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• W4288033454 abstract "Introduction Neutrophil and eosinophil activation and its relation to disease severity has been understudied in primary care patients with COVID-19. In this study, we investigated whether the neutrophil and eosinophil compartment were affected in primary care patients with COVID-19. Methods COVID-19 patients, aged ≥ 40 years with cardiovascular comorbidity presenting to the general practitioner with substantial symptoms, partaking in the COVIDSat@Home study between January and April 2021, were included. Blood was drawn during and 3 to 6 months after active COVID-19 disease and analyzed by automated flow cytometry, before and after stimulation with a formyl-peptide (fNLF). Mature neutrophil and eosinophil markers at both time points were compared to healthy controls. A questionnaire was conducted on disease symptoms during and 3 to 6 months after COVID-19 disease. Results The blood of 18 COVID-19 patients and 34 healthy controls was analyzed. During active COVID-19 disease, neutrophils showed reduced CD10 ( p = 0.0360), increased CD11b ( p = 0.0002) and decreased CD62L expression ( p &lt; 0.0001) compared to healthy controls. During active COVID-19 disease, fNLF stimulated neutrophils showed decreased CD10 levels ( p &lt; 0.0001). Three to six months after COVID-19 disease, unstimulated neutrophils showed lowered CD62L expression ( p = 0.0003) and stimulated neutrophils had decreased CD10 expression ( p = 0.0483) compared to healthy controls. Both (un)stimulated CD10 levels increased 3 to 6 months after active disease ( p = 0.0120 and p &lt; 0.0001, respectively) compared to during active disease. Eosinophil blood counts were reduced during active COVID-19 disease and increased 3 to 6 months after infection ( p &lt; 0.0001). During active COVID-19, eosinophils showed increased unstimulated CD11b ( p = 0.0139) and decreased (un)stimulated CD62L expression ( p = 0.0036 and p = 0.0156, respectively) compared to healthy controls. Three to six months after COVID-19 disease, (un)stimulated eosinophil CD62L expression was decreased ( p = 0.0148 and p = 0.0063, respectively) and the percentage of CD11b bright cells was increased ( p = 0.0083 and p = 0.0307, respectively) compared to healthy controls. Conclusion Automated flow cytometry analysis reveals specific mature neutrophil and eosinophil activation patterns in primary care patients with COVID-19 disease, during and 3 to 6 months after active disease. This suggests that the neutrophil and eosinophil compartment are long-term affected by COVID-19 in primary care patients. This indicates that these compartments may be involved in the pathogenesis of long COVID." @default.
• W4288033454 created "2022-07-27" @default.
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• W4288033454 date "2022-07-27" @default.
• W4288033454 modified "2023-09-25" @default.
• W4288033454 title "Neutrophil and Eosinophil Responses Remain Abnormal for Several Months in Primary Care Patients With COVID-19 Disease" @default.
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• W4288033454 doi "https://doi.org/10.3389/falgy.2022.942699" @default.
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