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• W4288045220 endingPage "114749" @default.
• W4288045220 startingPage "114749" @default.
• W4288045220 abstract "This posthoc analysis compared the antidepressant and antisuicidal effects of low-dose ketamine infusion with those of repetitive transcranial magnetic stimulation (rTMS) on treatment-resistant depression (TRD).In the ketamine infusion trial, 48 patients with TRD were randomized to receive a single infusion of 0.5 mg/kg ketamine or normal saline. In the rTMS trial, 105 patients were randomly assigned to intermittent theta-burst stimulation (iTBS), 10-Hz rTMS, or sham stimulation. The 17-item Hamilton Rating Scale for Depression (HDRS) was administered.The antidepressant effect was prominent at Day 7 postinfusion in the ketamine group but steadily accumulated with the treatment duration from Day 7 to 14 in the iTBS and 10-Hz rTMS groups, regardless of the level of treatment resistance (all p < .01). Low-dose ketamine infusion and iTBS exerted superior effects on suicidal symptoms (HDRS item 3) than the other three groups (p < .001). The antidepressant effect of iTBS/10-Hz rTMS may persist for up to 3 months; however, the antidepressant effect of a single low-dose ketamine infusion did not persist over a month.Both low-dose ketamine infusion and rTMS/TBS must be included in TRD treatment but may be applied in different clinical situations." @default.
• W4288045220 created "2022-07-27" @default.
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• W4288045220 date "2022-10-01" @default.
• W4288045220 modified "2023-09-30" @default.
• W4288045220 title "Comparative study of low-dose ketamine infusion and repetitive transcranial magnetic stimulation in treatment-resistant depression: A posthoc pooled analysis of two randomized, double-blind, placebo-controlled studies" @default.
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• W4288045220 doi "https://doi.org/10.1016/j.psychres.2022.114749" @default.
• W4288045220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35940087" @default.
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