FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4287455831> ?p ?o ?g. }

• W4287455831 endingPage "7731" @default.
• W4287455831 startingPage "7717" @default.
• W4287455831 abstract "The development of an injectable multifunctional hydrogel with tumor therapy, antibacterial treatment and wound healing properties is essential for simultaneously eradicating melanoma and promoting wound healing of tumor-initiated skin defects. Herein, iron ion-doped polyaniline (PANI(Fe)) tethered with guar gum (GG) chains is employed for the first time as a building unit for constructing a superior hydrogel (GG@PANI(Fe)-borax) crosslinked by borate/didiol bonds. Due to the dynamic and reversible properties of boronate ester bonds, the GG@PANI(Fe)-borax hydrogels had convenient injectability, rapid self-healing ability, and reversible gel-sol transformations under thermal- or pH-stimuli. More importantly, they took advantage of the second near-infrared (NIR-II) responsive photothermal conversion capability, accompanied by the photothermal-enhanced high cytotoxic ˙OH generation in the H2O2-enriched tumor microenvironment induced by iron-doped PANI. The as-prepared hydrogels exhibited excellent photothermal effects and controllable NIR-triggered drug release, leading to distinctly synergistic photothermal/chemodynamic/chemo-therapy effects of melanoma both in vitro (98.2%) and in vivo (98.8%). In addition, the obtained hydrogels also exhibited good anti-bacterial activity (>97.1%) against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria because they were based on PANI(Fe) and borax, which exhibit antibacterial activity. Furthermore, these GG@PANI(Fe)-incorporated scaffolds could improve fibroblast cell proliferation and angiogenesis for accelerating wound repair in tumor-bearing and infected wound mice. Taken together, GG@PANI(Fe)-borax hydrogels may be used simultaneously for eradication of skin-tumor cells, inhibiting infection and accelerating wound healing. This work offers an effective and facile strategy to fabricate an all-in-one multifunctional hydrogel platform for synergetic multimodal integrated therapy of tumors." @default.
• W4287455831 created "2022-07-25" @default.
• W4287455831 creator A5001777432 @default.
• W4287455831 creator A5002778786 @default.
• W4287455831 creator A5006521384 @default.
• W4287455831 creator A5008383262 @default.
• W4287455831 creator A5013878126 @default.
• W4287455831 creator A5016433953 @default.
• W4287455831 creator A5046297097 @default.
• W4287455831 creator A5062515376 @default.
• W4287455831 creator A5064826355 @default.
• W4287455831 creator A5071773009 @default.
• W4287455831 date "2022-01-01" @default.
• W4287455831 modified "2023-10-16" @default.
• W4287455831 title "A NIR-II light-modulated injectable self-healing hydrogel for synergistic photothermal/chemodynamic/chemo-therapy of melanoma and wound healing promotion" @default.
• W4287455831 cites W1758108669 @default.
• W4287455831 cites W1965857294 @default.
• W4287455831 cites W2008515510 @default.
• W4287455831 cites W2078353661 @default.
• W4287455831 cites W2303693337 @default.
• W4287455831 cites W2501261286 @default.
• W4287455831 cites W2563017121 @default.
• W4287455831 cites W2610674279 @default.
• W4287455831 cites W2738681986 @default.
• W4287455831 cites W2889596782 @default.
• W4287455831 cites W2894668217 @default.
• W4287455831 cites W2905758936 @default.
• W4287455831 cites W2909806759 @default.
• W4287455831 cites W2912211339 @default.
• W4287455831 cites W2912310363 @default.
• W4287455831 cites W2920951163 @default.
• W4287455831 cites W2926385830 @default.
• W4287455831 cites W2930079038 @default.
• W4287455831 cites W2951532990 @default.
• W4287455831 cites W2951809359 @default.
• W4287455831 cites W2955661759 @default.
• W4287455831 cites W2960272185 @default.
• W4287455831 cites W2970776894 @default.
• W4287455831 cites W2994044597 @default.
• W4287455831 cites W3003552929 @default.
• W4287455831 cites W3004528163 @default.
• W4287455831 cites W3006459702 @default.
• W4287455831 cites W3018302685 @default.
• W4287455831 cites W3019619833 @default.
• W4287455831 cites W3048727725 @default.
• W4287455831 cites W3048910908 @default.
• W4287455831 cites W3080937517 @default.
• W4287455831 cites W3139401044 @default.
• W4287455831 cites W3159901019 @default.
• W4287455831 cites W3161725214 @default.
• W4287455831 cites W3163698309 @default.
• W4287455831 cites W3164709722 @default.
• W4287455831 cites W3173167628 @default.
• W4287455831 cites W3174114605 @default.
• W4287455831 cites W3175327718 @default.
• W4287455831 cites W3178925618 @default.
• W4287455831 cites W3182786507 @default.
• W4287455831 cites W3184067836 @default.
• W4287455831 cites W3185046783 @default.
• W4287455831 cites W3185859847 @default.
• W4287455831 cites W3186614151 @default.
• W4287455831 cites W3187682842 @default.
• W4287455831 cites W3210092577 @default.
• W4287455831 cites W4200177522 @default.
• W4287455831 cites W4210285354 @default.
• W4287455831 cites W4211003453 @default.
• W4287455831 cites W4220729844 @default.
• W4287455831 cites W4221071639 @default.
• W4287455831 doi "https://doi.org/10.1039/d2tb00923d" @default.
• W4287455831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35920389" @default.
• W4287455831 hasPublicationYear "2022" @default.
• W4287455831 type Work @default.
• W4287455831 citedByCount "6" @default.
• W4287455831 countsByYear W42874558312023 @default.
• W4287455831 crossrefType "journal-article" @default.
• W4287455831 hasAuthorship W4287455831A5001777432 @default.
• W4287455831 hasAuthorship W4287455831A5002778786 @default.
• W4287455831 hasAuthorship W4287455831A5006521384 @default.
• W4287455831 hasAuthorship W4287455831A5008383262 @default.
• W4287455831 hasAuthorship W4287455831A5013878126 @default.
• W4287455831 hasAuthorship W4287455831A5016433953 @default.
• W4287455831 hasAuthorship W4287455831A5046297097 @default.
• W4287455831 hasAuthorship W4287455831A5062515376 @default.
• W4287455831 hasAuthorship W4287455831A5064826355 @default.
• W4287455831 hasAuthorship W4287455831A5071773009 @default.
• W4287455831 hasConcept C108586683 @default.
• W4287455831 hasConcept C12554922 @default.
• W4287455831 hasConcept C136229726 @default.
• W4287455831 hasConcept C150903083 @default.
• W4287455831 hasConcept C171250308 @default.
• W4287455831 hasConcept C178790620 @default.
• W4287455831 hasConcept C182606246 @default.
• W4287455831 hasConcept C185592680 @default.
• W4287455831 hasConcept C188027245 @default.
• W4287455831 hasConcept C192562407 @default.
• W4287455831 hasConcept C203014093 @default.
• W4287455831 hasConcept C206139338 @default.
• W4287455831 hasConcept C207001950 @default.

• next