FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4287831372> ?p ?o ?g. }

• W4287831372 endingPage "101564" @default.
• W4287831372 startingPage "101564" @default.
• W4287831372 abstract "Toll-like receptors (TLRs) have recently emerged as one of the potential targets for immune activation. Therefore, TLR agonists have gotten much attention in the immunotherapy field, and have been proven effective in activating antigen-presenting cells (e.g., dendritic cells) and extensively studied for immune adjuvants. However, the applications of TLR-activating nucleic acids are severely limited by their poor effectiveness and utilization in vivo. Herein, we rationally bioengineered the natural nanocage-like protein, human heavy chain ferritin (HFn), with a positively charged cavity to construct a series of HFn(+) mutants for the internal encapsulation of TLR-activating nucleic acids via electrostatic interaction. Through systematic screenings, we selected the optimal HFn(+) nanocarrier and identified its universal loading ability for different types of TLR-activating nucleic acids. Through in vitro and in vivo experiments, we found that HFn(+) nanocarrier has significantly improved the delivery efficiency of TLR-activating nucleic acids, achieving efficient cell uptake, specific lysosomal localization and enhanced immune activation. Moreover, by virtue of its cage-like spatial structure, TLR-activating nucleic acid loaded HFn(+) shows great potential in combination with the other existing immune strategies via externally modifying function modules. In this study, we conjugated photodynamic photosensitizer chlorin e6 (Ce6) on the external surface of the HFn(+) carrier as an immunogenic death (ICD) inducer. The results show that the HFn(+)-based all-in-one platform effectively synergized TLR agonist-mediated and ICD-mediated immune activation, as evidenced by inducing significantly systemic immune responses, antitumor abscopal effect, and anti-metastasis efficacy in vivo. In conclusion, this nanocage-based carrier is a convenient and universal vehicle to effectively deliver different TLR-activating nucleic acids in vivo and may serve as a novel strategy for the combination of antitumor immunotherapies." @default.
• W4287831372 created "2022-07-26" @default.
• W4287831372 creator A5016060445 @default.
• W4287831372 creator A5022974724 @default.
• W4287831372 creator A5023277894 @default.
• W4287831372 creator A5038939879 @default.
• W4287831372 creator A5044309014 @default.
• W4287831372 creator A5046102901 @default.
• W4287831372 creator A5051081481 @default.
• W4287831372 creator A5059641714 @default.
• W4287831372 date "2022-10-01" @default.
• W4287831372 modified "2023-10-16" @default.
• W4287831372 title "Constructing a nanocage-based universal carrier for delivering TLR-activating nucleic acids to enhance antitumor immunotherapy" @default.
• W4287831372 cites W124239641 @default.
• W4287831372 cites W1515466910 @default.
• W4287831372 cites W1599588446 @default.
• W4287831372 cites W1832918390 @default.
• W4287831372 cites W1909313221 @default.
• W4287831372 cites W1951507118 @default.
• W4287831372 cites W1965130745 @default.
• W4287831372 cites W1966386515 @default.
• W4287831372 cites W1969072247 @default.
• W4287831372 cites W1973687489 @default.
• W4287831372 cites W1984618863 @default.
• W4287831372 cites W1991910834 @default.
• W4287831372 cites W2005659834 @default.
• W4287831372 cites W2009834812 @default.
• W4287831372 cites W2014684238 @default.
• W4287831372 cites W2024256121 @default.
• W4287831372 cites W2025381786 @default.
• W4287831372 cites W2040503769 @default.
• W4287831372 cites W2046931618 @default.
• W4287831372 cites W2048056641 @default.
• W4287831372 cites W2049449151 @default.
• W4287831372 cites W2051452929 @default.
• W4287831372 cites W2054026810 @default.
• W4287831372 cites W2060420887 @default.
• W4287831372 cites W2067632426 @default.
• W4287831372 cites W2075338937 @default.
• W4287831372 cites W2083524314 @default.
• W4287831372 cites W2083922309 @default.
• W4287831372 cites W2087604357 @default.
• W4287831372 cites W2095472825 @default.
• W4287831372 cites W2114208662 @default.
• W4287831372 cites W2116564247 @default.
• W4287831372 cites W2117855155 @default.
• W4287831372 cites W2123662098 @default.
• W4287831372 cites W2129325343 @default.
• W4287831372 cites W2137714257 @default.
• W4287831372 cites W2146898483 @default.
• W4287831372 cites W2147603340 @default.
• W4287831372 cites W2150736048 @default.
• W4287831372 cites W2161242709 @default.
• W4287831372 cites W2299345466 @default.
• W4287831372 cites W2587714509 @default.
• W4287831372 cites W2717611831 @default.
• W4287831372 cites W2795569119 @default.
• W4287831372 cites W2945583619 @default.
• W4287831372 cites W2971579444 @default.
• W4287831372 cites W2981487371 @default.
• W4287831372 cites W2985879358 @default.
• W4287831372 cites W2989926088 @default.
• W4287831372 cites W3000930612 @default.
• W4287831372 cites W3005171791 @default.
• W4287831372 cites W3048788919 @default.
• W4287831372 cites W3091981841 @default.
• W4287831372 cites W3097547374 @default.
• W4287831372 cites W3122174179 @default.
• W4287831372 cites W3165868809 @default.
• W4287831372 cites W3171835979 @default.
• W4287831372 cites W3174686093 @default.
• W4287831372 cites W3196730242 @default.
• W4287831372 cites W3198244112 @default.
• W4287831372 cites W3211312289 @default.
• W4287831372 doi "https://doi.org/10.1016/j.nantod.2022.101564" @default.
• W4287831372 hasPublicationYear "2022" @default.
• W4287831372 type Work @default.
• W4287831372 citedByCount "9" @default.
• W4287831372 countsByYear W42878313722022 @default.
• W4287831372 countsByYear W42878313722023 @default.
• W4287831372 crossrefType "journal-article" @default.
• W4287831372 hasAuthorship W4287831372A5016060445 @default.
• W4287831372 hasAuthorship W4287831372A5022974724 @default.
• W4287831372 hasAuthorship W4287831372A5023277894 @default.
• W4287831372 hasAuthorship W4287831372A5038939879 @default.
• W4287831372 hasAuthorship W4287831372A5044309014 @default.
• W4287831372 hasAuthorship W4287831372A5046102901 @default.
• W4287831372 hasAuthorship W4287831372A5051081481 @default.
• W4287831372 hasAuthorship W4287831372A5059641714 @default.
• W4287831372 hasConcept C128355301 @default.
• W4287831372 hasConcept C136449434 @default.
• W4287831372 hasConcept C150903083 @default.
• W4287831372 hasConcept C161790260 @default.
• W4287831372 hasConcept C178790620 @default.
• W4287831372 hasConcept C18150654 @default.
• W4287831372 hasConcept C185592680 @default.
• W4287831372 hasConcept C203014093 @default.
• W4287831372 hasConcept C207001950 @default.

• next