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- W4288045474 abstract "Metallic magnesium is a promising platform for H2 cancer therapy, whereas the available Mg particles’ undesirable diameter and shape greatly hinder its therapeutic application. Herein, we first reported the diameter- and shape-controlled synthesis of Mg nanoparticles, including hexagonal nanosheet (∼80–320 nm), nanoflower (∼100–250 nm), and small nanoparticle (mean 65 nm), by a one-pot method. As a proof of concept, pH-sensitive polymer-coated Mg nanoflowers were prepared and applied in NIR (near infrared)-II photoacoustic and bubble-enhanced ultrasound imaging and cancer therapy. It continuously generated H2 in the tumor because the acidic tumor environment triggered the disassembly of the polymeric shell, leading to the reaction of Mg and water. The generated H2 bubbles not only induced transient cavitation and mechanically ruptured lysosomes but also disturbed the cellular energy metabolism and induced high oxidative stress simultaneously, leading to cancer-cell death. Thus, this drug-free therapy method presented superior synergistic tumor inhibition effects." @default.
- W4288045474 created "2022-07-27" @default.
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- W4288045474 date "2022-11-01" @default.
- W4288045474 modified "2023-10-16" @default.
- W4288045474 title "Synthesis of magnesium nanoparticle for NIR-II-photoacoustic-imaging-guided synergistic burst-like and H2 cancer therapy" @default.
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- W4288045474 doi "https://doi.org/10.1016/j.chempr.2022.07.001" @default.
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