.
• W4287448281 cites W2109966590 @default.
• W4287448281 cites W2122172801 @default.
• W4287448281 cites W2132010023 @default.
• W4287448281 cites W2135799879 @default.
• W4287448281 cites W2137620557 @default.
• W4287448281 cites W2142801671 @default.
• W4287448281 cites W2148491656 @default.
• W4287448281 cites W2153320120 @default.
• W4287448281 cites W2153486138 @default.
• W4287448281 cites W2160354233 @default.
• W4287448281 cites W2161897788 @default.
• W4287448281 cites W2169038586 @default.
• W4287448281 cites W2169664042 @default.
• W4287448281 cites W2212591549 @default.
• W4287448281 cites W2220721009 @default.
• W4287448281 cites W2227418119 @default.
• W4287448281 cites W2235286313 @default.
• W4287448281 cites W2298897662 @default.
• W4287448281 cites W2337626939 @default.
• W4287448281 cites W2493233200 @default.
• W4287448281 cites W2500804873 @default.
• W4287448281 cites W2528088648 @default.
• W4287448281 cites W2531406896 @default.
• W4287448281 cites W2569469282 @default.
• W4287448281 cites W2588922129 @default.
• W4287448281 cites W2601097860 @default.
• W4287448281 cites W2603374651 @default.
• W4287448281 cites W2613021314 @default.
• W4287448281 cites W2620435339 @default.
• W4287448281 cites W2730852043 @default.
• W4287448281 cites W2744149796 @default.
• W4287448281 cites W2757652705 @default.
• W4287448281 cites W2759173242 @default.
• W4287448281 cites W2768047406 @default.
• W4287448281 cites W2770471347 @default.
• W4287448281 cites W2773693724 @default.
• W4287448281 cites W2774500577 @default.
• W4287448281 cites W2776848829 @default.
• W4287448281 cites W2788738685 @default.
• W4287448281 cites W2789470559 @default.
• W4287448281 cites W2790281145 @default.
• W4287448281 cites W2791055483 @default.
• W4287448281 cites W2792255758 @default.
• W4287448281 cites W2792890218 @default.
• W4287448281 cites W2794275420 @default.
• W4287448281 cites W2799739706 @default.
• W4287448281 cites W2799910595 @default.
• W4287448281 cites W2800195470 @default.
• W4287448281 cites W2807397788 @default.
• W4287448281 cites W2885484867 @default.

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