FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4288045368> ?p ?o ?g. }

• W4288045368 endingPage "127146" @default.
• W4288045368 startingPage "127146" @default.
• W4288045368 abstract "The sensing of environmental conditions such as nutrient availability and the ability to adapt and respond to changing conditions are crucial for the survival of living organisms. Evidence from several organisms have revealed that some metabolic enzymes act as sensors of nutrient status and regulate the expression of sets of genes required for nutrients utilization and condition specific environmental adaptation. Thus metabolic enzymes regulate the signaling pathway by acting as transcriptional regulators and providing required metabolites. The commensal yeast, Candida albicans has recently emerged as a model system for understanding the N-acetylglucosamine (GlcNAc) signaling pathway in eukaryotes. GlcNAc kinase (Hxk1), the first enzyme of the catabolic cascade, has been shown to perform several functions such as regulation of gene expression and regulation of the metabolic status of the cell thereby resulting in a change in cell morphology (yeast-hyphal transition, white-opaque switching), metabolic gene expression, synthesis of metabolic precursors, induction of glycolytic flux rate and biofilm formation. Here, in this review we have discussed various roles of Hxk1that have not been reported in other organisms previously. The enzyme exhibits dynamic changes in subcellular localization consistent with its expanded functions inside the cell. Thus Hxk1 in C. albicans orchestrates several dynamic cellular processes and this signaling system can act as a paradigm to understand the cell fate and metabolic specialization in other eukaryotes too. Still, the molecular cues involved in Hxk1 mediating functions are yet to be unveiled; the relationship between Hxk1 sensing and its signaling effects is also not understood yet." @default.
• W4288045368 created "2022-07-27" @default.
• W4288045368 creator A5027369498 @default.
• W4288045368 creator A5050008242 @default.
• W4288045368 creator A5051434625 @default.
• W4288045368 creator A5056706334 @default.
• W4288045368 date "2022-10-01" @default.
• W4288045368 modified "2023-10-09" @default.
• W4288045368 title "N-acetylglucosamine kinase, Hxk1 is a multifaceted metabolic enzyme in model pathogenic yeast Candida albicans" @default.
• W4288045368 cites W1551721104 @default.
• W4288045368 cites W1599609091 @default.
• W4288045368 cites W1887746592 @default.
• W4288045368 cites W1941117044 @default.
• W4288045368 cites W1974037811 @default.
• W4288045368 cites W1975390013 @default.
• W4288045368 cites W1976281822 @default.
• W4288045368 cites W1978257350 @default.
• W4288045368 cites W1993269776 @default.
• W4288045368 cites W1993563907 @default.
• W4288045368 cites W1999950146 @default.
• W4288045368 cites W2008608436 @default.
• W4288045368 cites W2011405433 @default.
• W4288045368 cites W2011758386 @default.
• W4288045368 cites W2021225422 @default.
• W4288045368 cites W2025505237 @default.
• W4288045368 cites W2028864554 @default.
• W4288045368 cites W2040426981 @default.
• W4288045368 cites W2043177548 @default.
• W4288045368 cites W2046255935 @default.
• W4288045368 cites W2053359084 @default.
• W4288045368 cites W2059214508 @default.
• W4288045368 cites W2060628790 @default.
• W4288045368 cites W2064275134 @default.
• W4288045368 cites W2064795801 @default.
• W4288045368 cites W2070925013 @default.
• W4288045368 cites W2071289410 @default.
• W4288045368 cites W2074972577 @default.
• W4288045368 cites W2076814714 @default.
• W4288045368 cites W2087712604 @default.
• W4288045368 cites W2090632954 @default.
• W4288045368 cites W2109785145 @default.
• W4288045368 cites W2110686257 @default.
• W4288045368 cites W2122481907 @default.
• W4288045368 cites W2123240988 @default.
• W4288045368 cites W2125848302 @default.
• W4288045368 cites W2134676812 @default.
• W4288045368 cites W2137951822 @default.
• W4288045368 cites W2146885685 @default.
• W4288045368 cites W2147044753 @default.
• W4288045368 cites W2147085141 @default.
• W4288045368 cites W2148711203 @default.
• W4288045368 cites W2149297795 @default.
• W4288045368 cites W2156731936 @default.
• W4288045368 cites W2157946772 @default.
• W4288045368 cites W2159385583 @default.
• W4288045368 cites W2164464413 @default.
• W4288045368 cites W2165120664 @default.
• W4288045368 cites W2167391679 @default.
• W4288045368 cites W2170764510 @default.
• W4288045368 cites W2252911663 @default.
• W4288045368 cites W2259890513 @default.
• W4288045368 cites W2345652449 @default.
• W4288045368 cites W2472022668 @default.
• W4288045368 cites W2527959702 @default.
• W4288045368 cites W2551752994 @default.
• W4288045368 cites W2552857490 @default.
• W4288045368 cites W2792847166 @default.
• W4288045368 cites W2896863696 @default.
• W4288045368 cites W2949635797 @default.
• W4288045368 cites W3036821108 @default.
• W4288045368 cites W3047010790 @default.
• W4288045368 cites W3122530486 @default.
• W4288045368 doi "https://doi.org/10.1016/j.micres.2022.127146" @default.
• W4288045368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35940108" @default.
• W4288045368 hasPublicationYear "2022" @default.
• W4288045368 type Work @default.
• W4288045368 citedByCount "0" @default.
• W4288045368 crossrefType "journal-article" @default.
• W4288045368 hasAuthorship W4288045368A5027369498 @default.
• W4288045368 hasAuthorship W4288045368A5050008242 @default.
• W4288045368 hasAuthorship W4288045368A5051434625 @default.
• W4288045368 hasAuthorship W4288045368A5056706334 @default.
• W4288045368 hasBestOaLocation W42880453681 @default.
• W4288045368 hasConcept C101810790 @default.
• W4288045368 hasConcept C104317684 @default.
• W4288045368 hasConcept C165864922 @default.
• W4288045368 hasConcept C181199279 @default.
• W4288045368 hasConcept C184235292 @default.
• W4288045368 hasConcept C191897082 @default.
• W4288045368 hasConcept C192562407 @default.
• W4288045368 hasConcept C192989942 @default.
• W4288045368 hasConcept C19843653 @default.
• W4288045368 hasConcept C2776030549 @default.
• W4288045368 hasConcept C2779222958 @default.
• W4288045368 hasConcept C2780917455 @default.
• W4288045368 hasConcept C2909523446 @default.
• W4288045368 hasConcept C54355233 @default.
• W4288045368 hasConcept C55493867 @default.

• next