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- W4288033410 abstract "Relapsed or refractory T acute lymphoblastic leukemia (T-ALL) still carries poor prognosis. Aiming to improve outcomes, the therapeutic potential of an anti-CCR9 monoclonal antibody (mAb 92R), targeting the human chemokine-receptor CCR9 is analyzed on orthotopic xenotransplants. 92R mAb treatment of mice carrying human CCR9 + T-ALL cell lines or primary T cell leukemias inhibits tumor growth and increases survival. The therapeutic effects of 92R are specific and synergize with chemotherapeutic agents increasing survival. Furthermore, 92R decreases size of non-hematopoietic tumors with a forced CCR9 expression and of solid tumors generated by the pancreatic adenocarcinoma cell line AsPC-1. In addition, a humanized version of 92R mAb (Srb1) is also able to inhibit growth of CCR9 + T-ALL tumor cells in vivo , increasing survival 2.66-fold. Finally, 92R mAb prevents liver accumulation of infiltrates and reduces tumor cell numbers in already formed infiltrates. Thus, the humanized version of 92R mAb (Srb1), displays therapeutic potential for CCR9 + tumor treatment and might represent one of the first therapeutic antibodies for precision medicine on T-ALL patients." @default.
- W4288033410 created "2022-07-27" @default.
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- W4288033410 date "2022-07-27" @default.
- W4288033410 modified "2023-10-16" @default.
- W4288033410 title "Therapeutic potential of an anti-CCR9 mAb evidenced in xenografts of human CCR9+ tumors" @default.
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- W4288033410 doi "https://doi.org/10.3389/fimmu.2022.825635" @default.
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