Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288045134> ?p ?o ?g. }
- W4288045134 endingPage "110986" @default.
- W4288045134 startingPage "110986" @default.
- W4288045134 abstract "Promoting refractory wound healing remains a major therapeutic challenge. Here, a pain reflex-inspired hydrogel responsive to inflammatory microenvironmental conditions was developed and used to treat chronically infected diabetic wounds. This material was produced by reacting ε-Polylysine, which exhibits antibacterial properties, with oxidized hyaluronic acid to yield a dynamic Schiff base-crosslinked hydrogel capable of undergoing triggered dissociation in response to the lower microenvironmental pH found within refractory wounds. This hydrogel exhibited intrinsic antimicrobial activity owing to the incorporation of ε-Polylysine within the hydrogel network. To imbue the hydrogel with low pH-inducible anti-inflammatory and angiogenic activity, Schiff base bonds were used to capture Deferoxamine (DFO)-loaded amino-functionalized mesoporous silica nanoparticles (MSNs-NH2@DFO) on this hydrogel skeleton. The reflexive behaviors of the hydrogel make it ideally suited to facilitating wound healing in response to excessive local inflammation. The resultant intelligent hydrogel was highly biocompatible and exhibited robust antibacterial, anti-inflammatory, and pro-angiogenic activity in vitro and in vivo, thus effectively promoting the healing of chronically infected diabetic wounds. This novel hydrogel therefore holds great promise as a tool to promote refractory wound healing." @default.
- W4288045134 created "2022-07-27" @default.
- W4288045134 creator A5052085461 @default.
- W4288045134 creator A5064142583 @default.
- W4288045134 creator A5074131487 @default.
- W4288045134 creator A5079594267 @default.
- W4288045134 creator A5080555945 @default.
- W4288045134 creator A5090323759 @default.
- W4288045134 date "2022-09-01" @default.
- W4288045134 modified "2023-10-09" @default.
- W4288045134 title "A pain reflex-inspired hydrogel for refractory wound healing" @default.
- W4288045134 cites W1969949177 @default.
- W4288045134 cites W2419022844 @default.
- W4288045134 cites W2520387279 @default.
- W4288045134 cites W2894451789 @default.
- W4288045134 cites W2914065803 @default.
- W4288045134 cites W2962552845 @default.
- W4288045134 cites W3009930239 @default.
- W4288045134 cites W3023635791 @default.
- W4288045134 cites W3037181905 @default.
- W4288045134 cites W3040735758 @default.
- W4288045134 cites W3042414108 @default.
- W4288045134 cites W3095827815 @default.
- W4288045134 cites W3108471604 @default.
- W4288045134 cites W3122301016 @default.
- W4288045134 cites W3128230390 @default.
- W4288045134 cites W3133005132 @default.
- W4288045134 cites W3133011606 @default.
- W4288045134 cites W3157604216 @default.
- W4288045134 cites W3164079031 @default.
- W4288045134 cites W3164996677 @default.
- W4288045134 cites W3173420867 @default.
- W4288045134 cites W3182336228 @default.
- W4288045134 cites W3192201031 @default.
- W4288045134 cites W3193585681 @default.
- W4288045134 cites W3199890004 @default.
- W4288045134 cites W3203050421 @default.
- W4288045134 cites W3203463952 @default.
- W4288045134 cites W3216835608 @default.
- W4288045134 cites W3217028211 @default.
- W4288045134 cites W4210568695 @default.
- W4288045134 cites W4210817058 @default.
- W4288045134 cites W4211009618 @default.
- W4288045134 cites W4211049269 @default.
- W4288045134 cites W4213231749 @default.
- W4288045134 cites W4220724103 @default.
- W4288045134 cites W4220843661 @default.
- W4288045134 cites W4220990371 @default.
- W4288045134 cites W4223945175 @default.
- W4288045134 cites W4224252150 @default.
- W4288045134 cites W4224324172 @default.
- W4288045134 doi "https://doi.org/10.1016/j.matdes.2022.110986" @default.
- W4288045134 hasPublicationYear "2022" @default.
- W4288045134 type Work @default.
- W4288045134 citedByCount "5" @default.
- W4288045134 countsByYear W42880451342022 @default.
- W4288045134 countsByYear W42880451342023 @default.
- W4288045134 crossrefType "journal-article" @default.
- W4288045134 hasAuthorship W4288045134A5052085461 @default.
- W4288045134 hasAuthorship W4288045134A5064142583 @default.
- W4288045134 hasAuthorship W4288045134A5074131487 @default.
- W4288045134 hasAuthorship W4288045134A5079594267 @default.
- W4288045134 hasAuthorship W4288045134A5080555945 @default.
- W4288045134 hasAuthorship W4288045134A5090323759 @default.
- W4288045134 hasBestOaLocation W42880451341 @default.
- W4288045134 hasConcept C105702510 @default.
- W4288045134 hasConcept C108586683 @default.
- W4288045134 hasConcept C1318750 @default.
- W4288045134 hasConcept C136229726 @default.
- W4288045134 hasConcept C141071460 @default.
- W4288045134 hasConcept C142424586 @default.
- W4288045134 hasConcept C150903083 @default.
- W4288045134 hasConcept C159985019 @default.
- W4288045134 hasConcept C185592680 @default.
- W4288045134 hasConcept C188027245 @default.
- W4288045134 hasConcept C192562407 @default.
- W4288045134 hasConcept C207001950 @default.
- W4288045134 hasConcept C2777529286 @default.
- W4288045134 hasConcept C2780075363 @default.
- W4288045134 hasConcept C2780269544 @default.
- W4288045134 hasConcept C55493867 @default.
- W4288045134 hasConcept C71924100 @default.
- W4288045134 hasConcept C86803240 @default.
- W4288045134 hasConcept C89429830 @default.
- W4288045134 hasConceptScore W4288045134C105702510 @default.
- W4288045134 hasConceptScore W4288045134C108586683 @default.
- W4288045134 hasConceptScore W4288045134C1318750 @default.
- W4288045134 hasConceptScore W4288045134C136229726 @default.
- W4288045134 hasConceptScore W4288045134C141071460 @default.
- W4288045134 hasConceptScore W4288045134C142424586 @default.
- W4288045134 hasConceptScore W4288045134C150903083 @default.
- W4288045134 hasConceptScore W4288045134C159985019 @default.
- W4288045134 hasConceptScore W4288045134C185592680 @default.
- W4288045134 hasConceptScore W4288045134C188027245 @default.
- W4288045134 hasConceptScore W4288045134C192562407 @default.
- W4288045134 hasConceptScore W4288045134C207001950 @default.
- W4288045134 hasConceptScore W4288045134C2777529286 @default.
- W4288045134 hasConceptScore W4288045134C2780075363 @default.