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- W4287612282 abstract "Humans, domestic animals, orchard crops, and ornamental plants are commonly treated with antibiotics in response to bacterial infection. By curing infectious individuals, antibiotic therapy might limit the spread of contagious disease among hosts. But an antibiotic`s suppression of within-host pathogen density might also reduce the probability that the host is otherwise removed from infectious status prior to therapeutic recovery. When rates of both recovery via treatment and other removal events (e.g., isolation or mortality) depend directly on within-host pathogen density, antibiotic treatment can relax the overall removal rate sufficiently to increase between-host disease transmission. To explore this dependence, a deterministic within-host dynamics drives the infectious host's time-dependent probability of disease transmission, as well as the probabilistic duration of the infectious period. At the within-host scale, the model varies (1) inoculum size, (2) bacterial self-regulation, (3) the time between infection and initiation of therapy, and (4) antibiotic efficacy. At the between-host scale the model varies (5) the size/susceptibility of groups randomly encountered by an infectious host. Results identify conditions where antibiotic treatment can increase duration of a host`s infectiousness, and consequently increase the expected number of new infections. At lower antibiotic efficacy, treatment might convert a rare, serious bacterial disease into a common, but treatable infection." @default.
- W4287612282 created "2022-07-25" @default.
- W4287612282 creator A5064677787 @default.
- W4287612282 date "2020-11-02" @default.
- W4287612282 modified "2023-09-24" @default.
- W4287612282 title "Antibiotic treatment, duration of infectiousness, and disease transmission" @default.
- W4287612282 doi "https://doi.org/10.48550/arxiv.2011.01548" @default.
- W4287612282 hasPublicationYear "2020" @default.
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