FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4287922327> ?p ?o ?g. }

• W4287922327 abstract "Abstract Cognitive-behavioural testing in preclinical models of Alzheimer’s disease has typically been limited to visuo-spatial memory tests and has failed to capture the broad scope of deficits patients also display in goal-directed action control. The current study addresses this gap by providing the first comprehensive investigation of how goal-directed actions are affected in a transgenic mouse model of Alzheimer’s disease. Specifically, we tested outcome devaluation performance – a popular test of goal-directed action – in male and female human amyloid precursor protein (hAPP)-J20 mice. Mice were first trained to press a left and right lever for unique pellet and sucrose outcomes respectively (counterbalanced) over four days. On test, mice were fed one of the two outcomes to reduce its value via sensory specific satiety and subsequently given a choice between levers. Goal-directed action was intact for 36-week-old wildtype mice of both sexes, because they responded more on the lever associated with the still-valued outcome than that associated with the devalued outcome (i.e. Valued > Devalued). Goal-directed action was impaired (Valued = Devalued) for J20 mice of both sexes, and for 52-week-old male mice regardless of genotype. Following an additional 4 days of lever press training (i.e., 8 days lever pressing in total), outcome devaluation was intact for all mice regardless of age or genotype. Immunohistochemical analysis revealed that increased microglial expression in the dorsal CA1 region of the hippocampus was associated with poorer outcome devaluation performance on initial tests, but not with tests performed after 8 days of lever pressing. Together, these data demonstrate that goal-directed action is transiently impaired in J20 mice of both sexes and in aging male mice regardless of genotype, and that this impairment is related to neuroinflammation in the dorsal CA1 region of the hippocampus." @default.
• W4287922327 created "2022-07-26" @default.
• W4287922327 creator A5003502131 @default.
• W4287922327 creator A5003611073 @default.
• W4287922327 creator A5008883629 @default.
• W4287922327 creator A5016517137 @default.
• W4287922327 creator A5018724439 @default.
• W4287922327 creator A5065888945 @default.
• W4287922327 creator A5067908014 @default.
• W4287922327 creator A5087840723 @default.
• W4287922327 date "2022-07-25" @default.
• W4287922327 modified "2023-09-27" @default.
• W4287922327 title "Goal-directed action is transiently impaired in an hAPP-J20 mouse model of Alzheimer’s disease, and in aging male mice regardless of genotype" @default.
• W4287922327 cites W1517751222 @default.
• W4287922327 cites W1584834830 @default.
• W4287922327 cites W1965921983 @default.
• W4287922327 cites W1971541898 @default.
• W4287922327 cites W1975401347 @default.
• W4287922327 cites W1977343782 @default.
• W4287922327 cites W1982150127 @default.
• W4287922327 cites W1991098137 @default.
• W4287922327 cites W1991457465 @default.
• W4287922327 cites W2002961865 @default.
• W4287922327 cites W2004852048 @default.
• W4287922327 cites W2021948296 @default.
• W4287922327 cites W2023732657 @default.
• W4287922327 cites W2032920422 @default.
• W4287922327 cites W2038120217 @default.
• W4287922327 cites W2050914944 @default.
• W4287922327 cites W2051212454 @default.
• W4287922327 cites W2053176712 @default.
• W4287922327 cites W2061257589 @default.
• W4287922327 cites W2072000472 @default.
• W4287922327 cites W2083022530 @default.
• W4287922327 cites W2095456987 @default.
• W4287922327 cites W2112337921 @default.
• W4287922327 cites W2119102767 @default.
• W4287922327 cites W2146249493 @default.
• W4287922327 cites W2163179762 @default.
• W4287922327 cites W2173749165 @default.
• W4287922327 cites W2314634699 @default.
• W4287922327 cites W2337608681 @default.
• W4287922327 cites W2557614148 @default.
• W4287922327 cites W2737900099 @default.
• W4287922327 cites W2763463024 @default.
• W4287922327 cites W2769095960 @default.
• W4287922327 cites W2792696402 @default.
• W4287922327 cites W2802162372 @default.
• W4287922327 cites W2889996858 @default.
• W4287922327 cites W2891569200 @default.
• W4287922327 cites W2892798362 @default.
• W4287922327 cites W2903294600 @default.
• W4287922327 cites W2951912635 @default.
• W4287922327 cites W2952201080 @default.
• W4287922327 cites W2954842119 @default.
• W4287922327 cites W2987960305 @default.
• W4287922327 cites W3048202137 @default.
• W4287922327 cites W3154805883 @default.
• W4287922327 cites W3157221698 @default.
• W4287922327 cites W3201129361 @default.
• W4287922327 cites W3211267063 @default.
• W4287922327 cites W3213358256 @default.
• W4287922327 doi "https://doi.org/10.1101/2022.07.25.501480" @default.
• W4287922327 hasPublicationYear "2022" @default.
• W4287922327 type Work @default.
• W4287922327 citedByCount "0" @default.
• W4287922327 crossrefType "posted-content" @default.
• W4287922327 hasAuthorship W4287922327A5003502131 @default.
• W4287922327 hasAuthorship W4287922327A5003611073 @default.
• W4287922327 hasAuthorship W4287922327A5008883629 @default.
• W4287922327 hasAuthorship W4287922327A5016517137 @default.
• W4287922327 hasAuthorship W4287922327A5018724439 @default.
• W4287922327 hasAuthorship W4287922327A5065888945 @default.
• W4287922327 hasAuthorship W4287922327A5067908014 @default.
• W4287922327 hasAuthorship W4287922327A5087840723 @default.
• W4287922327 hasBestOaLocation W42879223271 @default.
• W4287922327 hasConcept C102230213 @default.
• W4287922327 hasConcept C104317684 @default.
• W4287922327 hasConcept C107524782 @default.
• W4287922327 hasConcept C121332964 @default.
• W4287922327 hasConcept C126322002 @default.
• W4287922327 hasConcept C138496976 @default.
• W4287922327 hasConcept C141035611 @default.
• W4287922327 hasConcept C15744967 @default.
• W4287922327 hasConcept C169760540 @default.
• W4287922327 hasConcept C2779134260 @default.
• W4287922327 hasConcept C2780791683 @default.
• W4287922327 hasConcept C54355233 @default.
• W4287922327 hasConcept C62520636 @default.
• W4287922327 hasConcept C71924100 @default.
• W4287922327 hasConcept C86803240 @default.
• W4287922327 hasConceptScore W4287922327C102230213 @default.
• W4287922327 hasConceptScore W4287922327C104317684 @default.
• W4287922327 hasConceptScore W4287922327C107524782 @default.
• W4287922327 hasConceptScore W4287922327C121332964 @default.
• W4287922327 hasConceptScore W4287922327C126322002 @default.
• W4287922327 hasConceptScore W4287922327C138496976 @default.
• W4287922327 hasConceptScore W4287922327C141035611 @default.
• W4287922327 hasConceptScore W4287922327C15744967 @default.
• W4287922327 hasConceptScore W4287922327C169760540 @default.

• next