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• W4287988307 abstract "Cirrhosis represents the final stage of any chronic liver disease. Some studies have demonstrated that intestinal microbiota can be responsible for some cirrhosis-related complications due to alterations in this system. In fact, its composition is different from that of healthy people, because there is a lower bacterial diversity with an increase in Gram-negatives and species of oral origin and shortage of native and beneficial families. Lactulose is a non-absorbable disaccharide widely used in clinical practice among cirrhotic patients which can modify intestinal microbiota. In particular, it represents the standard-of-care for hepatic encephalopathy (HE) treatment due to its cathartic effect and its ability to acidify the intestinal content. These properties are fundamental for the reduction of blood ammonium level, considered a key element in the pathogenesis of HE, through different mechanisms, such as the laxative effect, the ammonium ionization, the reduction of intestinal ammonium production, and finally the beneficial effect on intestinal microbiota. Several studies have demonstrated the role of this substance in the treatment of acute episodes of HE, secondary prophylaxis of HE, and treatment of minimal HE (MHE). However, some concern exists about the evaluation of the target to be reached, which up to now has been based on number of daily evacuations, and the indication for MHE treatment." @default.
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• W4287988307 date "2022-01-01" @default.
• W4287988307 modified "2023-10-14" @default.
• W4287988307 title "Lactulose in Liver Cirrhosis" @default.
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• W4287988307 doi "https://doi.org/10.1007/978-981-19-2615-0_14" @default.
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