Matches in SemOpenAlex for { <https://semopenalex.org/work/W4287960605> ?p ?o ?g. }
- W4287960605 abstract "Cell migration requires establishment and maintenance of directional polarity, which in turn requires spatial heterogeneity in the regulation of protrusion, retraction, and adhesion. Thus, the signaling proteins that regulate these various structural processes must also be distinctly regulated in subcellular space. Protein Kinase A (PKA) is a ubiquitous serine/threonine kinase involved in innumerable cellular processes. In the context of cell migration, it has a paradoxical role in that global inhibition or activation of PKA inhibits migration. It follows, then, that the subcellular regulation of PKA is key to bringing its proper permissive and restrictive functions to the correct parts of the cell. Proper subcellular regulation of PKA controls not only when and where it is active but also specifies the targets for that activity, allowing the cell to use a single, promiscuous kinase to exert distinct functions within different subcellular niches to facilitate cell movement. In this way, understanding PKA signaling in migration is a study in context and in the elegant coordination of distinct functions of a single protein in a complex cellular process." @default.
- W4287960605 created "2022-07-26" @default.
- W4287960605 creator A5037781469 @default.
- W4287960605 creator A5054404638 @default.
- W4287960605 date "2022-07-22" @default.
- W4287960605 modified "2023-10-10" @default.
- W4287960605 title "Protein Kinase A in cellular migration—Niche signaling of a ubiquitous kinase" @default.
- W4287960605 cites W1236053900 @default.
- W4287960605 cites W1485823898 @default.
- W4287960605 cites W1487918137 @default.
- W4287960605 cites W1488759788 @default.
- W4287960605 cites W1496438529 @default.
- W4287960605 cites W1511836437 @default.
- W4287960605 cites W1559994288 @default.
- W4287960605 cites W1575134115 @default.
- W4287960605 cites W1739859666 @default.
- W4287960605 cites W1811064827 @default.
- W4287960605 cites W1830840014 @default.
- W4287960605 cites W1883732752 @default.
- W4287960605 cites W1927046000 @default.
- W4287960605 cites W1945644473 @default.
- W4287960605 cites W1956175627 @default.
- W4287960605 cites W1969583788 @default.
- W4287960605 cites W1970460837 @default.
- W4287960605 cites W1977304717 @default.
- W4287960605 cites W1977874249 @default.
- W4287960605 cites W1977984619 @default.
- W4287960605 cites W1983421902 @default.
- W4287960605 cites W1984212762 @default.
- W4287960605 cites W1984242582 @default.
- W4287960605 cites W1987380845 @default.
- W4287960605 cites W1988020128 @default.
- W4287960605 cites W1988194926 @default.
- W4287960605 cites W1988787904 @default.
- W4287960605 cites W1988914933 @default.
- W4287960605 cites W1989168851 @default.
- W4287960605 cites W1990397681 @default.
- W4287960605 cites W1990990311 @default.
- W4287960605 cites W1994825452 @default.
- W4287960605 cites W1995140110 @default.
- W4287960605 cites W1997882821 @default.
- W4287960605 cites W1998709931 @default.
- W4287960605 cites W2000104695 @default.
- W4287960605 cites W2000131429 @default.
- W4287960605 cites W2002337842 @default.
- W4287960605 cites W2004293544 @default.
- W4287960605 cites W2007660746 @default.
- W4287960605 cites W2007859522 @default.
- W4287960605 cites W2010928352 @default.
- W4287960605 cites W2011231091 @default.
- W4287960605 cites W2011719452 @default.
- W4287960605 cites W2012455479 @default.
- W4287960605 cites W2013424896 @default.
- W4287960605 cites W2015679500 @default.
- W4287960605 cites W2020012150 @default.
- W4287960605 cites W2021286146 @default.
- W4287960605 cites W2023396177 @default.
- W4287960605 cites W2026260372 @default.
- W4287960605 cites W2027282106 @default.
- W4287960605 cites W2029511829 @default.
- W4287960605 cites W2032842750 @default.
- W4287960605 cites W2034217662 @default.
- W4287960605 cites W2034467929 @default.
- W4287960605 cites W2034598341 @default.
- W4287960605 cites W2035106025 @default.
- W4287960605 cites W2035697399 @default.
- W4287960605 cites W2035870242 @default.
- W4287960605 cites W2036145275 @default.
- W4287960605 cites W2036857715 @default.
- W4287960605 cites W2038634187 @default.
- W4287960605 cites W2039522435 @default.
- W4287960605 cites W2044191997 @default.
- W4287960605 cites W2044423100 @default.
- W4287960605 cites W2044697616 @default.
- W4287960605 cites W2044895919 @default.
- W4287960605 cites W2045122061 @default.
- W4287960605 cites W2046364610 @default.
- W4287960605 cites W2047026162 @default.
- W4287960605 cites W2049751711 @default.
- W4287960605 cites W2051162608 @default.
- W4287960605 cites W2051619902 @default.
- W4287960605 cites W2052750950 @default.
- W4287960605 cites W2053144857 @default.
- W4287960605 cites W2054088330 @default.
- W4287960605 cites W2054996246 @default.
- W4287960605 cites W2055737181 @default.
- W4287960605 cites W2056290784 @default.
- W4287960605 cites W2056293240 @default.
- W4287960605 cites W2057415995 @default.
- W4287960605 cites W2060071257 @default.
- W4287960605 cites W2062606765 @default.
- W4287960605 cites W2062682840 @default.
- W4287960605 cites W2063220206 @default.
- W4287960605 cites W2063227306 @default.
- W4287960605 cites W2064965146 @default.
- W4287960605 cites W2066035722 @default.
- W4287960605 cites W2066228546 @default.
- W4287960605 cites W2068879726 @default.
- W4287960605 cites W2075988095 @default.
- W4287960605 cites W2076770108 @default.