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• W4288045312 endingPage "116947" @default.
• W4288045312 startingPage "116947" @default.
• W4288045312 abstract "MRTX1719 is an inhibitor of the PRMT5/MTA complex and recently entered clinical trials for the treatment of MTAP-deleted cancers. MRTX1719 is a class 3 atropisomeric compound that requires a chiral synthesis or a chiral separation step in its preparation. Here, we report the SAR and medicinal chemistry design strategy, supported by structural insights from X-ray crystallography, to discover a class 1 atropisomeric compound from the same series that does not require a chiral synthesis or a chiral separation step in its preparation." @default.
• W4288045312 created "2022-07-27" @default.
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• W4288045312 date "2022-10-01" @default.
• W4288045312 modified "2023-09-26" @default.
• W4288045312 title "Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors" @default.
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• W4288045312 doi "https://doi.org/10.1016/j.bmc.2022.116947" @default.
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