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• W4287448488 endingPage "117" @default.
• W4287448488 startingPage "104" @default.
• W4287448488 abstract "• Mice with heterozygous deletion of CaMKIIα gene were hypoactive and displayed less anxiety-like behavior. • CaMKIIα-hKO mice displayed strong impairments in long term memory. • CaMKIIα-hKO mice had increased amplitude of late component ERPs and prolonged latency. • CaMKIIα-hKO mice showed increased amplitude of theta frequency oscillations. • CaMKIIα-hKO mice displayed spontaneous spike wave bursts. Cognitive deficit remains an intractable symptom of schizophrenia, accounting for substantial disability. Despite this, little is known about the cause of cognitive dysfunction in schizophrenia. Recent studies suggest that schizophrenia patients show several changes in dentate gyrus structure and functional characteristic of immaturity. The immature dentate gyrus (iDG) has been replicated in several mouse models, most notably the CaMKIIα heterozygous mouse (CaMKIIα-hKO). The current study characterizes behavioral phenotypes of CaMKIIα-hKO mice and determines their neurophysiological profile using electroencephalogram (EEG) recording from hippocampus. CaMKIIα-hKO mice were hypoactive in home-cage environment; however, they displayed less anxiety-like phenotype, suggestive of impulsivity-like behavior. In addition, severe cognitive dysfunction was evident in CaMKIIα-hKO mice as examined by novel object recognition and contextual fear conditioning. Several EEG phenomena established in both patients and relevant animal models indicate key pathological changes associated with the disease, include auditory event-related potentials and time–frequency EEG oscillations. CaMKIIα-hKO mice showed altered event-related potentials characterized by an increase in amplitude of the N40 and P80, as well as increased P80 latency. These mice also showed increased power in theta range time–frequency measures. Additionally, CaMKIIα-hKO mice showed spontaneous bursts of spike wave activity, possibly indicating absence seizures. The GABAB agonist baclofen increased, while the GABAB antagonist CGP35348 and the T-Type Ca2 + channel blocker Ethosuximide decreased spike wave burst frequency. None of these changes in event-related potentials or EEG oscillations are characteristic of those observed in general population of patients with schizophrenia; yet, CaMKIIα-hKO mice likely model a subpopulation of patients with schizophrenia." @default.
• W4287448488 created "2022-07-25" @default.
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• W4287448488 date "2022-09-01" @default.
• W4287448488 modified "2023-09-26" @default.
• W4287448488 title "Calcium/calmodulin-dependent protein kinase IIα heterozygous knockout mice show electroencephalogram and behavioral changes characteristic of a subpopulation of schizophrenia and intellectual impairment" @default.
• W4287448488 cites W1541267199 @default.
• W4287448488 cites W1601118423 @default.
• W4287448488 cites W1616286551 @default.
• W4287448488 cites W1796178200 @default.
• W4287448488 cites W1937784482 @default.
• W4287448488 cites W1962848600 @default.
• W4287448488 cites W1966303469 @default.
• W4287448488 cites W1966901951 @default.
• W4287448488 cites W1975784530 @default.
• W4287448488 cites W1979565242 @default.
• W4287448488 cites W1980576528 @default.
• W4287448488 cites W1983433412 @default.
• W4287448488 cites W1991726755 @default.
• W4287448488 cites W1991748689 @default.
• W4287448488 cites W2000104590 @default.
• W4287448488 cites W2000396469 @default.
• W4287448488 cites W2001896608 @default.
• W4287448488 cites W2009506821 @default.
• W4287448488 cites W2013560440 @default.
• W4287448488 cites W2015738723 @default.
• W4287448488 cites W2017750602 @default.
• W4287448488 cites W2020588188 @default.
• W4287448488 cites W2025293038 @default.
• W4287448488 cites W2027720046 @default.
• W4287448488 cites W2030179847 @default.
• W4287448488 cites W2030308305 @default.
• W4287448488 cites W203174961 @default.
• W4287448488 cites W2033433729 @default.
• W4287448488 cites W2033509631 @default.
• W4287448488 cites W2035880579 @default.
• W4287448488 cites W2036441297 @default.
• W4287448488 cites W2037923840 @default.
• W4287448488 cites W2040856053 @default.
• W4287448488 cites W2042036678 @default.
• W4287448488 cites W2044981785 @default.
• W4287448488 cites W2048079797 @default.
• W4287448488 cites W2049741234 @default.
• W4287448488 cites W2051288897 @default.
• W4287448488 cites W2054450240 @default.
• W4287448488 cites W2056071671 @default.
• W4287448488 cites W2068841959 @default.
• W4287448488 cites W2081976119 @default.
• W4287448488 cites W2088105511 @default.
• W4287448488 cites W2092284040 @default.
• W4287448488 cites W2093795230 @default.
• W4287448488 cites W2095105882 @default.
• W4287448488 cites W2096084847 @default.
• W4287448488 cites W2104189327 @default.
• W4287448488 cites W2104347649 @default.
• W4287448488 cites W2111096089 @default.
• W4287448488 cites W2117357872 @default.
• W4287448488 cites W2120257505 @default.
• W4287448488 cites W2121082411 @default.
• W4287448488 cites W2123128031 @default.
• W4287448488 cites W2123485468 @default.
• W4287448488 cites W2128495200 @default.
• W4287448488 cites W2130394290 @default.
• W4287448488 cites W2135278585 @default.
• W4287448488 cites W2141787834 @default.
• W4287448488 cites W2146521940 @default.
• W4287448488 cites W2158350175 @default.
• W4287448488 cites W2184364263 @default.
• W4287448488 cites W2305003644 @default.
• W4287448488 cites W2330883635 @default.
• W4287448488 cites W2396439512 @default.
• W4287448488 cites W2467262680 @default.
• W4287448488 cites W2522618573 @default.
• W4287448488 cites W2582611176 @default.
• W4287448488 cites W2587835308 @default.
• W4287448488 cites W2615474375 @default.
• W4287448488 cites W2618155558 @default.
• W4287448488 cites W2725134083 @default.
• W4287448488 cites W2740567966 @default.
• W4287448488 cites W2740977377 @default.
• W4287448488 cites W2747744205 @default.
• W4287448488 cites W2766594096 @default.
• W4287448488 cites W2766852890 @default.
• W4287448488 cites W2778481566 @default.
• W4287448488 cites W2787829706 @default.
• W4287448488 cites W2788560389 @default.
• W4287448488 cites W2788875125 @default.
• W4287448488 cites W2789974830 @default.
• W4287448488 cites W2792913800 @default.

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