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- W4288045282 abstract "Germinal centers (GCs), transient structures within B cell follicles and central to affinity maturation, require the coordinated behavior of T and B cells. IL-21, a pleiotropic T cell-derived cytokine, is key to GC biology through incompletely understood mechanisms. By genetically restricting production and receipt of IL-21 in vivo, we reveal how its independent actions on T and B cells combine to regulate the GC. IL-21 established the magnitude of the GC B cell response by promoting CD4+ T cell expansion and differentiation in a dose-dependent manner and with paracrine activity. Within GC, IL-21 specifically promoted B cell centroblast identity and, when bioavailability was high, plasma cell differentiation. Critically, these actions may occur irrespective of cognate T-B interactions, making IL-21 a general promoter of growth as distinct to a mediator of affinity-driven selection via synaptic delivery. This promiscuous activity of IL-21 explains the consequences of IL-21 deficiency on antibody-based immunity." @default.
- W4288045282 created "2022-07-27" @default.
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- W4288045282 date "2022-08-01" @default.
- W4288045282 modified "2023-10-10" @default.
- W4288045282 title "Interleukin-21, acting beyond the immunological synapse, independently controls T follicular helper and germinal center B cells" @default.
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- W4288045282 doi "https://doi.org/10.1016/j.immuni.2022.06.020" @default.
- W4288045282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35896116" @default.
- W4288045282 hasPublicationYear "2022" @default.