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• W4288045753 endingPage "111941" @default.
• W4288045753 startingPage "111941" @default.
• W4288045753 abstract "2-acetylpyridine-4-chloropyridine-2‑carbonyl hydrazone (C13H11ClN4O, HL) and its three water-soluble tetranuclear complexes [Cu4(NO3)2(L)4]·(NO3)2 (1), [Co4(NO3)2(H2O)(C2H5OH)(L)4]·(NO3)2 (2) and [Zn4(NO3)2(H2O)(C2H5OH)(L)4]·(NO3)2 (3) were synthesized and characterized showing that 1–3 were all tetranuclear complexes. The interactions of HL, 1–3 with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) were explored using ultraviolet-visible (UV–Vis) titration, fluorescence spectroscopy, microcalorimetry and molecular docking techniques. The UV–Vis spectroscopy measurements showed that complexes 1–3 could strongly bind to CT-DNA by the intercalation mode, while HL interacted with CT-DNA through groove binding. From the fluorescence spectroscopy results, the interaction between HL, 1–3 and BSA was a static quenching procedure, in which complexes 1–3 had two binding sites near Trp residues of BSA while HL only had one. The microcalorimetric studies revealed that the interactions of HL and 1–3 to CT-DNA/BSA were all endothermic and the duration of each interaction was all less than 30 min. The in silico molecular docking illustrated intermolecular interactions of 1–3 binding with DNA/BSA included hydrogen bond, halogen bond, hydrophobic and electrostatic interactions. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay indicated that complex 1 possessed better cytotoxicity against HeLa, A549, MCF7 and HCT-116 than cisplatin and could be used as an alternative anticancer drug." @default.
• W4288045753 created "2022-07-27" @default.
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• W4288045753 date "2022-11-01" @default.
• W4288045753 modified "2023-10-17" @default.
• W4288045753 title "Three water-soluble acylhydrazone tetranuclear transition metal complexes: Crystal structures, DNA/BSA interactions and cytotoxicity studies" @default.
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• W4288045753 doi "https://doi.org/10.1016/j.jinorgbio.2022.111941" @default.
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