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• W4288010147 abstract "T cell-based therapies have been widely explored for the treatment of cancer and chronic infection, but B cell-based therapies have remained largely unexplored. To study the effect of B cell therapy, we adoptively transferred virus-specific B cells into mice that were chronically infected with lymphocytic choriomeningitis virus (LCMV). Adoptive transfer of virus-specific B cells resulted in increase in antibody titers and reduction of viral loads. Importantly, the efficacy of B cell therapy was partly dependent on antibody effector functions, and was improved by co-transferring virus-specific CD4 T cells. These findings provide a proof-of-concept that adoptive B cell therapy can be effective for the treatment of chronic infections, but provision of virus-specific CD4 T cells may be critical for optimal virus neutralization." @default.
• W4288010147 created "2022-07-26" @default.
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• W4288010147 date "2022-07-26" @default.
• W4288010147 modified "2023-10-01" @default.
• W4288010147 title "Adoptive B cell therapy for chronic viral infection" @default.
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• W4288010147 doi "https://doi.org/10.3389/fimmu.2022.908707" @default.
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