Matches in SemOpenAlex for { <https://semopenalex.org/work/W4287736975> ?p ?o ?g. }
- W4287736975 abstract "Abstract Sexual dimorphism in complex traits is suspected to be in part due to widespread gene-by-sex interactions (GxSex), but empirical evidence has been elusive. Here, we infer the mixture of ways polygenic effects on physiological traits covary between males and females. We find that GxSex is pervasive but acts primarily through systematic sex differences in the magnitude of many genetic effects (“amplification”), rather than in the identity of causal variants. Amplification patterns account for sex differences in trait variance. In some cases, testosterone may mediate amplification. Finally, we develop a population-genetic test linking GxSex to contemporary natural selection and find evidence for sexually antagonistic selection on variants affecting testosterone levels. Taken together, our results suggest that the amplification of polygenic effects is a common mode of GxSex that may contribute to sex differences and fuel their evolution. Abstract Figure" @default.
- W4287736975 created "2022-07-26" @default.
- W4287736975 creator A5003885949 @default.
- W4287736975 creator A5006553079 @default.
- W4287736975 creator A5026013829 @default.
- W4287736975 creator A5062614876 @default.
- W4287736975 creator A5089733345 @default.
- W4287736975 date "2022-05-08" @default.
- W4287736975 modified "2023-10-18" @default.
- W4287736975 title "Amplification is the Primary Mode of Gene-by-Sex Interaction in Complex Human Traits" @default.
- W4287736975 cites W1897181085 @default.
- W4287736975 cites W2002085685 @default.
- W4287736975 cites W2027144933 @default.
- W4287736975 cites W2027431314 @default.
- W4287736975 cites W2029957476 @default.
- W4287736975 cites W2034813336 @default.
- W4287736975 cites W2066136628 @default.
- W4287736975 cites W2073640336 @default.
- W4287736975 cites W2082704080 @default.
- W4287736975 cites W2098510562 @default.
- W4287736975 cites W2106036991 @default.
- W4287736975 cites W2108413990 @default.
- W4287736975 cites W2108584487 @default.
- W4287736975 cites W2108833696 @default.
- W4287736975 cites W2118235054 @default.
- W4287736975 cites W2136417592 @default.
- W4287736975 cites W2140124881 @default.
- W4287736975 cites W2147140735 @default.
- W4287736975 cites W2153860431 @default.
- W4287736975 cites W2161994233 @default.
- W4287736975 cites W2193493665 @default.
- W4287736975 cites W2195783463 @default.
- W4287736975 cites W2280070832 @default.
- W4287736975 cites W2328375366 @default.
- W4287736975 cites W2438256301 @default.
- W4287736975 cites W2469213152 @default.
- W4287736975 cites W2522538146 @default.
- W4287736975 cites W2552297085 @default.
- W4287736975 cites W2565199748 @default.
- W4287736975 cites W2626606138 @default.
- W4287736975 cites W2671308999 @default.
- W4287736975 cites W2723723801 @default.
- W4287736975 cites W2758932859 @default.
- W4287736975 cites W2793368865 @default.
- W4287736975 cites W2818417770 @default.
- W4287736975 cites W2895486342 @default.
- W4287736975 cites W2903167678 @default.
- W4287736975 cites W2906199739 @default.
- W4287736975 cites W2910199421 @default.
- W4287736975 cites W2922520125 @default.
- W4287736975 cites W2924359406 @default.
- W4287736975 cites W2949830473 @default.
- W4287736975 cites W2951079876 @default.
- W4287736975 cites W2952596949 @default.
- W4287736975 cites W2962468907 @default.
- W4287736975 cites W2975820925 @default.
- W4287736975 cites W2977829647 @default.
- W4287736975 cites W2989971106 @default.
- W4287736975 cites W3013837707 @default.
- W4287736975 cites W3024821462 @default.
- W4287736975 cites W3029661147 @default.
- W4287736975 cites W3045156259 @default.
- W4287736975 cites W3046366876 @default.
- W4287736975 cites W3081882476 @default.
- W4287736975 cites W3082720984 @default.
- W4287736975 cites W3084331777 @default.
- W4287736975 cites W3100828003 @default.
- W4287736975 cites W3125247928 @default.
- W4287736975 cites W3126252419 @default.
- W4287736975 cites W3127125943 @default.
- W4287736975 cites W3133698477 @default.
- W4287736975 cites W3152758353 @default.
- W4287736975 cites W3200659269 @default.
- W4287736975 cites W3216923594 @default.
- W4287736975 cites W4206175800 @default.
- W4287736975 cites W4212982350 @default.
- W4287736975 cites W4224255685 @default.
- W4287736975 cites W4229015963 @default.
- W4287736975 cites W4231061105 @default.
- W4287736975 cites W4254405378 @default.
- W4287736975 cites W4280523897 @default.
- W4287736975 doi "https://doi.org/10.1101/2022.05.06.490973" @default.
- W4287736975 hasPublicationYear "2022" @default.
- W4287736975 type Work @default.
- W4287736975 citedByCount "9" @default.
- W4287736975 countsByYear W42877369752022 @default.
- W4287736975 countsByYear W42877369752023 @default.
- W4287736975 crossrefType "posted-content" @default.
- W4287736975 hasAuthorship W4287736975A5003885949 @default.
- W4287736975 hasAuthorship W4287736975A5006553079 @default.
- W4287736975 hasAuthorship W4287736975A5026013829 @default.
- W4287736975 hasAuthorship W4287736975A5062614876 @default.
- W4287736975 hasAuthorship W4287736975A5089733345 @default.
- W4287736975 hasBestOaLocation W42877369751 @default.
- W4287736975 hasConcept C104317684 @default.
- W4287736975 hasConcept C105083479 @default.
- W4287736975 hasConcept C106934330 @default.
- W4287736975 hasConcept C130981225 @default.
- W4287736975 hasConcept C144024400 @default.
- W4287736975 hasConcept C149923435 @default.