Matches in SemOpenAlex for { <https://semopenalex.org/work/W4287958437> ?p ?o ?g. }
- W4287958437 abstract "Abstract Hyperaldosteronism causes cardiovascular disease as well as hypomagnesemia. Mechanisms are ill-defined but dysregulation of TRPM7, a Mg 2+ -permeable channel/α-kinase, may be important. We examined the role of TRPM7 in aldosterone-dependent cardiovascular and renal injury by studying aldosterone-salt treated TRPM7-deficient (TRPM7 +/Δkinase ) mice. Plasma/tissue [Mg 2+ ] and TRPM7 phosphorylation were reduced in vehicle-treated TRPM7 +/Δkinase mice, effects recapitulated in aldosterone-salt-treated wild-type mice. Aldosterone-salt treatment exaggerated vascular dysfunction and amplified cardiovascular and renal fibrosis, with associated increased blood pressure in TRPM7 +/Δkinase mice. Tissue expression of Mg 2+ -regulated phosphatases (PPM1A, PTEN) was downregulated and phosphorylation of Smad3, ERK1/2, and Stat1 was upregulated in aldosterone-salt TRPM7-deficient mice. Aldosterone-induced phosphorylation of pro-fibrotic signaling was increased in TRPM7 +/Δkinase fibroblasts, effects ameliorated by Mg 2+ supplementation. TRPM7 deficiency amplifies aldosterone-salt-induced cardiovascular remodeling and damage. We identify TRPM7 downregulation and associated hypomagnesemia as putative molecular mechanisms underlying deleterious cardiovascular and renal effects of hyperaldosteronism." @default.
- W4287958437 created "2022-07-26" @default.
- W4287958437 creator A5013040843 @default.
- W4287958437 creator A5017512470 @default.
- W4287958437 creator A5031996384 @default.
- W4287958437 creator A5042362916 @default.
- W4287958437 creator A5049888006 @default.
- W4287958437 creator A5057798596 @default.
- W4287958437 creator A5064294168 @default.
- W4287958437 creator A5065770496 @default.
- W4287958437 creator A5065854689 @default.
- W4287958437 creator A5066413469 @default.
- W4287958437 creator A5070531416 @default.
- W4287958437 creator A5075006772 @default.
- W4287958437 creator A5082482052 @default.
- W4287958437 creator A5084716908 @default.
- W4287958437 creator A5086186691 @default.
- W4287958437 creator A5086285174 @default.
- W4287958437 date "2022-07-26" @default.
- W4287958437 modified "2023-10-18" @default.
- W4287958437 title "TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt" @default.
- W4287958437 cites W1967217627 @default.
- W4287958437 cites W1972370037 @default.
- W4287958437 cites W1975298390 @default.
- W4287958437 cites W1979764452 @default.
- W4287958437 cites W1990190218 @default.
- W4287958437 cites W1997815426 @default.
- W4287958437 cites W1998700853 @default.
- W4287958437 cites W2012568931 @default.
- W4287958437 cites W2016855276 @default.
- W4287958437 cites W2022021686 @default.
- W4287958437 cites W2025642985 @default.
- W4287958437 cites W2027759762 @default.
- W4287958437 cites W2029265742 @default.
- W4287958437 cites W2034779933 @default.
- W4287958437 cites W2036085730 @default.
- W4287958437 cites W2055961155 @default.
- W4287958437 cites W2067956701 @default.
- W4287958437 cites W2069481218 @default.
- W4287958437 cites W2078025284 @default.
- W4287958437 cites W2088838508 @default.
- W4287958437 cites W2094002123 @default.
- W4287958437 cites W2100509778 @default.
- W4287958437 cites W2104824409 @default.
- W4287958437 cites W2107277218 @default.
- W4287958437 cites W2109509624 @default.
- W4287958437 cites W2111273769 @default.
- W4287958437 cites W2113923747 @default.
- W4287958437 cites W2117062067 @default.
- W4287958437 cites W2141402302 @default.
- W4287958437 cites W2151512622 @default.
- W4287958437 cites W2155376439 @default.
- W4287958437 cites W2166073081 @default.
- W4287958437 cites W2192080449 @default.
- W4287958437 cites W2288445429 @default.
- W4287958437 cites W2313039228 @default.
- W4287958437 cites W2338215984 @default.
- W4287958437 cites W2412782047 @default.
- W4287958437 cites W2595332104 @default.
- W4287958437 cites W2607031541 @default.
- W4287958437 cites W2751435797 @default.
- W4287958437 cites W2763231015 @default.
- W4287958437 cites W2766220517 @default.
- W4287958437 cites W2767214141 @default.
- W4287958437 cites W2768099675 @default.
- W4287958437 cites W2785649171 @default.
- W4287958437 cites W2861116898 @default.
- W4287958437 cites W2890860459 @default.
- W4287958437 cites W2890914388 @default.
- W4287958437 cites W2900070070 @default.
- W4287958437 cites W2911908266 @default.
- W4287958437 cites W2948410106 @default.
- W4287958437 cites W2955332689 @default.
- W4287958437 cites W2963854128 @default.
- W4287958437 cites W2972394242 @default.
- W4287958437 cites W2978576320 @default.
- W4287958437 cites W2989683811 @default.
- W4287958437 cites W2997836505 @default.
- W4287958437 cites W3043135743 @default.
- W4287958437 cites W3183153307 @default.
- W4287958437 doi "https://doi.org/10.1038/s42003-022-03715-z" @default.
- W4287958437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35882956" @default.
- W4287958437 hasPublicationYear "2022" @default.
- W4287958437 type Work @default.
- W4287958437 citedByCount "1" @default.
- W4287958437 countsByYear W42879584372023 @default.
- W4287958437 crossrefType "journal-article" @default.
- W4287958437 hasAuthorship W4287958437A5013040843 @default.
- W4287958437 hasAuthorship W4287958437A5017512470 @default.
- W4287958437 hasAuthorship W4287958437A5031996384 @default.
- W4287958437 hasAuthorship W4287958437A5042362916 @default.
- W4287958437 hasAuthorship W4287958437A5049888006 @default.
- W4287958437 hasAuthorship W4287958437A5057798596 @default.
- W4287958437 hasAuthorship W4287958437A5064294168 @default.
- W4287958437 hasAuthorship W4287958437A5065770496 @default.
- W4287958437 hasAuthorship W4287958437A5065854689 @default.
- W4287958437 hasAuthorship W4287958437A5066413469 @default.
- W4287958437 hasAuthorship W4287958437A5070531416 @default.
- W4287958437 hasAuthorship W4287958437A5075006772 @default.
- W4287958437 hasAuthorship W4287958437A5082482052 @default.