FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288033440> ?p ?o ?g. }

• W4288033440 abstract "Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are peptide hormones and growth factors. A major pathological feature of both Alzheimer’s dis-ease (AD) and Parkinson’s disease (PD) is the loss of synaptic transmission in the cortex in AD and the loss of dopaminergic synapses in the nigra-striatal dopaminergic projection. Several studies demonstrate that GLP-1 and GIP receptor agonists protect synapses and synaptic transmission from the toxic events that underlie AD and PD. In a range of AD animal models, treatment with GLP-1, GIP, or dual-GLP-1/GIP receptor agonists effectively protected cognition, synaptic trans-mission, long-term potentiation (LTP), and prevented the loss of synapses and neurons. In PD models, dopaminergic production resumed and synapses became functional again. Importantly, the GLP-1 receptor agonists exendin-4 and liraglutide have shown good protective effects in clinical trials in AD and PD patients. Studies show that growth factors and peptide drugs that can cross the blood–brain barrier (BBB) better are more potent than those that do not cross the BBB. We therefore developed dual-GLP-1/GIP receptor agonists that can cross the BBB at an enhanced rate and showed superior protective properties on synapses in animal models of AD and PD." @default.
• W4288033440 created "2022-07-27" @default.
• W4288033440 creator A5082707086 @default.
• W4288033440 date "2022-07-27" @default.
• W4288033440 modified "2023-10-05" @default.
• W4288033440 title "Glucagon-like peptide 1 and glucose-dependent insulinotropic peptide hormones and novel receptor agonists protect synapses in Alzheimer’s and Parkinson’s diseases" @default.
• W4288033440 cites W1012070930 @default.
• W4288033440 cites W1029387585 @default.
• W4288033440 cites W1525058897 @default.
• W4288033440 cites W1539187429 @default.
• W4288033440 cites W1795219500 @default.
• W4288033440 cites W1965978398 @default.
• W4288033440 cites W1966591940 @default.
• W4288033440 cites W1969800514 @default.
• W4288033440 cites W1971402768 @default.
• W4288033440 cites W1975774284 @default.
• W4288033440 cites W1976656679 @default.
• W4288033440 cites W1985349796 @default.
• W4288033440 cites W1988607716 @default.
• W4288033440 cites W1988937009 @default.
• W4288033440 cites W1991545746 @default.
• W4288033440 cites W1991775339 @default.
• W4288033440 cites W1996164493 @default.
• W4288033440 cites W1996893328 @default.
• W4288033440 cites W2001808016 @default.
• W4288033440 cites W2006376003 @default.
• W4288033440 cites W2009090653 @default.
• W4288033440 cites W2015739629 @default.
• W4288033440 cites W2016932677 @default.
• W4288033440 cites W2020486984 @default.
• W4288033440 cites W2025406583 @default.
• W4288033440 cites W2025811936 @default.
• W4288033440 cites W2030198351 @default.
• W4288033440 cites W2030270894 @default.
• W4288033440 cites W2030370891 @default.
• W4288033440 cites W2034930763 @default.
• W4288033440 cites W2042613656 @default.
• W4288033440 cites W2050581000 @default.
• W4288033440 cites W2054810445 @default.
• W4288033440 cites W2055499860 @default.
• W4288033440 cites W2056442085 @default.
• W4288033440 cites W2057410639 @default.
• W4288033440 cites W2060170946 @default.
• W4288033440 cites W2065789765 @default.
• W4288033440 cites W2066098514 @default.
• W4288033440 cites W2067732699 @default.
• W4288033440 cites W2068599677 @default.
• W4288033440 cites W2071199012 @default.
• W4288033440 cites W2071610467 @default.
• W4288033440 cites W2076140273 @default.
• W4288033440 cites W2079158266 @default.
• W4288033440 cites W2084071446 @default.
• W4288033440 cites W2084948079 @default.
• W4288033440 cites W2087787276 @default.
• W4288033440 cites W2088318694 @default.
• W4288033440 cites W2093534363 @default.
• W4288033440 cites W2093936360 @default.
• W4288033440 cites W2094958540 @default.
• W4288033440 cites W2097903441 @default.
• W4288033440 cites W2102200779 @default.
• W4288033440 cites W2111749961 @default.
• W4288033440 cites W2115030211 @default.
• W4288033440 cites W2115778460 @default.
• W4288033440 cites W2121398324 @default.
• W4288033440 cites W2123030262 @default.
• W4288033440 cites W2123319002 @default.
• W4288033440 cites W2127112728 @default.
• W4288033440 cites W2132774188 @default.
• W4288033440 cites W2149717292 @default.
• W4288033440 cites W2149917767 @default.
• W4288033440 cites W2154236525 @default.
• W4288033440 cites W2171732130 @default.
• W4288033440 cites W2199406275 @default.
• W4288033440 cites W2211963426 @default.
• W4288033440 cites W2300981798 @default.
• W4288033440 cites W2302402305 @default.
• W4288033440 cites W2317095451 @default.
• W4288033440 cites W2331605285 @default.
• W4288033440 cites W2342553225 @default.
• W4288033440 cites W2468864843 @default.
• W4288033440 cites W2589420593 @default.
• W4288033440 cites W2599792256 @default.
• W4288033440 cites W2601336399 @default.
• W4288033440 cites W2614847871 @default.
• W4288033440 cites W2728605505 @default.
• W4288033440 cites W2744843428 @default.
• W4288033440 cites W2756066122 @default.
• W4288033440 cites W2785903681 @default.
• W4288033440 cites W2791252329 @default.
• W4288033440 cites W2792638657 @default.
• W4288033440 cites W2793501551 @default.
• W4288033440 cites W2807256450 @default.
• W4288033440 cites W2887342138 @default.
• W4288033440 cites W2893305982 @default.
• W4288033440 cites W2908881986 @default.
• W4288033440 cites W2913950552 @default.
• W4288033440 cites W2916149712 @default.
• W4288033440 cites W2920903885 @default.
• W4288033440 cites W2924479779 @default.
• W4288033440 cites W2941817107 @default.

• next