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- W4287763191 abstract "We analyze oscillatory instabilities for a coupled PDE-ODE system modeling the communication between localized spatially segregated dynamically active signaling compartments that are coupled through a passive extracellular bulk diffusion field in a bounded 2-D domain. Each signaling compartment is assumed to secrete a chemical into the extracellular medium (bulk region) and it can also sense the concentration of this chemical in the region around its boundary. This feedback from the bulk region, resulting from the entire collection of cells, in turn modifies the intracellular dynamics within each cell. In the limit where the signaling compartments are circular disks with a small common radius $epsilon ll 1$ and where the bulk diffusivity is asymptotically large, a matched asymptotic analysis is used to reduce the dimensionless PDE-ODE system into a nonlinear ODE system with global coupling. For Sel'kov reaction kinetics, this ODE system for the intracellular dynamics and the spatial average of the bulk diffusion field is then used to investigate oscillatory instabilities in the dynamics of the cells that are triggered due to the global coupling. In particular, numerical bifurcation software on the ODEs is used to study the overall effect of coupling defective cells (cells that behave differently from the remaining cells) to a group of identical cells. Moreover, when the number of cells is large, the Kuramoto order parameter is computed to predict the degree of phase synchronization of the intracellular dynamics. Quorum sensing behavior, characterized by the onset of collective behavior in the intracellular dynamics as the number of cells increases above a threshold, is also studied. Our analysis shows that the cell population density plays a dual role of triggering and then quenching synchronous oscillations in the intracellular dynamics." @default.
- W4287763191 created "2022-07-26" @default.
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- W4287763191 date "2020-06-05" @default.
- W4287763191 modified "2023-09-26" @default.
- W4287763191 title "Localized Signaling Compartments in 2-D Coupled by a Bulk Diffusion Field: Quorum Sensing and Synchronous Oscillations in the Well-Mixed Limit" @default.
- W4287763191 doi "https://doi.org/10.48550/arxiv.2006.03775" @default.
- W4287763191 hasPublicationYear "2020" @default.
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