FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4287930277> ?p ?o ?g. }

• W4287930277 endingPage "203" @default.
• W4287930277 startingPage "203" @default.
• W4287930277 abstract "In traditional medicine, the maceration of seeds of Garcinia kola (GK) is used to treat various diseases including diabetes. In traditional pharmacopoeia, GK seeds are used to strengthen the immune system and as a stimulant and aphrodisiac.This study aimed to evaluate the antidiabetic free radical scavenging effects of the hydroalcoholic extract of GK seeds (HAEGS) in a dexamethasone-induced hyperglycemic (DexIH) rat model.This study was an interventional study.Here using in vivo model, we assessed some pharmacological properties of HAEGS in DexIH rat. Hypoglycemia, antihyperglycemia, spasmolytic and laxative activities were also evaluated in DexIH. In vitro study assessed antiradical activity. The HAEGS was obtained by decoction introducing 250 g with water-ethanol mixture (30:70). The plant extract was administered to the animals at doses of 50 (GK50) and 100 (GK100) mg/kg body weight. All animal experiments were in accordance with ARRIVE guidelines and were performed in accordance with the scientific procedures of UK Animals. Antiradical activity of GK was assessed in vitro by inhibition of the activity of 2,2-diphenyl-1-picrylhydrazyl.Statistical analysis was performed using GraphPad Prism 5.03 software, and P values less than 0.05 were considered statistically significant.At doses 50 and 100 mg/kg, GK significantly (P < 0.001) regulated DexIH after two weeks of treatment compared to the normoglycemic control and hyperglycemic rats. The extract at both doses significantly (P < 0.001) inhibited the spasmolytic activity in both normoglycemic and hyperglycemic rats compared to Imodium®. In rats DexIH rats, only dose 100 mg/kg significantly (P < 0.05) increased laxative effects when compared to the negative control. In vitro antiradical activity of GK revealed vitamin C-like antiradical activity.This study justifies the traditional use of GK seeds as an antidiabetic." @default.
• W4287930277 created "2022-07-26" @default.
• W4287930277 creator A5004845013 @default.
• W4287930277 creator A5013809943 @default.
• W4287930277 creator A5027614836 @default.
• W4287930277 creator A5033988414 @default.
• W4287930277 creator A5041418556 @default.
• W4287930277 creator A5044731022 @default.
• W4287930277 creator A5061435510 @default.
• W4287930277 creator A5063935612 @default.
• W4287930277 creator A5065770682 @default.
• W4287930277 date "2022-01-01" @default.
• W4287930277 modified "2023-10-16" @default.
• W4287930277 title "Antidiabetic and antiradical effects of Garcinia kola seeds in dexamethasone-induced hyperglycemic rats" @default.
• W4287930277 cites W1963928184 @default.
• W4287930277 cites W1983902158 @default.
• W4287930277 cites W1984243021 @default.
• W4287930277 cites W1989130597 @default.
• W4287930277 cites W1994650650 @default.
• W4287930277 cites W1999559168 @default.
• W4287930277 cites W2003418275 @default.
• W4287930277 cites W2006260980 @default.
• W4287930277 cites W2009089029 @default.
• W4287930277 cites W2011099920 @default.
• W4287930277 cites W2024212561 @default.
• W4287930277 cites W2047996813 @default.
• W4287930277 cites W2057903224 @default.
• W4287930277 cites W2059089565 @default.
• W4287930277 cites W2067333236 @default.
• W4287930277 cites W2072872152 @default.
• W4287930277 cites W2084368360 @default.
• W4287930277 cites W2102797065 @default.
• W4287930277 cites W2105695405 @default.
• W4287930277 cites W2126881686 @default.
• W4287930277 cites W2138121862 @default.
• W4287930277 cites W2153394357 @default.
• W4287930277 cites W2159398148 @default.
• W4287930277 cites W2169310017 @default.
• W4287930277 cites W2187261531 @default.
• W4287930277 cites W2615637571 @default.
• W4287930277 cites W2751684688 @default.
• W4287930277 cites W2893481526 @default.
• W4287930277 cites W2905380353 @default.
• W4287930277 cites W2910987008 @default.
• W4287930277 cites W3047879827 @default.
• W4287930277 cites W4205498776 @default.
• W4287930277 cites W4236357753 @default.
• W4287930277 doi "https://doi.org/10.4103/ijabmr.ijabmr_199_22" @default.
• W4287930277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36131856" @default.
• W4287930277 hasPublicationYear "2022" @default.
• W4287930277 type Work @default.
• W4287930277 citedByCount "1" @default.
• W4287930277 countsByYear W42879302772023 @default.
• W4287930277 crossrefType "journal-article" @default.
• W4287930277 hasAuthorship W4287930277A5004845013 @default.
• W4287930277 hasAuthorship W4287930277A5013809943 @default.
• W4287930277 hasAuthorship W4287930277A5027614836 @default.
• W4287930277 hasAuthorship W4287930277A5033988414 @default.
• W4287930277 hasAuthorship W4287930277A5041418556 @default.
• W4287930277 hasAuthorship W4287930277A5044731022 @default.
• W4287930277 hasAuthorship W4287930277A5061435510 @default.
• W4287930277 hasAuthorship W4287930277A5063935612 @default.
• W4287930277 hasAuthorship W4287930277A5065770682 @default.
• W4287930277 hasBestOaLocation W42879302772 @default.
• W4287930277 hasConcept C126322002 @default.
• W4287930277 hasConcept C134018914 @default.
• W4287930277 hasConcept C142724271 @default.
• W4287930277 hasConcept C150903083 @default.
• W4287930277 hasConcept C185592680 @default.
• W4287930277 hasConcept C190409667 @default.
• W4287930277 hasConcept C204787440 @default.
• W4287930277 hasConcept C207001950 @default.
• W4287930277 hasConcept C2777778793 @default.
• W4287930277 hasConcept C2778004101 @default.
• W4287930277 hasConcept C2778951191 @default.
• W4287930277 hasConcept C2780401358 @default.
• W4287930277 hasConcept C55493867 @default.
• W4287930277 hasConcept C555293320 @default.
• W4287930277 hasConcept C556039675 @default.
• W4287930277 hasConcept C71924100 @default.
• W4287930277 hasConcept C86803240 @default.
• W4287930277 hasConcept C98274493 @default.
• W4287930277 hasConceptScore W4287930277C126322002 @default.
• W4287930277 hasConceptScore W4287930277C134018914 @default.
• W4287930277 hasConceptScore W4287930277C142724271 @default.
• W4287930277 hasConceptScore W4287930277C150903083 @default.
• W4287930277 hasConceptScore W4287930277C185592680 @default.
• W4287930277 hasConceptScore W4287930277C190409667 @default.
• W4287930277 hasConceptScore W4287930277C204787440 @default.
• W4287930277 hasConceptScore W4287930277C207001950 @default.
• W4287930277 hasConceptScore W4287930277C2777778793 @default.
• W4287930277 hasConceptScore W4287930277C2778004101 @default.
• W4287930277 hasConceptScore W4287930277C2778951191 @default.
• W4287930277 hasConceptScore W4287930277C2780401358 @default.
• W4287930277 hasConceptScore W4287930277C55493867 @default.
• W4287930277 hasConceptScore W4287930277C555293320 @default.
• W4287930277 hasConceptScore W4287930277C556039675 @default.
• W4287930277 hasConceptScore W4287930277C71924100 @default.

• next