Matches in SemOpenAlex for { <https://semopenalex.org/work/W4287619317> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4287619317 abstract "The emergence of multidrug resistance in uropathogenic Escherichia coli (UPEC) is associated with the presence of drug resistant plasmids and integrons which facilitate horizontal gene transfer which impose serious challenges in patients with urinary tract infections (UTIs). The proposed research study is designed to determine emerging antibiotic resistance trends and the presence of plasmids and class 1 integron in UPEC. A total 74 strains of urinary pathogens were procured among them 50 UPEC isolates were selected and their antibiotic resistance pattern was performed by CLSI guidelines. Plasmid DNA of UPEC strains was extracted by kit method and profiling was done using gel electrophoresis. Class 1 integron genes intI1, sul1 and qacEΔ1 were detected by multiplex PCR in UPEC. Among gram negative urinary isolates, 50 (68%) isolates were E. coli, while the rest were Klebsiella, Pseudomonas, Enterobacter etc. All the tested UPEC were totally resistant to quinolones while sensitive to fosfomycin, imipenem and colistin antibiotics. Majority of multidrug resistant UPEC showed common resistant phenotype of fluoroquinolones, cephalosporins, sulfamethoxazole/trimethoprim and aminoglycosides. Out of the 50 UPEC isolates 46 (92%) were multi-drug resistant having one to three plasmids of more than 1kb and 41 (82%) possessed class 1 integron genes. Over all association between antibiotic resistance and presence of class 1 integron genes showed statistically significant results (p<0.05). Our results also depict a strong correlation between multidrug resistance and presence of class 1 integron in UPEC isolates (p<0.05). The presence of multiple plasmid bands in MDR E. coli strains and high prevalence of class 1 integrons indicate the role of plasmids and integrons in the horizontal transmission of antibiotic resistance genes in UPEC." @default.
- W4287619317 created "2022-07-25" @default.
- W4287619317 creator A5030234955 @default.
- W4287619317 creator A5047663243 @default.
- W4287619317 creator A5071421716 @default.
- W4287619317 date "2020-11-01" @default.
- W4287619317 modified "2023-10-16" @default.
- W4287619317 title "Study of class 1 integrons and plasmid profile among multiple drug resistant uropathogenic Escherichia coli." @default.
- W4287619317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33867342" @default.
- W4287619317 hasPublicationYear "2020" @default.
- W4287619317 type Work @default.
- W4287619317 citedByCount "2" @default.
- W4287619317 countsByYear W42876193172022 @default.
- W4287619317 crossrefType "journal-article" @default.
- W4287619317 hasAuthorship W4287619317A5030234955 @default.
- W4287619317 hasAuthorship W4287619317A5047663243 @default.
- W4287619317 hasAuthorship W4287619317A5071421716 @default.
- W4287619317 hasConcept C10147152 @default.
- W4287619317 hasConcept C104317684 @default.
- W4287619317 hasConcept C114851261 @default.
- W4287619317 hasConcept C133936738 @default.
- W4287619317 hasConcept C22744801 @default.
- W4287619317 hasConcept C2775876089 @default.
- W4287619317 hasConcept C2776650774 @default.
- W4287619317 hasConcept C2778897966 @default.
- W4287619317 hasConcept C2779631663 @default.
- W4287619317 hasConcept C501593827 @default.
- W4287619317 hasConcept C54355233 @default.
- W4287619317 hasConcept C547475151 @default.
- W4287619317 hasConcept C86803240 @default.
- W4287619317 hasConcept C89423630 @default.
- W4287619317 hasConcept C94665300 @default.
- W4287619317 hasConceptScore W4287619317C10147152 @default.
- W4287619317 hasConceptScore W4287619317C104317684 @default.
- W4287619317 hasConceptScore W4287619317C114851261 @default.
- W4287619317 hasConceptScore W4287619317C133936738 @default.
- W4287619317 hasConceptScore W4287619317C22744801 @default.
- W4287619317 hasConceptScore W4287619317C2775876089 @default.
- W4287619317 hasConceptScore W4287619317C2776650774 @default.
- W4287619317 hasConceptScore W4287619317C2778897966 @default.
- W4287619317 hasConceptScore W4287619317C2779631663 @default.
- W4287619317 hasConceptScore W4287619317C501593827 @default.
- W4287619317 hasConceptScore W4287619317C54355233 @default.
- W4287619317 hasConceptScore W4287619317C547475151 @default.
- W4287619317 hasConceptScore W4287619317C86803240 @default.
- W4287619317 hasConceptScore W4287619317C89423630 @default.
- W4287619317 hasConceptScore W4287619317C94665300 @default.
- W4287619317 hasLocation W42876193171 @default.
- W4287619317 hasOpenAccess W4287619317 @default.
- W4287619317 hasPrimaryLocation W42876193171 @default.
- W4287619317 hasRelatedWork W21129404 @default.
- W4287619317 hasRelatedWork W25675676 @default.
- W4287619317 hasRelatedWork W27118221 @default.
- W4287619317 hasRelatedWork W27410307 @default.
- W4287619317 hasRelatedWork W29037172 @default.
- W4287619317 hasRelatedWork W32898775 @default.
- W4287619317 hasRelatedWork W36631143 @default.
- W4287619317 hasRelatedWork W41589069 @default.
- W4287619317 hasRelatedWork W5383056 @default.
- W4287619317 hasRelatedWork W14649078 @default.
- W4287619317 isParatext "false" @default.
- W4287619317 isRetracted "false" @default.
- W4287619317 workType "article" @default.