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- W4288045797 abstract "Acetaminophen (APAP) overdose causes liver injury in animals and humans. Although well-studied in animals, limited longitudinal data exist on cytokine release after APAP overdose in patients. The purpose of this study was to quantify concentrations of cytokines in APAP overdose patients to determine if early cytokine or complement measurements can distinguish between surviving and non-surviving patients. Plasma was obtained from healthy controls, APAP overdose patients with no increase in liver transaminases, and surviving and non-surviving APAP overdose patients with severe liver injury. Interleukin-10 (IL-10), and CC chemokine ligand-2 (CCL2, MCP-1) were substantially elevated in surviving and non-surviving patients, whereas IL-6 and CXC chemokine ligand-8 (CXCL8, IL-8) had early elevations in a subset of patients only with liver injury. Day 1 IL-10 and IL-6 levels, and Day 2 CCL2, levels correlated positively with survival. There was no significant increase in IL-1α, IL-1β or TNF-α in any patient during the first week after APAP. Monitoring cytokines such as CCL2 may be a good indicator of patient prognosis; furthermore, these data indicate the inflammatory response after APAP overdose in patients is not mediated by a second phase of inflammation driven by the inflammasome." @default.
- W4288045797 created "2022-07-27" @default.
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- W4288045797 date "2022-08-01" @default.
- W4288045797 modified "2023-10-16" @default.
- W4288045797 title "Generation of pro-and anti-inflammatory mediators after acetaminophen overdose in surviving and non-surviving patients" @default.
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- W4288045797 cites W1969981758 @default.
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- W4288045797 cites W1983576933 @default.
- W4288045797 cites W1985041654 @default.
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- W4288045797 cites W2014325254 @default.
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- W4288045797 doi "https://doi.org/10.1016/j.toxlet.2022.07.813" @default.
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