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• W4288032498 abstract "Inferior bone-tissue regeneration, rapid tumor recurrence, and severe bacterial infection are the dominating challenges of osteosarcoma resection, which result in the failure of surgical intervention, and even amputation in serious circumstances. Herein, the multifunctional scaffolds (termed as ZCBS) are elaborately designed by in-situ integration of two-dimensional (2D) cocrystals with bioactive-glass scaffolds (BS) for significant osteosarcoma ablation, bacterial sterilization, and neo-bone regeneration. The efficient charge transfer between electron donor (zinc (II) tetraphenylporphyrin, ZnTPP) and acceptor (fullerene, C 60 ) molecules of 2D cocrystals facilitates ZCBS with prominent photothermal-conversion performance for osteosarcoma elimination and bacterial eradication. Meanwhile, the gradual release of C 60 and Zn 2+ is beneficial to the reinforced antibacterial capability of ZCBS. Furthermore, the macropore structures and progressive release of Zn 2+ , Ca 2+ , and PO 4 3- endow ZCBS with excellent osteogenic performance in promoting bone-tissue regeneration. Collectively, the engineered ZCBS bioscaffolds feature intrinsically multifunctional properties including antitumor, antibacterial, and osteogenic bioactivities, which support ZCBS for efficient osteosarcoma eradication, antibacterial treatment, and bone-tissue regeneration both in vitro and in vivo . Therefore, the developed “cocrystal engineering” strategy towards ZCBS with multifunctional bioactivities offer a competitive approach for osteosarcoma- and bacterial infection-induced bone regeneration. • Engineering multifunctional bioimplant by accurate regulation of the charge-transfer degree of cocrystals. • Prominent photothermal performance of 2D cocrystals enabled osteosarcoma elimination and bacterial eradication. • Macropore structures and progressive release of Zn 2+ , Ca 2+ , and PO 4 3- promoted bone-tissue regeneration." @default.
• W4288032498 created "2022-07-27" @default.
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• W4288032498 date "2022-10-01" @default.
• W4288032498 modified "2023-09-26" @default.
• W4288032498 title "Charge transfer of ZnTPP/C60 cocrystal-hybridized bioimplants satisfies osteosarcoma eradication with antitumoral, antibacterial and osteogenic performances" @default.
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• W4288032498 doi "https://doi.org/10.1016/j.nantod.2022.101562" @default.
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