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- W4287958488 abstract "A new acyclic bismuth complex (Bi-edtabz) was synthesized from a mixture of solutions of the ligand (EDTA-based phenylene) and bismuth under acidic conditions. Its anti-virulence properties were evaluated against Escherichia coli O157: H7, Listeria monocytogenes , Pseudomonas aeruginosa , Salmonella enterica sub. enterica serovar Typhimurium and Staphylococcus aureus . The bismuth complex was characterized by NMR, UV-Vis, FTIR, ESI/MS and TG. Furthermore, Bi-edtabz complex at 0.25–1 mM presented better antibiofilm properties against E. coli O157: H7 and S. aureus with values of biomass reduction of 30.1–57.1% and 37.8–55.5%, respectively, compared with the ligand edtabz. While biofilm formation of L. monocytogenes , P. aeruginosa and Salmonella Typhimurium was most impaired by edtabz (biomass reduction of 66.1–100%, 66.4–88.0% and 50.9–67.1%), respectively. Additionally, Bi-edtabz inhibited the swimming motility of E. coli O157: H7 (12.5%) and colony spread of S. aureus (47.2%) at 1 mM and inhibited violacein production, a quorum-sensing related pigment of the biosensor strain Chromobacterium violaceum . Hence, edtabz and the Bi-edtabz complex can be used as novel anti-virulence agents against pathogenic bacteria." @default.
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- W4287958488 date "2022-07-26" @default.
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- W4287958488 title "Synthesis and characterization of bismuth(III) complex with an EDTA-based phenylene ligand and its potential as anti-virulence agent" @default.
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- W4287958488 doi "https://doi.org/10.7717/peerj-ichem.4" @default.
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