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- W4287911478 abstract "The purpose of this experimental study was to evaluate the osteointegration of a bioactive 3D-cylindrical titanium-alloy implant (bone-graft substitute) for tibial shaft defect reconstruction.An experimental study was done in 7 mongrel dogs. Tibial shaft defect was repaired using an original titanium-alloy (Ti6Al4V) cellular cylindrical implant. with a bioactive layer of hydroxyapatite by anode microarc oxidation. Histological study (hematoxylin-eosin stain and immunohistological reaction using ostepontin polyclonal antibodies) and scanning electron microscopy (electron probe X-ray microanalysis for calcium and phosphorus saturation in the tissue matrix) were applied to assess bone tissue regeneration.Experimental study revealed osteoconduction starting from the endosteum of bone fragments adjacent to the bone defect and developed to the central part of the implant. In 4 weeks, graft osteointegration was achieved in all animals. Implant cells were filled with spongy bone tissue and the graft external surface was covered with a connective tissue structures similar to the periosteum ones.Cellular titanium bone-graft substitute with bioactive coatings placed into bone defect stimulates reparative osteogenesis and graft osteointegration." @default.
- W4287911478 created "2022-07-26" @default.
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- W4287911478 date "2020-01-01" @default.
- W4287911478 modified "2023-09-29" @default.
- W4287911478 title "Osteointegration technology in long bone defect reconstruction: experimental study." @default.
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- W4287911478 hasPublicationYear "2020" @default.
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