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• W4288042534 abstract "The present review describes the clinical relevance of human leukocyte antigen (HLA) donor-specific antibodies (HLA-DSAs) as biomarkers of alloimmunity and summarizes recent improvements in their characterization that provide insights into immune risk assessment, precision diagnosis, and prognostication in transplantation.Recent studies have addressed the clinical utility of HLA-DSAs as biomarkers for immune risk assessment in pretransplant and peritransplant, diagnosis and treatment evaluation of antibody-mediated rejection, immune monitoring posttransplant, and risk stratification.HLA-DSAs have proved to be the most advanced immune biomarkers in solid organ transplantation in terms of analytical validity, clinical validity and clinical utility. Recent studies are integrating multiple HLA-DSA characteristics including antibody specificity, HLA class, quantity, immunoglobulin G subclass, and complement-binding capacity to improve risk assessment peritransplant, diagnosis and treatment evaluation of antibody-mediated rejection, immune monitoring posttransplant, and transplant prognosis evaluation. In addition, integration of HLA-DSAs to clinical, functional and histological transplant parameters has further consolidated the utility of HLA-DSAs as robust biomarkers and allows to build new tools for monitoring, precision diagnosis, and risk stratification for individual patients. However, prospective and randomized-controlled studies addressing the clinical benefit and cost-effectiveness of HLA-DSA-based monitoring and patient management strategies are required to demonstrate that the use of HLA-DSAs as biomarkers can improve current clinical practice and transplant outcomes." @default.
• W4288042534 created "2022-07-27" @default.
• W4288042534 creator A5055171681 @default.
• W4288042534 creator A5091069264 @default.
• W4288042534 date "2022-07-22" @default.
• W4288042534 modified "2023-10-18" @default.
• W4288042534 title "DSA in solid organ transplantation: is it a matter of specificity, amount, or functional characteristics?" @default.
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• W4288042534 doi "https://doi.org/10.1097/mot.0000000000001006" @default.
• W4288042534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35881421" @default.
• W4288042534 hasPublicationYear "2022" @default.
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