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• W4287448965 endingPage "106615" @default.
• W4287448965 startingPage "106615" @default.
• W4287448965 abstract "Trichinella spiralis is a very successful parasite capable of surviving in many mammal hosts and residing in muscle tissues for long periods, indicating that it must have some effective strategies to escape from or guard against the host immune attack. The functions of MIF have been studied in other parasites and demonstrated to function as a virulence factor aiding in their survival by modulating the host immune response. However, the functions of Trichinella spiralis MIF (TsMIF) have not been addressed. Here, we successfully obtained the purified recombinant TsMIF and anti-TsMIF serum. Our results showed that TsMIF was expressed in all the Trichinella spiralis developmental stages, especially highly expressed in the muscle larvae (ML) and mainly located in stichocytes, midgut, cuticle, muscle cells of ML and around intrauterine embryos of female adults. We also observed TsMIF could be secreted from ML and bind to host monocytes. Next, our data demonstrated that TsMIF not only stimulated the phosphorylation of ERK1/2 and cell proliferation by binding to the host cell surface receptor CD74, but also interacted with a host intracellular protein, Jab1, which is a coactivator of AP-1 transcription. We concluded the secreted TsMIF plays an important role in the interaction between Trichinella spiralis and its host and could be a potential drug or vaccine target molecule against Trichinella spiralis infection." @default.
• W4287448965 created "2022-07-25" @default.
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• W4287448965 date "2022-10-01" @default.
• W4287448965 modified "2023-10-18" @default.
• W4287448965 title "A secreted MIF homologue from Trichinella spiralis binds to and interacts with host monocytes" @default.
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• W4287448965 doi "https://doi.org/10.1016/j.actatropica.2022.106615" @default.
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