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- W4287958752 abstract "Bacterial pathogens have a critical impact on aquaculture, a sector that accounts for half of the human fish consumption. Flavobacterium psychrophilum (phylum Bacteroidetes) is responsible for bacterial cold-water disease in salmonids worldwide. The molecular factors involved in host invasion, colonization and haemorrhagic septicaemia are mostly unknown. In this study, we identified two new TonB-dependent receptors, HfpR and BfpR, that are required for adaptation to iron conditions encountered during infection and for virulence in rainbow trout. Transcriptional analyses revealed that their expression is tightly controlled and upregulated under specific iron sources and concentrations. Characterization of deletion mutants showed that they act without redundancy: BfpR is required for optimal growth in the presence of high haemoglobin level, while HfpR confers the capacity to acquire nutrient iron from haem or haemoglobin under iron scarcity. The gene hfpY, co-transcribed with hfpR, encodes a protein related to the HmuY family. We demonstrated that HfpY binds haem and contributes significantly to host colonization and disease severity. Overall, these results are consistent with a model in which both BfpR and Hfp systems promote haem uptake and respond to distinct signals to adapt iron acquisition to the different stages of pathogenesis. Our findings give insight into the molecular basis of pathogenicity of a serious pathogen belonging to the understudied family Flavobacteriaceae and point to the newly identified haem receptors as promising targets for antibacterial development." @default.
- W4287958752 created "2022-07-26" @default.
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- W4287958752 date "2022-07-26" @default.
- W4287958752 modified "2023-10-12" @default.
- W4287958752 title "Two functionally distinct heme/iron transport systems are virulence determinants of the fish pathogen <i>Flavobacterium psychrophilum</i>" @default.
- W4287958752 cites W1488951193 @default.
- W4287958752 cites W1857720837 @default.
- W4287958752 cites W1911403670 @default.
- W4287958752 cites W1965874164 @default.
- W4287958752 cites W1970936137 @default.
- W4287958752 cites W1977698433 @default.
- W4287958752 cites W1982530307 @default.
- W4287958752 cites W1989292483 @default.
- W4287958752 cites W1997814738 @default.
- W4287958752 cites W2003284609 @default.
- W4287958752 cites W2014723793 @default.
- W4287958752 cites W2023690137 @default.
- W4287958752 cites W2041089815 @default.
- W4287958752 cites W2044464933 @default.
- W4287958752 cites W2052554399 @default.
- W4287958752 cites W2052868652 @default.
- W4287958752 cites W2059787437 @default.
- W4287958752 cites W2060976020 @default.
- W4287958752 cites W2061507732 @default.
- W4287958752 cites W2065481994 @default.
- W4287958752 cites W2068702327 @default.
- W4287958752 cites W2069666755 @default.
- W4287958752 cites W2069761280 @default.
- W4287958752 cites W2077124327 @default.
- W4287958752 cites W2081978527 @default.
- W4287958752 cites W2083660844 @default.
- W4287958752 cites W2083859448 @default.
- W4287958752 cites W2095332593 @default.
- W4287958752 cites W2098722731 @default.
- W4287958752 cites W2106411441 @default.
- W4287958752 cites W2108192886 @default.
- W4287958752 cites W2121491059 @default.
- W4287958752 cites W2124974130 @default.
- W4287958752 cites W2125018422 @default.
- W4287958752 cites W2130060890 @default.
- W4287958752 cites W2130630244 @default.
- W4287958752 cites W2139040250 @default.
- W4287958752 cites W2142803745 @default.
- W4287958752 cites W2146108913 @default.
- W4287958752 cites W2168662799 @default.
- W4287958752 cites W2429359443 @default.
- W4287958752 cites W2460649015 @default.
- W4287958752 cites W2559088283 @default.
- W4287958752 cites W2583724058 @default.
- W4287958752 cites W2586539048 @default.
- W4287958752 cites W2588235721 @default.
- W4287958752 cites W2589359691 @default.
- W4287958752 cites W2597506409 @default.
- W4287958752 cites W2601571567 @default.
- W4287958752 cites W2755380627 @default.
- W4287958752 cites W2766504510 @default.
- W4287958752 cites W2794351656 @default.
- W4287958752 cites W2894413552 @default.
- W4287958752 cites W2907305238 @default.
- W4287958752 cites W2908911594 @default.
- W4287958752 cites W2910019178 @default.
- W4287958752 cites W2944544186 @default.
- W4287958752 cites W2956816640 @default.
- W4287958752 cites W2960445080 @default.
- W4287958752 cites W2964389869 @default.
- W4287958752 cites W2980019063 @default.
- W4287958752 cites W2997532854 @default.
- W4287958752 cites W2998466924 @default.
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- W4287958752 cites W3036243645 @default.
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- W4287958752 cites W3120964251 @default.
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- W4287958752 cites W3160922946 @default.
- W4287958752 cites W3164586072 @default.
- W4287958752 cites W3181427768 @default.
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- W4287958752 doi "https://doi.org/10.1080/21505594.2022.2101197" @default.
- W4287958752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35880611" @default.
- W4287958752 hasPublicationYear "2022" @default.
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