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- W4288045997 endingPage "114463" @default.
- W4288045997 startingPage "114463" @default.
- W4288045997 abstract "This review aims to provide a systemic analysis of the in vivo, as well as subcellular, fate of polymeric micelles (PMs), starting from the entry of PMs into the body. Few PMs are able to cross the biological barriers intact and reach the circulation. In the blood, PMs demonstrate fairly good stability mainly owing to formation of protein corona despite controversial results reported by different groups. Although the exterior hydrophilic shells render PMs “long-circulating”, the biodistribution of PMs into the mononuclear phagocyte systems (MPS) is dominant as compared with non-MPS organs and tissues. Evidence emerges to support that the copolymer poly(ethylene glycol)-poly(lactic acid) (PEG-PLA) is first broken down into pieces of PEG and PLA and then remnants to be eliminated from the body finally. At the cellular level, PMs tend to be internalized via endocytosis due to their particulate nature and disassembled and degraded within the cell. Recent findings on the effect of particle size, surface characteristics and shape are also reviewed. It is envisaged that unraveling the in vivo and subcellular fate sheds light on the performing mechanisms and gears up the clinical translation of PMs." @default.
- W4288045997 created "2022-07-27" @default.
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- W4288045997 creator A5088215418 @default.
- W4288045997 date "2022-09-01" @default.
- W4288045997 modified "2023-10-18" @default.
- W4288045997 title "The in vivo fate of polymeric micelles" @default.
- W4288045997 cites W1171856860 @default.
- W4288045997 cites W1192952131 @default.
- W4288045997 cites W1414886268 @default.
- W4288045997 cites W1543335328 @default.
- W4288045997 cites W1598629067 @default.
- W4288045997 cites W1679811816 @default.
- W4288045997 cites W1683893159 @default.
- W4288045997 cites W1770563882 @default.
- W4288045997 cites W1789103649 @default.
- W4288045997 cites W1792931483 @default.
- W4288045997 cites W1844367325 @default.
- W4288045997 cites W1904873550 @default.
- W4288045997 cites W1918322381 @default.
- W4288045997 cites W1927566132 @default.
- W4288045997 cites W1944574444 @default.
- W4288045997 cites W1963675633 @default.
- W4288045997 cites W1964185052 @default.
- W4288045997 cites W1964947406 @default.
- W4288045997 cites W1965568849 @default.
- W4288045997 cites W1965593909 @default.
- W4288045997 cites W1966662116 @default.
- W4288045997 cites W1966961208 @default.
- W4288045997 cites W1967104248 @default.
- W4288045997 cites W1967341162 @default.
- W4288045997 cites W1968061953 @default.
- W4288045997 cites W1968128233 @default.
- W4288045997 cites W1969446217 @default.
- W4288045997 cites W1971464541 @default.
- W4288045997 cites W1971540622 @default.
- W4288045997 cites W1971925857 @default.
- W4288045997 cites W1972180606 @default.
- W4288045997 cites W1975158551 @default.
- W4288045997 cites W1975857280 @default.
- W4288045997 cites W1976194752 @default.
- W4288045997 cites W1979046460 @default.
- W4288045997 cites W1982393679 @default.
- W4288045997 cites W1983232412 @default.
- W4288045997 cites W1983508787 @default.
- W4288045997 cites W1984319911 @default.
- W4288045997 cites W1984677400 @default.
- W4288045997 cites W1985006200 @default.
- W4288045997 cites W1985037778 @default.
- W4288045997 cites W1986246906 @default.
- W4288045997 cites W1986339830 @default.
- W4288045997 cites W1990772328 @default.
- W4288045997 cites W1990869510 @default.
- W4288045997 cites W1992588670 @default.
- W4288045997 cites W1995995697 @default.
- W4288045997 cites W1996139192 @default.
- W4288045997 cites W1997236997 @default.
- W4288045997 cites W1998048783 @default.
- W4288045997 cites W1999117380 @default.
- W4288045997 cites W1999877512 @default.
- W4288045997 cites W2000082568 @default.
- W4288045997 cites W2000257842 @default.
- W4288045997 cites W2001257757 @default.
- W4288045997 cites W2001983171 @default.
- W4288045997 cites W2002182083 @default.
- W4288045997 cites W2002516695 @default.
- W4288045997 cites W2003103971 @default.
- W4288045997 cites W2003110090 @default.
- W4288045997 cites W2007440635 @default.
- W4288045997 cites W2010262551 @default.
- W4288045997 cites W2012685690 @default.
- W4288045997 cites W2012716219 @default.
- W4288045997 cites W2015150662 @default.
- W4288045997 cites W2015346163 @default.
- W4288045997 cites W2016382049 @default.
- W4288045997 cites W2016721378 @default.
- W4288045997 cites W2020150601 @default.
- W4288045997 cites W2020797655 @default.
- W4288045997 cites W2020994460 @default.
- W4288045997 cites W2022646304 @default.
- W4288045997 cites W2029192085 @default.
- W4288045997 cites W2029208937 @default.
- W4288045997 cites W2029847924 @default.
- W4288045997 cites W2030680926 @default.
- W4288045997 cites W2031381256 @default.
- W4288045997 cites W2031406458 @default.
- W4288045997 cites W2031754029 @default.
- W4288045997 cites W2032534436 @default.
- W4288045997 cites W2032642047 @default.
- W4288045997 cites W2032860131 @default.
- W4288045997 cites W2033281188 @default.
- W4288045997 cites W2033396701 @default.
- W4288045997 cites W2033486390 @default.
- W4288045997 cites W2035536790 @default.
- W4288045997 cites W2036459378 @default.